Development of the Female Reproductive Tract and Associated Anomalies

Arbuckle, Janeen L.; Hoover, Kimberly

doi:10.1007/s40746-016-0064-6

Cited by 2 publications

(2 citation statements)

References 51 publications

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“…However, up to 10% of women suffer from congenital abnormalities of the vagina, uterus, or oviducts [ 1 – 3 ], which has devastating consequences for their reproductive and psychological health [ 4 ]. The most common congenital obstructive anomalies of the reproductive tract are imperforate hymen (observed in 1:1000 females), followed by a transverse vaginal septum and vaginal atresia [ 5 , 6 ]. Despite occurring at high frequencies, the etiologies of most vaginal abnormalities are unknown [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

High incidence of imperforate vagina in ADGRA3-deficient mice

Kvam,

Nybo,

Torz

et al. 2024

BMC Biol

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Background Ten percent of the female population suffers from congenital abnormalities of the vagina, uterus, or oviducts, with severe consequences for reproductive and psychological health. Yet, the underlying causes of most of these malformations remain largely unknown. ADGRA3 (GPR125) is involved in WNT signaling and planar cell polarity, mechanisms vital to female reproductive tract development. Although ADGRA3 is a well-established spermatogonial stem cell marker, its role within the female urogenital system remains unclear. Results In this study, we found Adgra3 to be expressed throughout the murine female urogenital system, with higher expression pre-puberty than after sexual maturation. We generated a global Adgra3−/− mouse line and observed imperforate vagina in 44% of Adgra3−/− females, resulting in distension of the reproductive tract and infertility. Ovarian morphology, plasma estradiol, ovarian Cyp19a1, and vaginal estrogen receptor α (Esr1) expression were unaffected. However, compared to controls, a significantly lower bone mineral density was found in Adgra3−/− mice. Whereas vaginal opening in mice is an estrogen-dependent process, 17β-estradiol treatment failed to induce vaginal canalization in Adgra3−/− mice. Furthermore, a marked reduction in vaginal and ovarian progesterone receptor expression was observed concomitant with an upregulation of apoptotic regulators Bcl2, Bid, and Bmf in adult Adgra3−/− females with a closed vagina. Conclusions Our collective results shed new insights into the complex mechanisms by which the adhesion receptor ADGRA3 regulates distal vaginal tissue remodeling during vaginal canalization via altered sex hormone responsiveness and balance in apoptotic regulators. This highlights the potential of ADGRA3 as a target in diagnostic screening and/or therapy for obstructive vaginal malformations in humans.

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Section: Introductionmentioning

confidence: 99%

High incidence of imperforate vagina in ADGRA3-deficient mice

Kvam,

Nybo,

Torz

et al. 2024

BMC Biol

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“…[6][7][8] They have different impacts on human reproductive function differs according to the type of the anomaly and the extent of anatomical distortion, affected individuals may have either entirely normal fertility and sexual life, or it can lead to serious sexual and fertility problems like amenorrhea, severe dysmenorrhea, miscarriage, preterm delivery, and most importantly infertility. 1,[10][11][12] Although the exact prevalence of female genital tract anomalies is difficult to be known, as many cases are asymptomatic and not detected. 13 It is estimated that the prevalence of such anomaly in the general population to be around 4-7%.…”

Section: Introductionmentioning

confidence: 99%

Congenital anomalies of reproductive system among infertile women attending Dr. Khawer Center for Infertility and IVF in Maternity Teaching Hospital in Erbil city: A retrospective study

Taha¹,

Amin

2019

Zanco J. Med. Sci.

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2010 to the 1 st January 2015 were collected from patient files, such as age, sex, residence, type of infertility, type of anomaly, duration of infertility, Karyotype, Intervention, Success rate of intervention, cycle, parity, history of abortions, history of preterm deliveries, and history of ectopic pregnancy. Results: The prevalence of congenital reproductive system anomaly was 4.1% among infertile women. The sub-septate uterus was the most common type (23.24%) anomalies. No significant association was found between the types of the anomaly and the type of infertility. The genetic factor was found to has a significant role in developing such a condition. Success rate after management significantly raised to 61.1% with sub-septate uterus (91.3%) bicornuate/ partial (85.7%), and septate/ complete (72.2%). Conclusion:One of the causative factors of female infertility is congenital anomaly. Most types have a good prognosis in achieving pregnancy after proper management.

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Development of the Female Reproductive Tract and Associated Anomalies

Cited by 2 publications

References 51 publications

High incidence of imperforate vagina in ADGRA3-deficient mice

High incidence of imperforate vagina in ADGRA3-deficient mice

Congenital anomalies of reproductive system among infertile women attending Dr. Khawer Center for Infertility and IVF in Maternity Teaching Hospital in Erbil city: A retrospective study

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