High incidence of imperforate vagina in ADGRA3-deficient mice
Jone Marita Kvam,
Maja Lind Nybo,
Lola Torz
et al.
Abstract:Background
Ten percent of the female population suffers from congenital abnormalities of the vagina, uterus, or oviducts, with severe consequences for reproductive and psychological health. Yet, the underlying causes of most of these malformations remain largely unknown. ADGRA3 (GPR125) is involved in WNT signaling and planar cell polarity, mechanisms vital to female reproductive tract development. Although ADGRA3 is a well-established spermatogonial stem cell marker, its role within the female… Show more
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