Development of the European Organisation for Research and Treatment of Cancer quality of life questionnaire module for older people with cancer: The EORTC QLQ-ELD15

Johnson, Colin A.; Fitzsimmons, Deborah; Gilbert, Jeffrey M.; Arrarras, Juan-Ignacio; Hammerlid, Eva; Brédart, Anne; Özmen, Mahir; Dilektaşlı, Evren; Coolbrandt, Anne; Kenis, Cindy; Young, Teresa; Chow, Edward; Venkitaraman, Ramachandran; Howse, Frances; George, Steve; O'Connor, Steve; Yadegarfar, Ghasem

doi:10.1016/j.ejca.2010.04.014

Cited by 68 publications

(68 citation statements)

References 30 publications

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“…Age differences in unmet needs and the high proportion of 'not applicable' responses imply that older patients have a different needs profile to younger patients. Age-specific instruments have been suggested in quality of life research [13,19], both to capture additional information about older patients and to overcome identified measurement issues. Some quality of life instruments, for example, have demonstrated a heavy response burden and increased requirement for interview administration with advancing age [8].…”

Section: Discussionmentioning

confidence: 99%

Unmet supportive care needs in colorectal cancer: differences by age

Jorgensen

Young

Harrison

et al. 2011

Support Care Cancer

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Section: Discussionmentioning

confidence: 99%

Unmet supportive care needs in colorectal cancer: differences by age

Jorgensen

Young

Harrison

et al. 2011

Support Care Cancer

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“…Most authors agree that cancer pain management is best provided in close collaboration with a palliative care service (team) [2]. In a recent systematic review on cancer pain, Portenoy et al [60] found that in (breast) cancer patients pain is rarely an isolated problem. Patients frequently suffer from many different symptoms and other worries.…”

Section: Non-pharmacologic Interventionsmentioning

confidence: 99%

Cancer Pain Management and Bone Metastases: An Update for the Clinician

Schneider

Voltz²,

Gaertner³

2012

Breast Care

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Breast cancer patients with bone metastases often suffer from cancer pain. In general, cancer pain treatment is far from being optimal for many patients. To date, morphine remains the gold standard as first-line therapy, but other pure µ agonists such as hydromorphone, fentanyl, or oxycodone can be considered. Transdermal opioids are an important option if the oral route is impossible. Due to its complex pharmacology, methadone should be restricted to patients with difficult pain syndromes. The availability of a fixed combination of oxycodone and naloxone is a promising development for the reduction of opioid induced constipation. Especially bone metastases often result in breakthrough pain episodes. Thus, the provision of an on-demand opioid (e.g., immediate-release morphine or rapid-onset fentanyl) in addition to the baseline (regular) opioid therapy (e.g., sustained-release morphine tablets) is mandatory. Recently, rapid onset fentanyls (buccal or nasal) have been strongly recommended for breakthrough cancer pain due to their fast onset and their shorter duration of action. If available, metamizole is an alternative non-steroid-anti-inflammatory-drug. The indication for bisphosphonates should always be checked early in the disease. In advanced cancer stages, glucocorticoids are an important treatment option. If bone metastases lead to neuropathic pain, coanalgetics (e.g., pregabalin) should be initiated. In localized bone pain, radiotherapy is the gold standard for pain reduction in addition to pharmacologic pain management. In diffuse bone pain radionuclids (such as samarium) can be beneficial. Invasive measures (e.g., neuroaxial blockage) are rarely necessary but are an important option if patients with cancer pain syndromes are refractory to pharmacologic management and radiotherapy as described above. Clinical guidelines agree that cancer pain management in incurable cancer is best provided as part of a multiprofessional palliative care approach and all other domains of suffering (psychosocial, spiritual, and existential) need to be carefully addressed (‘total pain’).

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“…Patient sample sizes were determined based on sample sizes in recently published studies, identified by a literature review, which reported the development of patient questionnaires across a diverse range of therapeutic areas: pediatrics, dermatology, cardiovascular, oncology, and allergy [27][28][29][30][31][32][33] . Our sample sizes were consistent with those in the reported literature.…”

Section: Development Phase Of Bone'smentioning

confidence: 99%