Development of the coronary arteries in rat embryos

Dbalý, J; Ošťádal, B; Rychter, Z

doi:10.1159/000143186

Cited by 40 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…15 This simplistic developmental scheme might seem to facilitate our understanding of all known coronary artery abnormalities, including an aberrant origin of the left coronary artery from the pulmonary trunk (a condition known as Bland-White-Garland syndrome). However, we (in this report) and others 16,17 have failed to find any endothelial buds originating from the pulmonary sinuses. We believe the aberrant origin of the coronary artery from the pulmonary trunk may be attributable to an abnormal development of the endothelial strands penetrating the pulmonary trunk from the PR rather than to the persistence of a vessel arising from the pulmonary trunk.…”

Section: Relation Between Multiple Endothelial Strands and Human Corocontrasting

confidence: 63%

“…[12][13][14][15] Although this is a frequent assumption in the literature, sprouting of coronary arteries from the aorta has never been documented by micrographs showing an endothelial evagination. 5 In fact, Dbaly et al 16 failed to find a blind aortic evagination in rat embryos, whereas Bogers and colleagues 17,18 found no coronary orifice without a connection to a proximal coronary artery. On the basis of such observations, it has therefore been concluded that the proximal segment of the coronary arteries develops by endothelial ingrowth from the PR rather than by endothelial outgrowth from the aorta.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Development of Proximal Coronary Arteries in Quail Embryonic Heart

Ando

Nakajima

Yamagishi

et al. 2004

Circulation Research

View full text Add to dashboard Cite

Abstract-Studies have shown that the proximal coronary artery (PCA) develops via endothelial ingrowth from the peritruncal ring (PR) of the coronary vasculature. However, the details of PCA formation remain unclear. We examined the development of PCAs in quail embryonic hearts from 5 to 9 days of incubation (embryonic day [ED]) using double-immunostaining for QH1 (quail endothelial marker) and smooth muscle ␣-actin. At 6 to 7 ED, several QH1-positive endothelial strands from the PR penetrated the facing sinuses, and in some embryos, several endothelial strands penetrated the posterior (noncoronary) sinus. At 7 to 8 ED, the endothelial strands penetrating the facing sinuses seemed to fuse, forming a proximal coronary stem that was demarcated from the aortic wall by the nascent smooth muscle layer of the coronary artery. By 9 ED, two coronary stems were completely formed, and the endothelial strands previously penetrating the noncoronary sinus had disappeared. Confocal microscopy at 6 ED revealed discontinuous QH1-positive endothelial progenitors in the aortic wall at sites where the endothelial strands would later develop.Observations demonstrate that during the formation of the PCA, endothelial strands from the PR penetrate the facing sinuses and then fuse, whereas those strands penetrating the noncoronary sinus disappear. Thereafter, the coronary artery tunica media demarcates the definitive PCA from the aortic media. Key Words: coronary artery Ⅲ development Ⅲ quail embryo Ⅲ QH1 D uring early heart development, a coronary circulation is absent, because the cardiomyocytes are in direct contact with the endocardium. 1 After the formation of the d-loop heart (stage 14 to 15 in chick embryo, 2 2.5 embryonic day [ED]), the proepicardial organ develops from the dorsal mesocardium of the sinus venosus, migrates onto the surface of the cardiac tube, and gives rise to the primitive epicardium. 3,4 After the formation of the epicardial covering of the heart, vascular buds or blood island-like structures, which arise in the epicardium, form in various species, including birds. 5,6 In chick embryo, endothelially lined vascular anlagen appear in the epicardium at approximately stage 21 (3.5 ED). 4 Coronary vascularization begins to occur at stage 32 (7.5 ED), first as venous sinusoids in connection with trabecular channels and second as coronary arterial vessels anastomosing with the venous sinusoids. 7 Then a closed coronary system is completed by stage 41 (15 ED). 7 Recent experiments with chick-quail chimeras and retroviral tracers have shown that not only coronary vessel endothelial cells but also smooth muscle cells originate from the epicardium. 8 -10 Retroviral-tracer experiments have also made clear that the cells making up the coronary vessels originate from discontinuous colonies, suggesting that coronary vessels are established by vasculogenesis rather than by angiogenesis. 8 Several investigators have examined the origin of the proximal coronary artery stems and coronary orifices. A process often assumed to be...

show abstract

Section: Relation Between Multiple Endothelial Strands and Human Corocontrasting

confidence: 63%

mentioning

confidence: 99%

Development of Proximal Coronary Arteries in Quail Embryonic Heart

Ando

Nakajima

Yamagishi

et al. 2004

Circulation Research

View full text Add to dashboard Cite

show abstract

“…The veins of the outflow tract are short. By the end of fetal life, the pattern of major vessel distribution reaches a final shape and position equivalent to those seen in the adult rat heart (Jons and Olson, 1954;Dbalý et al, 1968;Beighley et al, 1997). The course and branching system of the major vessels, however, appear to depend on the rat strain.…”

Section: Discussionmentioning

confidence: 94%

Embryonic development of coronary vasculature in rats: Corrosion casting studies

2003

View full text Add to dashboard Cite

The aim of this study was to analyze the development of coronary vessels at different stages of embryonic life in rats using corrosion casts and scanning electron microscopy (SEM). We studied morphologic details of vessel maturation, expansion, and pattern formation from the stage of development when the coronary system forms patent connections with the aorta and the right atrium (embryonic day 16 (ED16)) to full-term fetus (ED21). The internal surface morphologies of the arterial and venous vessel walls were different and were dependent on the distance from the orifice and the capillary system. They also depended on the maturation state of a given vessel. In various branches of the coronary system we demonstrated round, fusiform or polygonal, endothelial cell imprints. The capillary network was dense, however, at the early stages of development, it formed a thin layer over the myocardium. By ED21 capillaries assumed an orientation parallel to the long axes of the cardiac myocytes. During all stages of development, different forms of angiogenesis by intussusceptive growth were observed. Splitting of the vessel wall occurred in two or three points along the vessel, forming two-or three-link chains. Certain areas of vessels resembled doughnuts, from which several sister vessels originated. The coronary arteries were situated deep within the myocardial wall. The major coronary veins were mostly located on the surface of the capillary plexuses of the myocardial wall. In conclusion, this method of vessel casting enables the detection of angiogenesis by intussusceptive growth, and the visualization of a capillary's position to the myocardial wall, thickness of the capillary plexuses, and the internal surface morphology of major vessels. Anat Rec Part A 270A: 109 -116, 2003.

show abstract

“…The thickness of the compact part of the myocardial wall showed little change during the period when the plexus appeared, and the overall distance from the chamber cavity to the epicardium actually decreased. All stage 14 and 15 embryos with capillaries, 15 …”

Section: Resultsmentioning

confidence: 99%

Development of the coronary arteries in the embryonic human heart.

1988

View full text Add to dashboard Cite

It is not known why the coronary arteries almost always originate only from the right and left aortic sinuses of Valsalva, since the structure and conditions appear to be the same for all six sinuses of the embryonic great arteries. We sought a possible mechanical explanation for the phenomenon by studying the development of Materials and methodsThe serial histologic sections of 351 normal human embryos of Carnegie stages 9 through 23 in the Carnegie Embryological Collection at the University of California, Davis, were examined through the courtesy of Dr. Ronan O'Rahilly, Director of the Carnegie Embryological Laboratories. Most of the embryos in this collection have been catalogued. 17-22 Embryos were examined histologically and the presence or absence of a number of anatomic features, especially of the cardiovascular system, was recorded. To prepare three-dimensional reconstructions, the histologic sections of selected embryos were photomicrographed on Kodak Technical Pan 2415 film with use of a 35 mm camera mounted on a Leitz microscope with either a 1.0 X or 2.5 x objective lens. The number of photomicrographs for each embryo varied from every section to every fifth section in the sequence, depending on section thickness, size of the embryo, and rapidity of change in the anatomic relationships between CIRCULATION by guest on May 12, 2018 http://circ.ahajournals.org/ Downloaded from

show abstract

Development of the coronary arteries in rat embryos

Cited by 40 publications

References 0 publications

Development of Proximal Coronary Arteries in Quail Embryonic Heart

Development of Proximal Coronary Arteries in Quail Embryonic Heart

Embryonic development of coronary vasculature in rats: Corrosion casting studies

Development of the coronary arteries in the embryonic human heart.

Contact Info

Product

Resources

About