Development of surface modified nanoparticles of curcumin for topical treatment of diabetic retinopathy: In vitro, ex vivo and in vivo investigation

Potential therapeutic effects of naringin loaded PLGA nanoparticles for the management of Alzheimer's disease: In vitro, ex vivo and in vivo investigation

“…The particle size and PDI (polydispersity index) of each batch was estimated (Horiba logical nano Partica nano-molecule analyzer SZ-100V2).The dispersion was then passed through a 0.45 μm membrane filter. All filtrates were cold centrifuged at 4 °C, 15,000 rpm for 20 min, and the supernatant was used to calculate percent entrapment efficiency (%EE) [ 9 ].…”

“…Optimized nanoparticles were subjected for determination of zeta potential. Nanoparticles were dispersed in distilled water and tested by surface chargesby utilizing Horiba logical nano Partical nano-molecule analyzer SZ-100V2 [ 9 ].…”

“…To replace the withdrawn samples, a new release medium was added. The overall percent cumulative drug release was determined [ 9 , 13 ].…”

“…Spray-dried drug-loaded nanoparticles were subjected to analysis of shape and surface morphology by using scanning electron microscopy (Zeiss) operatedat an accelerated voltage of 20 kV [ 9 ].…”

“…X-ray diffractogram of the drug and drug-loaded nanoparticles was recorded by using a diffractometer(Bruker Bragg2D). All measurements were taken using at 2θangle scale that went from 0 to 50°.A Cu-Ka line has been used as a source of radiation for the determination of diffractogram [ 9 ].…”