Development of Supported Liquid-Phase Microextraction Probes for In Vivo PK Studies

Abstract

The proposed method was successfully applied to monitor the PK profile of oxybutynin. The drug followed a two-compartment model, with a volume of distribution of 14 l/kg and a half-life of 76 min.

Polydopamine coated hypodermic needles as a microextraction device for the determination of tricyclic antidepressants in oral fluid by direct infusion MS/MS

“…HNs have been mainly used to house the extraction probes for in vivo approaches in the sample preparation context. [31][32][33] In this article, the use of HNs as the actual microextraction device is presented. The surface of a stainless-steel needle was coated with polydopamine (PDA), a very promising sorbent.…”