Discovery Bioanalysis and In Vivo Pharmacology as an Integrated Process: A Case Study in Oncology Drug Discovery

Abstract

This process provided unique opportunities for the characterization of drug properties, selection and assessment of compounds in animal models and to support and expedite proof-of-concept studies in oncology.

HRMS in DMPK

“…Interest in using high-resolution MS (HRMS) continues to expand in the bioanalysis arena as well as other pharmaceutical applications [2][3][4][5][6][7][8][9]. In addition to DMPK applications based on small molecules [10][11][12], HRMS is also being utilized for large molecules including proteins and peptide therapeutics [13][14][15].…”