Development of suction force during early diastole from the left atrium to the left ventricle in infants, children, and adolescents

Takahashi, Ken; Nii, Masaki; Takigiku, Kiyohiro; Toyono, Manatomo; Iwashima, Satoru; Inoue, Nao; Tanaka, Noboru; Matsui, Kotoko; Shigemitsu, Sachie; Yamada, Mariko; Kobayashi, Maki; Yazaki, Kana; Shimizu, Toshiaki

doi:10.1007/s00380-018-1239-9

Cited by 19 publications

(21 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, the diastolic dysfunction described above in adults is seen in the fetus manifesting as abnormal diastolic waveforms seen by Doppler velocimetry. An early diastolic suctional force in the heart has been demonstrated following delivery of the infant [111][112][113][114][115].…”

Section: Upon Sharing His Findings With Homeopathic Physicianmentioning

confidence: 99%

Ozone Preconditioning: Waking up the dragon

Thorp¹,

Thorp²

2021

The GMS

View full text Add to dashboard Cite

It is said that no discovery is complete until its implications have been fully realized. The identification of a previously unrecognized phenomenon says little of its potential effects. What appears as a stroke of good luck can culminate in disaster; misfortune may harbor unimagined potential. Discovery is a double-edged sword that manifests only over time. Nowhere is this aphorism more applicable than in contemporary medical science.

show abstract

Section: Upon Sharing His Findings With Homeopathic Physicianmentioning

confidence: 99%

Ozone Preconditioning: Waking up the dragon

Thorp¹,

Thorp²

2021

The GMS

View full text Add to dashboard Cite

show abstract

“…IVPD is obtained from color M-mode echocardiographic (CMME) images using Euler's equation [10]. The intraventricular pressure gradient (IVPG) can be calculated by dividing the IVPD by the length of the left ventricle (LV); consequently, unlike the IVPD, IVPG is not affected by the size of the heart [11][12][13]. Generally, the length of the LV, from the mitral valve to the apex, is divided into basal, mid, and apical parts, and each has its corresponding IVPG index.…”

Section: Introductionmentioning

confidence: 99%

The Utility of Intraventricular Pressure Gradient for Early Detection of Chemotherapy-Induced Subclinical Cardiac Dysfunction in Dogs

Matsuura

Shiraishi

Mandour

et al. 2021

Animals

Self Cite

View full text Add to dashboard Cite

Early detection of doxorubicin (DXR)-induced cardiomyopathy (DXR-ICM) is crucial to improve cancer patient outcomes and survival. In recent years, the intraventricular pressure gradient (IVPG) has been a breakthrough as a sensitive index to assess cardiac function. This study aimed to evaluate the usefulness of IVPG for the early detection of chemotherapy-related cardiac dysfunction. For this purpose, six dogs underwent conventional, speckle tracking, and color M-mode echocardiography concomitantly with pressure-and-volume analysis by conductance catheter. The cardiac function measurements were assessed before DXR administration (baseline, Pre), at the end of treatment protocol (Post), and at 1.5 years follow-up (Post2). The result showed a significant reduction in the left ventricular end-systolic pressure-volume (Emax: 4.4 ± 0.7, 6.1 ± 1.6 vs. 8.4 ± 0.8 mmHg/mL), total-IVPG (0.59 ± 0.12, 0.62 ± 0.15 vs. 0.86 ± 0.12 mmHg), and mid-IVPG (0.28 ± 0.12, 0.31 ± 0.11 vs. 0.48 ± 0.08 mmHg), respectively in Post2 and Post compared with the baseline (p < 0.05). Mid-to-apical IVPG was also reduced in Post2 compared with the baseline (0.29 ± 0.13 vs. 0.51 ± 0.11). Meanwhile, the fraction shortening, ejection fraction, and longitudinal strain revealed no change between groups. Total and mid-IVPG were significantly correlated with Emax (R = 0.49; p < 0.05, both) but only mid-IVPG was a predictor for Emax (R2 = 0.238, p = 0.040). In conclusion, this study revealed that impairment of contractility was the initial changes observed with DXR-ICM in dogs and only IVPG could noninvasively detect subclinical alterations in cardiac function. Color M-mode echocardiography-derived IVPG could be a potential marker for the early detection of doxorubicin cardiomyopathy.

show abstract

“…Because the echocardiographic indices change as human grows. The changes in cardiac function during the growth period can be explained by the functional change due to the developing myocardial function rather than the change in the ventricular size 10 . Therefore, the study design using growing human is not suitable for the evaluating the contribution of chamber size to the cardiac function.…”

mentioning

confidence: 99%

Changes in left ventricular blood flow during diastole due to differences in chamber size in healthy dogs

Matsuura

Sato

Shimada

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

Vorticity is a novel index that reflects diastolic function of left ventricle. The size of the ventricle can influence the ventricular diastolic blood flow. We evaluated effect of ventricular size on diastolic function and diastolic intracardiac blood flow using a particular species of dogs, which has a wide range of body size. Vector flow mapping was used for evaluation of intracardiac blood flow, and intraventricular pressure gradient (IVPG) was used for evaluation of diastolic function. 58 dogs weighing 1.3-42.3 kg were included in this study. Vorticity was found to be inversely proportional to the length of the ventricular chamber. Intraventricular pressure difference was positively correlated with the length of the left ventricle, whereas IVPG was not. This study showed that the vorticity is influenced by the size of the left ventricle independently of other factors. To evaluate the hemodynamic state of each individual appropriately by using vorticity and IVPD, ventricular size should be taken into account especially in the field of veterinary medicine and human pediatric and adolescent cardiology.www.nature.com/scientificreports www.nature.com/scientificreports/ vorticity and EL. A stepwise method was used for selection of the variables, choosing the variables which minimized Akaike's information criterion. ResultsStudy population. The number of cases was 58. The mean weight was 8.65 (1.3-42.3, SD 6.93) kg. The length of the left ventricle was 34.0 (21.9-49.0, SD 7.3) mm on average. The mean heart rate was 117.6 (66.0-Characteristics of the canine heart with various size. The mean value of the short axis inner diameter of the left ventricle (LVIDd) was SD 7.36) mm. The sphericity index (SI) of the left ventricle was 0.75 (0.51-1.0, SD 0.12). The relationship between short and long axis diameter was shown in Fig. 1. LVL was linearly correlated with LVIDd (R = 0.78, p < 0.01). Statistical correlation was not found between LVL and SI.Conventional indexes of diastolic property (E vel, e′, E/A, E/e′) were not statistically correlated with LVL.Scientific RepoRtS | (2020) 10:1106 | https://doi.

show abstract

Development of suction force during early diastole from the left atrium to the left ventricle in infants, children, and adolescents

Cited by 19 publications

References 28 publications

Ozone Preconditioning: Waking up the dragon

Ozone Preconditioning: Waking up the dragon

The Utility of Intraventricular Pressure Gradient for Early Detection of Chemotherapy-Induced Subclinical Cardiac Dysfunction in Dogs

Changes in left ventricular blood flow during diastole due to differences in chamber size in healthy dogs

Contact Info

Product

Resources

About