Development of structurally diverse antitubercular molecules with pyridazine ring

Abstract

There has been considerable interest in the development of new molecule with antibacterial activities particularly against tuberculosis because mycobacterium species have developed resistance against currently used drugs, their toxic effect, and longer duration of therapy. The pyridazine derivatives are an important class of compound for new drugs research and development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their antitubercular activity. These observations have been guiding in the development of new molecules that possess potent antitubercular activity with minimum side effects or effective against multidrug-resistant, extensively drug-resistant mycobacterium strains, and also in patient co-infected with HIV/AIDS.

Synthesis of Some Novel Norbornene‐Fused Pyridazines as Potent Inhibitors of Carbonic Anhydrase and Acetylcholinesterase

“…) . Several compounds derived from pyridazines scaffold have been reported to possess a wide spectrum of biological activity such as the antidepressant, dopaminergic drug, monoamine oxidase inhibitor, anticonvulsant, GABA antagonist, muscarinic M1 partial agonist, and acetylcholinesterase (AChE) inhibitor . The chemistry of pyridazines is also dominantly useful as a pioneer for the preparation of other heterocycles, pi‐conjugated organic materials, and self‐assembled supramolecular architectures .…”

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“…Examples are far too numerous to give more than a flavor of the reported chemistry, however it should be noted that pyridazine based systems are less common in the literature than those based on pyridine or the other diazines. Various pyridazine-based heterocyclic scaffolds have been utilized in recent medicinal chemistry programs against a range of biological targets and physiological effects [1][2][3][4][5].…”

How different is pyrimidine as a core component of DNA base from its diazine isomers: A DFT study?

“…Due to its application as a pharmacophore unit, PyD are usually industrial synthesised via 1,4‐diketones or 4‐ketoacids with hydrazine . In addition, PyD also makes an essential core structure of several drugs such as cefozopran, cadralazine, cilazapril, and minaprine …”

“…[18] In addition, PyD also makes an essential core structure of several drugs such as cefozopran, cadralazine, cilazapril, and minaprine. [19][20][21] It is well-known that structure determines properties of molecules in chemistry. Although the entire heterocyclic diazine ring is the structural positional isomers of each other, [22] the challenge of the decade lies on the structural preference of pyrimidine (PyM) as a core component of DNA base over its other isomeric form, Pyrazine (PyA) and Pyridazine (PyD) and thus a systematic study on its molecular properties is crucial for better chemistries and building blocks of life.…”