Development of stimuli-responsive chitosan based hydrogels with anticancer efficacy, enhanced antibacterial characteristics, and applications for controlled release of benzocaine

Raza, Muhammad Asim; Gull, Nafisa; Lee, Se‐Won; Seralathan, Kamala-Kannan; Park, Sang Hyun

doi:10.1016/j.jiec.2022.02.004

Cited by 13 publications

(2 citation statements)

References 70 publications

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“…To study the possibility of the release of physiologically active substances from the gel under different pH, benzocaine was chosen as a model drug. The latter is a well-known local anesthetic and, because it contains a primary amino group, is suitable for conjugation [ 39 ]. Figure 5 a shows a scheme for the formation of a pH-sensitive imine bond between the aldehyde groups of the hydrogel and the amino group of benzocaine.…”

Section: Resultsmentioning

confidence: 99%

Fibrillar Hydrogel Based on Cellulose Nanocrystals Crosslinked via Diels–Alder Reaction: Preparation and pH-Sensitive Release of Benzocaine

Morozova,

Korzhikova-Vlakh

2023

Polymers

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A fibrillar hydrogel was obtained by covalent crosslinking via Diels–Alder reaction of two types of cellulose nanocrystals (CNCs) with furan and maleimide groups. Gelation has been studied at various ratios of components and temperatures in the range from 20 to 60 °C. It was shown that the rheological properties of the hydrogel can be optimized by varying the concentration and ratio of components. Due to the rigid structure of the CNCs, the hydrogel could be formed at a concentration of at least 5 wt%; however, it almost does not swell either in water with pH 5 or 7 or in the HBSS buffer. The introduction of aldehyde groups into the CNCs allows for the conjugation of physiologically active molecules containing primary amino groups due to the formation of imine bonds. Here, we used benzocaine as a model drug for conjugation with CNC hydrogel. The resulting drug-conjugated hydrogel demonstrated the stability of formulation at pH 7 and a pH-sensitive release of benzocaine due to the accelerated hydrolytic cleavage of the imine bond at pH < 7. The developed drug-conjugated hydrogel is promising as wound dressings for local anesthesia.

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Section: Resultsmentioning

confidence: 99%

Fibrillar Hydrogel Based on Cellulose Nanocrystals Crosslinked via Diels–Alder Reaction: Preparation and pH-Sensitive Release of Benzocaine

Morozova,

Korzhikova-Vlakh

2023

Polymers

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“…Chitosan and the crosslinker interact chemically to form the Si-N bond, which is shown by the existence of the 1240 cm -1 band. The Si-O bond vibration also corresponds to the 1089 and 920cm -1 bands, showing chemical crosslinking between the crosslinker and components (Rahma et al 2016;Raza et al 2022;Safo et al 2019).…”

Section: Ftirmentioning

confidence: 96%

Development of pomegranate peel extract amalgamated ternary hydrogel with synergistic antibacterial efficacy against Escherichia Coli (E.Coli)

Andlib,

Shafiq,

Sabir

2024

Preprint

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This study generated and assessed a series of novel combinations made of chitosan (CS), poly (vinyl pyrolidine (PVP) and guar gum (GG). By using a casting solution approach several combinations were synthesized by keeping constant CS, GG and PVP with various concentrations of crosslinker while pomegranate extract concentration was kept constant. The study also looked at the blends behaviour when they swelled and their antibacterial qualities. Significant antibacterial action was shown by the produced blends against microorganisms including, Escherichia coli due to presence of pomegranate extract. In the fabricated hydrogel the polymers strong intermolecular bonds were confirmed by FTIR. The blends swelling behaviour revealed that crosslinking(γ-APTES) had an impact on their hydrophilicity, CPG 4 showing outstanding swelling time. The information gathered from all characterization suggests that ternary novel pH sensitive hydrogel of Guar gum, CS, and PVP have the potential to be used as drug carrier as well as could be used for other biological applications like for wound healing due to its incredible antibacterial response.

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Structure and Properties of Cellulose Strengthened Poly(Acrylic Acid) Hydrogels

Chen,

Zhao,

et al. 2024

Macro Materials & Eng

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Poly(acrylic acid) (PAAc) hydrogels are essential functional materials. However, their mechanical properties do not meet the required standards. In this study, a one‐pot method is employed to prepare cellulose‐reinforced PAAc hydrogels by dissolving allyl cellulose (AC) in acrylic acid (AAc) solutions. Fourier transform infrared (FTIR), solid‐state 13C nuclear magnetic resonance (NMR), and thermogravimetric (TG) analysis are used to demonstrate that the incorporation of AC results in the formation of covalent and hydrogen bonds, which contribute to the crosslink network of the PAAc hydrogels. Significantly, by modifying the ratio of AC to AAc in the pre‐polymerization solution, the prepared AC–PAAc hydrogels exhibit a transition from transparent to opaque. This suggests that phase separation is induced by hydrogen bonding. The occurrence of phase separation is verified by observing the hydrogel microstructures using scanning electron microscopy. Phase separation leads to enhanced polymer–polymer interactions in the hydrogels, resulting in a maximum fracture stress of 2.34 MPa. The AC–PAAc hydrogels display distinct swelling behavior under various pH conditions. Moreover, they demonstrate differences in transparency and mechanical properties when exposed to dimethyl sulfoxide (DMSO) and water, indicating their responsiveness to solvents. This work demonstrates the great potential of enhancing the mechanical performance and responsiveness of PAAc hydrogels.

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Development of stimuli-responsive chitosan based hydrogels with anticancer efficacy, enhanced antibacterial characteristics, and applications for controlled release of benzocaine

Cited by 13 publications

References 70 publications

Fibrillar Hydrogel Based on Cellulose Nanocrystals Crosslinked via Diels–Alder Reaction: Preparation and pH-Sensitive Release of Benzocaine

Fibrillar Hydrogel Based on Cellulose Nanocrystals Crosslinked via Diels–Alder Reaction: Preparation and pH-Sensitive Release of Benzocaine

Development of pomegranate peel extract amalgamated ternary hydrogel with synergistic antibacterial efficacy against Escherichia Coli (E.Coli)

Structure and Properties of Cellulose Strengthened Poly(Acrylic Acid) Hydrogels

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