Development of pomegranate peel extract amalgamated ternary hydrogel with synergistic antibacterial efficacy against Escherichia Coli (E.Coli)

Abstract

This study generated and assessed a series of novel combinations made of chitosan (CS), poly (vinyl pyrolidine (PVP) and guar gum (GG). By using a casting solution approach several combinations were synthesized by keeping constant CS, GG and PVP with various concentrations of crosslinker while pomegranate extract concentration was kept constant. The study also looked at the blends behaviour when they swelled and their antibacterial qualities. Significant antibacterial action was shown by the produced blends against microorganisms including, Escherichia coli due to presence of pomegranate extract. In the fabricated hydrogel the polymers strong intermolecular bonds were confirmed by FTIR. The blends swelling behaviour revealed that crosslinking(γ-APTES) had an impact on their hydrophilicity, CPG 4 showing outstanding swelling time. The information gathered from all characterization suggests that ternary novel pH sensitive hydrogel of Guar gum, CS, and PVP have the potential to be used as drug carrier as well as could be used for other biological applications like for wound healing due to its incredible antibacterial response.