Development of starch-gelatin complex microspheres as sustained release delivery system

Narayanan, Vedha Hari B; Praneetha, T; Prathyusha, T.; Mounika, K.; Devi, D. Ramya

doi:10.4103/2231-4040.101015

Cited by 14 publications

(6 citation statements)

References 10 publications

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“…Table 2 lists some general applications of starch. [31], jackfruit seed powder (B) [32] and Scanning electron microscopy (SEM) of jackfruit seed starch-sodium alginate optimized formulation (C) [33] [36] Glucose syrup:…”

Section: Applicabilitymentioning

confidence: 99%

New Starches are the Trend for Industry Applications: A Review

Santana¹,

Meireles²

2014

fph

149

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Starch is widely consumed by humans as an inexpensive and stable available carbohydrate source, and much work has been performed on the structure, functionality and applicability of starches. Although conventional sources of starch, such as corn and potato, other sources with improved properties are becoming significant to allow simpler and more robust processes. The feasibility of the use of new starches, i.e., legume, seed and palm, as renewable materials for commercial application may provide cost reduction of raw material in industries. Little information is available on the structure, properties and practical applicability of non-conventional sources of starch. Thus, it is necessary that these starches be studied to obtain and report their structural parameters, information that is required to gain competitiveness in an international-scale industry. A review of properties, applications, future trends and perspectives of some new starches is presented in this review.

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Section: Applicabilitymentioning

confidence: 99%

New Starches are the Trend for Industry Applications: A Review

Santana¹,

Meireles²

2014

fph

149

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“…In contrast to CDs, SPs offer a low cost alternative as carrier systems for agrochemicals, pharmaceuticals, cosmetics, food, and as scaffolds for tissue regeneration. 22 SPs are potential adsorbents and carriers for diverse guest species according to the variable adsorption− desorption properties with model dye systems. 23 The textural and surface properties of SPs enhance their wettability, 24 conformational flexibility, and ability to form host−guest complexes.…”

Section: ■ Introductionmentioning

confidence: 99%

Renewable Starch Carriers with Switchable Adsorption Properties

Karoyo

Dehabadi

Wilson

2018

ACS Sustainable Chem. Eng.

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This Research Article describes a systematic study on the structure and sorption properties of Carnation-based starch-particles (SPs) by various techniques. Structural characterization of the SPs utilized spectroscopy (1H NMR and FT-IR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA). The sorption properties of the SPs were characterized by solvent swelling and uptake isotherms with cationic adsorbates at equilibrium and kinetic conditions. The surface area (SA; ∼3–588 m2/g) of the SPs was estimated using nitrogen gas and dye adsorption isotherm methods, where the range in SA was related to solvent swelling effects on the textural properties. The SPs contain lipid constituents according to results obtained by 1H NMR spectroscopy, DSC, and confocal laser microscopy (CLM) with iodine staining. The unique solvent swelling properties of the SPs reveal greater swelling in water over ethanol. SPs display preferential equilibrium uptake of methylene blue (MB; Q m ≈ 716 mg/g) over cetylpyridinium bromide (CPB; Q m ≈ 292 mg/g). The uptake of MB was reduced by an order of magnitude (Q m ≈ 67 mg/g) when the SPs were doped with CPB, further revealing the role of competitive adsorption and similar binding modes for MB and CPB. The doping of SPs with CPB provide a facile approach for alteration of the surface functional properties such as the hydrophile–lipophile character, surface charge, and hydration properties of the SPs. Evidence of monolayer and multilayer adsorption of CPB onto SPs lead to switchable adsorption properties where such amphiphile surface patterning can be harnessed to yield materials with unique controlled-release properties for diverse chemical systems according to tunable surface charge using self-assembly.

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“…Accurately weighed (50 mg) washed microspheres were crushed in a glass mortar pestle and the powdered microspheres were suspended in 10 ml of methanol and kept for 12 h. After filtration appropriate dilution were made with methanol and the absorbance was measured spectrophotometrically at 424 nm against blank. The entrapment efficiency was calculated using the following formula:[ 18 ]…”

Section: Methodsmentioning

confidence: 99%

Mucoadhesive microparticulate drug delivery system of curcumin against Helicobacter pylori infection: Design, development and optimization

Ali¹,

Pandit²,

Jain³

et al. 2014

J Adv Pharm Technol Res

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The purpose of the present research was to develop and characterize mucoadhesive microspheres of curcumin for the potential use of treating gastric adenocarcinoma, gastric and duodenal ulcer associated with Helicobacter pylori. Curcumin mucoadhesive microspheres were prepared using ethyl cellulose as a matrix and carbopol 934P as a mucoadhesive polymer by an emulsion-solvent evaporation technique. Response surface methodology was used for optimization of formulation using central composite design (CCD) for two factors at three levels each was employed to study the effect of independent variables, drug:polymer:polymer ratio (curcumin:ethylcellulose:carbopol 934P)(X1) and surfactant concentration (X2) on dependent variables, namely drug entrapment efficiency (DEE), percentage mucoadhesion (PM), in vitro drug release and particle size (PS). Optimized formulation was obtained using desirability approach of numerical optimization. The experimental values of DEE, PM, % release and PS after 8 h for the optimized formulation were found to be 50.256 ± 1.38%, 66.23%±0.06, 73.564 ± 1.32%, and 139.881 ± 2.56 μm, respectively, which were in close agreement with those predicted by the mathematical models. The drug release was also found to be slow and extended more than 8 h and release rates were fitted to the Power law equation and Higuchi model to compute the diffusional parameters. The prolonged stomach residence time of curcumin mucoadhesive microspheres might make a contribution to H. pylori complete eradication in combination with other antimicrobial agents.

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Development of starch-gelatin complex microspheres as sustained release delivery system

Cited by 14 publications

References 10 publications

New Starches are the Trend for Industry Applications: A Review

New Starches are the Trend for Industry Applications: A Review

Renewable Starch Carriers with Switchable Adsorption Properties

Mucoadhesive microparticulate drug delivery system of curcumin against Helicobacter pylori infection: Design, development and optimization

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