Development of starch/chitosan expandable films as a gastroretentive carrier for ginger extract-loaded solid dispersion

Kaewkroek, Kanidta; Petchsomrit, Arpa; Septama, Abdi Wira; Wiwattanapatapee, Ruedeekorn

doi:10.1016/j.jsps.2021.12.017

Cited by 13 publications

(12 citation statements)

References 49 publications

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“…Film tensile strength (TS) was measured using a texture analyzer (TA.XT plus, Stable Micro Systems; Charpa Techcenter Co. Ltd., Bangkok, Thailand) equipped with a 25 kg load cell following the method described by Kaewkroek et al [12,42]. Rectangular test samples (60 × 10 mm) free of air bubbles and other physical imperfections were clamped 30 mm apart and extended at a rate of 2.0 mm/s until the film ruptured.…”

Section: Film Tensile Strengthmentioning

confidence: 99%

“…The poor aqueous solubility and dissolution rate of curcumin may be improved by the formulation of solid dispersions. This strategy involves intimate mixing of hydrophilic polymers and bioactive compounds, for example, from plants, including curcumin, resveratrol, quercetin, and glycosides [9][10][11][12][13]. The bioavailability of curcumin may be further enhanced by employing gastroretentive drug delivery systems, which are designed to extend residence times in the stomach, resulting in prolonged drug release and thereby improving bioavailability.…”

Section: Introductionmentioning

confidence: 99%

“…To date, there has been very little research reported on the application of starch blend films as a gastroretentive drug carrier [11,12]. The aim of this study, in particular, was to develop expandable films based on blends of chitosan with mung bean starch, pregelatinized starch, corn starch, or banana starch as a carrier for curcumin solid dispersion prepared using Eudragit ® EPO as the hydrophilic polymer.…”

Section: Introductionmentioning

confidence: 99%

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Development of Gastroretentive Carriers for Curcumin-Loaded Solid Dispersion Based on Expandable Starch/Chitosan Films

et al. 2023

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Curcumin, a polyphenolic extract from the rhizomes of turmeric, exhibits antioxidant, anti-inflammatory, and anticancer activities, which are beneficial for the treatment of gastric diseases. However, curcumin’s therapeutic usefulness is restricted by its low aqueous solubility and short gastric residence time. In this study, curcumin-loaded solid dispersion (ratio 1:5) was prepared using Eudragit® EPO (Cur EPO-SD), resulting in an approximately 12,000-fold increase in solubility to 6.38 mg/mL. Expandable films incorporating Cur EPO-SD were subsequently prepared by solvent casting using different types of starch (banana, corn, pregelatinized, and mung bean starch) in combination with chitosan. Films produced from banana, corn, pregelatinized and mung bean starch unfolded and expanded upon exposure to simulated gastric medium, resulting in sustained release of 80% of the curcumin content within 8 h, whereas films based on pregelatinized starch showed immediate release characteristics. Curcumin-loaded expandable films based on different types of starch exhibited similar cytotoxic effects toward AGS cells and more activity than unformulated curcumin. Furthermore, the films resulted in increased anti-inflammatory activity against RAW 264.7 macrophage cells compared with the NSAID, indomethacin. These findings demonstrate the potential of expandable curcumin-loaded films as gastroretentive dosage forms for the treatment of gastric diseases and to improve oral bioavailability.

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Section: Film Tensile Strengthmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of Gastroretentive Carriers for Curcumin-Loaded Solid Dispersion Based on Expandable Starch/Chitosan Films

et al. 2023

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“…Accurate determination of a film thickness measurement is essential for determining tensile strength and water vapor permeability. Film thicknesses of starch-chitosan films presented in the literature are most commonly seen in the range of 50 to 100 μm, but depending on the amount of ingredients added and synthesis methodology, have been reported up to 800 μm. ,, …”

Section: Film Characterization and Analysismentioning

confidence: 99%

“…Film thicknesses of starch-chitosan films presented in the literature are most commonly seen in the range of 50 to 100 μm, but depending on the amount of ingredients added and synthesis methodology, have been reported up to 800 μm. 43,59,60 4.2. Color and Opacity.…”

Section: Film Thicknessmentioning

confidence: 99%

A Review of the Current and Future Prospects for Producing Bioplastic Films Made from Starch and Chitosan

Nguyen,

Escribà-Gelonch,

Hessel

et al. 2024

ACS Sustainable Chem. Eng.

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This review presents a summary of plastic films made from two abundant natural polymers, starch and chitosan. Films possess many useful attributes such as transparency, good physical strength, and barrier properties. Modifications are being investigated to improve the properties of the product such as reinforcement with nanoparticles, strengthening by cross-linking, and applying surface coatings to improve interfacial properties. We provide perspectives on the use of starch chitosan films as a biobased, biodegradable food packaging material. Additionally, a detailed life-cycle assessment compares the production of chitosan-based polymers to other bioplastics and petroleum-based alternatives. Finally, we predict which factors will be important in the future for making the production of chitosan films economically and environmentally sustainable.

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Investigating the synthesized sodium gluconate‐loaded chitosan microspheres on mild steel corrosion inhibition in acidic medium

Zhang

2022

Applied Organom Chemis

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In this research, the sodium gluconate‐loaded chitosan microspheres (SG/CM) are prepared by negative pressure impregnation after chitosan (CS) hydrothermally synthesized with vanillin (VA) to form chitosan microspheres (CM), which is in shape of ellipsoidal spheroid. The structures of the prepared micron materials are investigated by Fourier transform infrared spectroscopy (FTIR), while tungsten filament scanning electron microscopy (SEM) and transmission electron microscopy (TEM) are used to characterize the morphology of the prepared. Moreover, the thermogravimetric characterization reveals that loading sodium gluconate made it more thermally stable. The corrosion inhibition performance of CS, CM, and SG/CM is investigated in 0.1 mol/L HCl by electrochemical impedance spectroscopy (EIS), indicating an increase efficiency for inhibitors at higher concentrations, and the optimum is achieved by SG/CM at 200 mg/L, corresponding to weight loss measurements. The potentiodynamic polarization (PDP) test shows the best inhibition efficiency, 92.01% for SG/CM, which is superior to 52.23% for CS and 75.91% for CM. The surface features of corroded samples are investigated by Leica optical microscopy. Additionally, the inhibition mechanism of SG/CM is studied by building the Langmuir adsorption model, revealing that the inhibitory molecule occupies only one site on the themetallic surface.

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Development of starch/chitosan expandable films as a gastroretentive carrier for ginger extract-loaded solid dispersion

Cited by 13 publications

References 49 publications

Development of Gastroretentive Carriers for Curcumin-Loaded Solid Dispersion Based on Expandable Starch/Chitosan Films

Development of Gastroretentive Carriers for Curcumin-Loaded Solid Dispersion Based on Expandable Starch/Chitosan Films

A Review of the Current and Future Prospects for Producing Bioplastic Films Made from Starch and Chitosan

Investigating the synthesized sodium gluconate‐loaded chitosan microspheres on mild steel corrosion inhibition in acidic medium

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