Development of Solid-Self Micron Emulsifying Drug Delivery Systems

Abstract

As a consequence of modern drug discovery techniques, there has been a steady increase in the number of new pharmacologically active lipophilic compounds that are poorly water soluble and solubility is one of the most important parameter to achieve desired concentration of drug in systemic circulation for therapeutic response. It is a great challenge for pharmaceutical scientist to convert those molecules into orally administered formulation with sufficient bioavailability. Among the several approaches to improve oral bioavailability of these molecules, Self-micron emulsifying drug delivery system (SMEDDS) is one of the approaches usually used to improve the bioavailability of hydrophobic drugs. However, conventional SMEDDS are mostly prepared in a liquid form, which can have several disadvantages. Accordingly, solid SMEDDS (S-SMEDDS) prepared by solidification of liquid/semisolid self-micron emulsifying (SME) ingredients into powders have gained popularity. This article provides an overview of the recent advancements in S-SMEDDS such as methodology, techniques and future research directions.

Development and Evaluation of Self Micro-Emulsifying Formulation of Venlafaxine HCl with Improved Antidepressant Activity

“…The saturated solutions were then centrifuged at 3500 rpm for 20 min and supernatant was analyzed for drug content after appropriate dilution with methanol at 276 nm using UV spectrophotometry. [17][18][19][20][21][22]…”

“…Thermodynamic stability studies [17][18][19][20] These studies included exposure of formulation to thermal (both low and high) as well as mechanical stress and observing the effects on the self-emulsification ability and clarity of the SMEDDS formulation. The test was carried out in two parts:…”

“…Differential Scanning Calorimetry (DSC) 18,31,33 A differential scanning calorimetry analysis was used to characterize physical state of drug in solid SMEDDS. The DSC patterns were recorded on a Mettler Toledo DSC Star system.…”

A review on micro beads: Formulation, technological aspects, and extraction

“…Microparticles extracted from facial/body scrubs [24] After filtering, the beads were cleaned with distilled water, dried, and their weight, size, and form were examined. An ABT 220-5DM electronic balance (detection limit: 0.01 mg) was used to weigh the beads.…”