Development of sodium alginate-xanthan gum based nanocomposite scaffolds reinforced with cellulose nanocrystals and halloysite nanotubes

Kumar, Anuj; Rao, Kummara Madhusudana; Han, Sung Soo

doi:10.1016/j.polymertesting.2017.08.030

Cited by 88 publications

(38 citation statements)

References 42 publications

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“…Synergistic interactions between gum mixtures have attracted wide attention in food industry because they can improve rheological, mechanical, and barrier properties of products [10]. Frequently, xanthan gum (XG) was mixed with other biopolymers to change the viscosity of biopolymers, due to the synergistic interaction between them [10][11][12][13]. Furthermore, XG can improve mechanical properties and water vapor permeability of protein edible films [14].…”

Section: Introductionmentioning

confidence: 99%

Effect of Gellan Gum and Xanthan Gum Synergistic Interactions and Plasticizers on Physical Properties of Plant-Based Enteric Polymer Films

Zhang

et al. 2020

Polymers

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The mechanical and barrier properties of plant-based enteric polymer films were enhanced by synergistic interactions between binary gum mixtures and adding plasticizers. The results indicated that the best ratio of gellan gum (GG) and xanthan gum (XG) was 7:3 by comparing tensile strength, tensile elongation, transmittance, and water vapor permeability of plant-based enteric polymer films and rheological properties of solutions. Polyethylene glycol 400 (PEG-400) was an effective plasticizer in improving plasticity and water vapor barrier property of the plant-based enteric polymer film. Rheology measurement and different characterization methods, including Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry, X-ray diffraction, and scanning electron microscopy, were used to explain interactions between GG and XG as well as PEG-400 and components of the film. The new mixed system, composed of GG/XG mixture with ratio of 7:3 as a novel gelling agent and PEG-400 as a plasticizer, was applied to prepare plant-based enteric hard capsules, which have potential applications in medicines and functional food preparations.

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Section: Introductionmentioning

confidence: 99%

Effect of Gellan Gum and Xanthan Gum Synergistic Interactions and Plasticizers on Physical Properties of Plant-Based Enteric Polymer Films

Zhang

et al. 2020

Polymers

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“…The incorporation of cellulose nanocrystals (CNCs) in XG/silica glass (SG) scaffolds showed tunable and improved mechanical properties with good pre-osteoblast MC3T3-E1 cells cytocompatibility [165]. In addition, the effect of variable amounts of CNCs and/or HNTs on sodium alginate (SA)/XG (SAX) scaffolds also showed improved thermal stability, mechanical properties (under compression), and in vitro cytocompatibility with MC3T3-E1 osteoblastic cells as compared to SA and SAX scaffolds [166]. By the co-precipitation method, Bael fruit gum (BFG)-CS/HAp nanocomposite scaffolds have been prepared.…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

Recent Advances in Natural Gum-Based Biomaterials for Tissue Engineering and Regenerative Medicine: A Review

et al. 2020

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The engineering of tissues under a three-dimensional (3D) microenvironment is a great challenge and needs a suitable supporting biomaterial-based scaffold that may facilitate cell attachment, spreading, proliferation, migration, and differentiation for proper tissue regeneration or organ reconstruction. Polysaccharides as natural polymers promise great potential in the preparation of a three-dimensional artificial extracellular matrix (ECM) (i.e., hydrogel) via various processing methods and conditions. Natural polymers, especially gums, based upon hydrogel systems, provide similarities largely with the native ECM and excellent biological response. Here, we review the origin and physico-chemical characteristics of potentially used natural gums. In addition, various forms of scaffolds (e.g., nanofibrous, 3D printed-constructs) based on gums and their efficacy in 3D cell culture and various tissue regenerations such as bone, osteoarthritis and cartilage, skin/wound, retinal, neural, and other tissues are discussed. Finally, the advantages and limitations of natural gums are precisely described for future perspectives in tissue engineering and regenerative medicine in the concluding remarks.

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“…Although, there was a shift in sedimentation coefficient values of the peaks over the period of two weeks and temperature of incubation (Table 3), the number of peaks remained constant, with an exception at 37 • C on day 7 for PIC complex. Therefore, it was concluded that interactions among PIC component were stable and the complex did not disintegrate at lower temperature for the tested timeframe (day [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. It is possible that at 37 • C the complex either dissociated or microbial growth would have occurred.…”

Section: Sedimentation Velocitymentioning

confidence: 99%

“…Its main chain consists of β-D-glucose units linked at the 1 and 4 positions. Side-chains consist of a tri-saccharide composed of mannose (β-1,4) glucuronic acid and (β-1,2) mannose, attached to alternate glucose residues in the backbone by α-1,3 linkages [8,9].Xanthan gum and alginate complexes (XA) have been studied previously [10] and used for functional foods [11], tissue engineering [3,12,13] and drug delivery. As negatively charged polymers, xanthan [14][15][16][17] and alginate [18][19][20] have been used separately, and in combination with positively charged polymers such as chitosan, as potential vehicles for insulin delivery.Interactions among different types of protein-polysaccharide complexes (PPCs) have been previously investigated using a variety of methods [21,22].…”

mentioning

confidence: 99%

“…Xanthan gum and alginate complexes (XA) have been studied previously [10] and used for functional foods [11], tissue engineering [3,12,13] and drug delivery. As negatively charged polymers, xanthan [14][15][16][17] and alginate [18][19][20] have been used separately, and in combination with positively charged polymers such as chitosan, as potential vehicles for insulin delivery.…”

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confidence: 99%

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Clinically Relevant Insulin Degludec and Its Interaction with Polysaccharides: A Biophysical Examination

et al. 2020

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Protein polysaccharide complexes have been widely studied for multiple industrial applications and are popular due to their biocompatibility. Insulin degludec, an analogue of human insulin, exists as di-hexamer in pharmaceutical formulations and has the potential to form long multi-hexamers in physiological environment, which dissociate into monomers to bind with receptors on the cell membrane. This study involved complexation of two negatively charged bio-polymers xanthan and alginate with clinically-relevant insulin degludec (PIC). The polymeric complexations and interactions were investigated using biophysical methods. Intrinsic viscosity [η] and particle size distribution (PSD) of PIC increased significantly with an increase in temperature, contrary to the individual components indicating possible interactions. [η] trend was X > XA > PIC > A > IDeg. PSD trend was X > A > IDeg > XA > PIC. Zeta (ζ)-potential (with general trend of IDeg < A < XA < X ≈ PIC) revealed stable interaction at lower temperature which gradually changed with an increase in temperature. Likewise, sedimentation velocity indicated stable complexation at lower temperature. With an increase in time and temperature, changes in the number of peaks and area under curve were observed for PIC. Conclusively, stable complexation occurred among the three polymers at 4 • C and 18 • C and the complex dissociated at 37 • C. Therefore, the complex has the potential to be used as a drug delivery vehicle.Polymers 2020, 12, 390 2 of 15 Alginates (A) are linear polymers of 1,4-linked β-D-mannuronic acid residues and 1,4-linked α-L-guluronic residues, containing homo-polymeric sequences [7]. Xanthan (X) is composed of D-glucosyl, D-mannosyl, and D-glucuronyl acid residues in a 2:2:1 molar ratio and variable proportions of O-acetyl and pyruvyl residues. Its main chain consists of β-D-glucose units linked at the 1 and 4 positions. Side-chains consist of a tri-saccharide composed of mannose (β-1,4) glucuronic acid and (β-1,2) mannose, attached to alternate glucose residues in the backbone by α-1,3 linkages [8,9].Xanthan gum and alginate complexes (XA) have been studied previously [10] and used for functional foods [11], tissue engineering [3,12,13] and drug delivery. As negatively charged polymers, xanthan [14][15][16][17] and alginate [18][19][20] have been used separately, and in combination with positively charged polymers such as chitosan, as potential vehicles for insulin delivery.Interactions among different types of protein-polysaccharide complexes (PPCs) have been previously investigated using a variety of methods [21,22]. The formation and dissociation of PPCs and their solubility depend on many factors such as surface charge, pH, temperature and ionic strength of the solvent [23]. These factors greatly influence non-covalent interactions such as electrostatic, H-bonding, hydrophobic, and steric interactions, as well as covalent interactions [24]. Conjugation of polysaccharides with therapeutic proteins is a well-established phenomenon [25]. In particul...

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Development of sodium alginate-xanthan gum based nanocomposite scaffolds reinforced with cellulose nanocrystals and halloysite nanotubes

Cited by 88 publications

References 42 publications

Effect of Gellan Gum and Xanthan Gum Synergistic Interactions and Plasticizers on Physical Properties of Plant-Based Enteric Polymer Films

Effect of Gellan Gum and Xanthan Gum Synergistic Interactions and Plasticizers on Physical Properties of Plant-Based Enteric Polymer Films

Recent Advances in Natural Gum-Based Biomaterials for Tissue Engineering and Regenerative Medicine: A Review

Clinically Relevant Insulin Degludec and Its Interaction with Polysaccharides: A Biophysical Examination

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