Development of silver nanoparticle-based hydrogel composites for antimicrobial activity

Abstract

2020) Development of silver nanoparticle-based hydrogel composites for antimicrobial activity, Green Chemistry Letters and Reviews, 13:1, 34-40, ABSTRACT Antimicrobial function of Ag nanoparticles (NPs) has a strong correlation with the released Ag + cations that are produced by oxidation of Ag NPs in a solution state under ambient condition. Therefore, in order to develop anti-infective materials for biomedical applications, one needs to include Ag NPs inside biocompatible materials, which can allow slow release of Ag + cations. Hydrogels of natural polymers could be an ideal choice for the purpose because (a) the physicochemical properties of hydrogels resemble with biological tissue, and (b) the inclusion of Ag NPs inside hydrogels prevents the direct release of Ag NPs, while allowing the release of Ag + cations out of the hydrogels. In this regard, we present a simple strategy for producing Ag NPscontaining hydrogel based on natural alginate polymers. The chemical modification of alginate, blending with Ag NPs, gelation by photo-crosslinking process have been discussed in connection with antimicrobial reaction on model bacterium.

Light and Hydrogels: A New Generation of Antimicrobial Materials

“…These last studies demonstrated that NPs of silver play thus a dual antibacterial role: for colloidal silver NPs, the bactericidal action would be due to the formation of Ag + cations from the NPs by an oxidation reaction, given that Ag + ions disrupt bacterial cell membranes and inhibit the enzymatic activity of bacterial cells [ 43 ]. In addition, silver NPs themselves feature antibacterial properties; they could, however, be harmful to host tissues, making it of the utmost importance to prevent the release of silver NPs within infected areas.…”

“…If the last two studies introduced silver NPs via an in situ approach, by reducing Ag + cations into metal NPs during the crosslinking step of the polymerization, ensuring a homogeneous dispersion of NPs within hydrogels, Zakia et al used an ex situ approach, consisting of the mixing of presynthesized silver NPs and monomer units before the crosslinking [ 43 ]. To prevent NP agglomeration from occurring during the crosslinking process, reducing hence the antibacterial efficacy of silver NPs, their surface can be modified, by proteins such as collagen, for instance, to enhance stabilization within hydrogel networks before gelation occurs [ 83 ].…”

“…Their tunable mechanical and rheological properties, their sensitivity towards external stimuli and their ability to provide a moist environment and high levels of biocompatibility make them particularly interesting materials in the pharmaceutical and biomedical worlds [ 34 , 37 , 38 ]. Their extensive usage ranges from tissue engineering [ 39 , 40 ], wound dressing [ 37 , 41 , 42 ], antibacterial coatings [ 43 , 44 , 45 ], contact lenses [ 46 , 47 ], drug delivery systems [ 48 , 49 ], super-absorbents [ 35 , 50 , 51 ], biomedical implants [ 52 ] as well as a great number of other therapeutic applications [ 34 , 53 ], to miscellaneous applications such as biosensors [ 54 ], microelectromechanical devices [ 35 ], electrical conduction [ 55 ], energy storage devices [ 56 , 57 ], purification of water and decontamination of organic waste [ 50 , 56 , 58 , 59 ], food and agricultural applications [ 60 ].…”

Physiochemical synthesis of Silver/Kaolinite nanocomposites and study their antibacterial properties

“…1. The silver surface plasmon resonance (SPR) bands were identified around 400 nm for both Ag/Kln NCs that can be assigned as SPR of Ag NCs [35,36]. The UV-visible absorption spectra depends mainly on the morphology, structure and size of the NCs [36].…”

“…The absorbance is directly proportional to the concentration of the nanoparticles, indicating that the absorbance of maximum absorption wavelength (kmax) increases with an increase in the number of nanoparticles. Based on this theory, nanoparticles with different sizes indicate different optical properties due to the difference in the surface plasmon resonance bands [35].…”