Development of shape memory polymer nanocomposite foam for treatment of intracranial aneurysms

Wang, Jingyu; Luo, Jishan; Kunkel, Robert; Saha, Mrinal C.; Bohnstedt, Bradley N.; Lee, Chung‐Hao; Liu, Yingtao

doi:10.1016/j.matlet.2019.04.112

Cited by 23 publications

(29 citation statements)

References 9 publications

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“…Therefore, it is urgently required to develop biocompatible and degradable SMPs with adequate tensile properties to fabricate novel kinds of medical devices [11,12,13]. In 2017, the Becker group [14] provided an overview of SMPs being used in medical applications, and after that, a large number of works related to biocompatible SMPs have been published [15,16,17].…”

Section: Introductionmentioning

confidence: 99%

Degradable Poly(ether-ester-urethane)s Based on Well-Defined Aliphatic Diurethane Diisocyanate with Excellent Shape Recovery Properties at Body Temperature for Biomedical Application

et al. 2019

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The aim of this study is to offer a new class of degradable shape-memory poly(ether-ester-urethane)s (SMPEEUs) based on poly(ether-ester) (PECL) and well-defined aliphatic diurethane diisocyanate (HBH) for further biomedical application. The prepolymers of PECLs were synthesized through bulk ring-opening polymerization using ε-caprolactone as the monomer and poly(ethylene glycol) as the initiator. By chain extension of PECL with HBH, SMPEEUs with varying PEG content were prepared. The chemical structures of the prepolymers and products were characterized by GPC, 1H NMR, and FT-IR, and the effect of PEG content on the physicochemical properties (especially the shape recovery properties) of SMPEEUs was studied. The microsphase-separated structures of the SMPEEUs were demonstrated by DSC and XRD. The SMPEEU films exhibited good tensile properties with the strain at a break of 483%–956% and an ultimate stress of 23.1–9.0 MPa. Hydrolytic degradation in vitro studies indicated that the time of the SMPEEU films becoming fragments was 4–12 weeks and the introduction of PEG facilitates the degradation rate of the films. The shape memory properties studies found that SMPEEU films with a PEG content of 23.4 wt % displayed excellent recovery properties with a recovery ratio of 99.8% and a recovery time of 3.9 s at body temperature. In addition, the relative growth rates of the SMPEEU films were greater than 75% after incubation for 72 h, indicating good cytocompatibility in vitro. The SMPEEUs, which possess not only satisfactory tensile properties, degradability, nontoxic degradation products, and cytocompatibility, but also excellent shape recovery properties at body temperature, promised to be an excellent candidate for medical device applications.

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Section: Introductionmentioning

confidence: 99%

Degradable Poly(ether-ester-urethane)s Based on Well-Defined Aliphatic Diurethane Diisocyanate with Excellent Shape Recovery Properties at Body Temperature for Biomedical Application

et al. 2019

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“…The presence of the CNT allows for expansion of the shape-memory foam through resistive heating. [77] Shape-memory polymers also hold potential for the treatment of endovascular thromboses. For example, Small et al have reported on a shape-memory device that combines nitinol with a shape-memory polymer to create a device that is able to remove blood cloths in an in vitro context.…”

Section: Cardiovascular Applications Of Shape-memory Polymersmentioning

confidence: 99%

“…The presence of the CNT allows for expansion of the shape‐memory foam through resistive heating. [ 77 ]…”

Section: Biomedical Applications Of Shape‐memory Polymersmentioning

confidence: 99%

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Shape‐Memory Polymers for Biomedical Applications

Delaey

Dubruel

Vlierberghe

2020

Adv Funct Materials

207

160

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One of the most promising fields for shape-memory polymers is the biomedical field. Shape-memory polymers that can be triggered by various (physiological) conditions such as temperature and moisture have been reported, as well as remotely triggerable shape-memory polymers that make use of electromagnetic fields, ultrasound, etc. These polymers have shown great promise in in vitro studies as well as in early in vivo studies. Their biocompatibility, and in some cases biodegradability, renders them excellent candidates for minimal invasive surgery and for the design of triggerable biomedical devices. The current review provides a nonexhaustive overview of recent developments realized throughout the last decade in the field of shapememory polymers serving specific biomedical applications while considering relevant triggers and biocompatible chemistries.

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“…The elastic response of polymer foams has attracted substantial attention, because these materials demonstrate excellent material properties (ease of processing, low production cost, high specific strength and energy adsorption, good chemical resistance, low density, dielectric constants, and thermal conductivity). Applications of polymer foams range from (1) composite core materials for sports equipment, interior panels in aircrafts and boats, and automotive seat cushion constructions to (2) materials for thermal isolation and acoustic absorption, to (3) porous template materials for purification of wastewater, as well as filtration, gas sorption, catalysis, and separation, to (4) drug delivery and protein encapsulation, to (5) tissue scaffolds for growth of cells and artificial organs, to (6) materials for endovascular procedures and measurement of brain activity, to (7) flexible and stretchable pressure and temperature sensors, to (8) lightweight devices for electromagnetic interference shielding, to (9) porous electrodes for solid oxide fuel cells, to (10) ferroelectrets for energy harvesting from vibration …”

Section: Introductionmentioning

confidence: 99%

The effect of porosity on elastic moduli of polymer foams

Drozdov¹,

Christiansen²

2019

J of Applied Polymer Sci

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Constitutive equations are reported for the effect of porosity on the elastic moduli and longitudinal sound speed of polymer foams. These relations are grounded on the asymptotic homogenization method combined with the integration embedding scheme. Observations are analyzed on open-cell and closed-cell porous polymers manufactured by (1) foaming with chemical blowing agents, (2) foaming with inert gases, and (3) emulsion-templating foaming. Numerical analysis of experimental data shows that changes in the elastic moduli with porosity are correctly predicted by the governing relations for foams with spherical voids. Porous polydimethylsiloxane (PDMS) elastomers prepared by the emulsion-templating method provide an exception from this rule. The difference between these materials and the other cellular polymers is caused by production of hydrogen gas under curing, which induces severe deformation of pores. Simulation reveals that experimental data on cellular PDMS elastomers are described by the differential equations for foams with spheroidal voids whose aspect ratio depends on porosity. INTRODUCTIONThe elastic response of polymer foams has attracted substantial attention, because these materials demonstrate excellent material properties (ease of processing, low production cost, high specific strength and energy adsorption, good chemical resistance, low density, dielectric constants, and thermal conductivity). Applications of polymer foams range from (1) composite core materials for sports equipment, interior panels in aircrafts and boats, 1 and automotive seat cushion constructions 2 to (2) materials for thermal isolation 3 and acoustic absorption, 4 to (3) porous template materials for purification of wastewater, 5 as well as filtration, gas sorption, catalysis, and separation, 6 to (4) drug delivery and protein encapsulation, 7 to (5) tissue scaffolds for growth of cells and artificial organs, 8 to (6) materials for endovascular procedures 9 and measurement of brain activity, 10 to (7) flexible and stretchable pressure 11 and temperature 12 sensors, to (8) lightweight devices for electromagnetic interference shielding, 13 to (9) porous electrodes for solid oxide fuel cells, 14 to (10) ferroelectrets for energy harvesting from vibration. 15

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Development of shape memory polymer nanocomposite foam for treatment of intracranial aneurysms

Cited by 23 publications

References 9 publications

Degradable Poly(ether-ester-urethane)s Based on Well-Defined Aliphatic Diurethane Diisocyanate with Excellent Shape Recovery Properties at Body Temperature for Biomedical Application

Degradable Poly(ether-ester-urethane)s Based on Well-Defined Aliphatic Diurethane Diisocyanate with Excellent Shape Recovery Properties at Body Temperature for Biomedical Application

Shape‐Memory Polymers for Biomedical Applications

The effect of porosity on elastic moduli of polymer foams

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