Development of Semi- and Grafted Interpenetrating Polymer Networks Based on Poly(Ethylene Glycol) Diacrylate and Collagen

Madaghiele, Marta; Marotta, Francesco; Demitri, Christian; Montagna, Francesco; Maffezzoli, Alfonso; Sannino, Alessandro

doi:10.5301/jabfm.5000187

Cited by 13 publications

(24 citation statements)

References 31 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such tests were carried out both to assess the mechanical properties of the samples and probing the degree of crosslinking by using the theory of rubber elasticity. Indeed, in the case of a perfect rubber‐like polymer network subjected to small uniaxial deformations (i.e., for negligible volume changes either in compression or elongation), the Flory relationship might be used to estimate the elastically effective degree of crosslinking as reported in a previous work …”

Section: Methodsmentioning

confidence: 99%

Gelatin/nano‐hydroxyapatite hydrogel scaffold prepared by sol‐gel technology as filler to repair bone defects

Raucci

Demitri

Soriente

et al. 2018

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

This study reports on the development of a scaffold with a gradient of bioactive solid signal embedded in the biodegradable polymer matrix by combining a sol-gel approach and freeze-drying technology. The chemical approach based on the sol-gel transition of calcium phosphates ensures the particles dispersion into the gelatin matrix and a direct control of interaction among COOH /Ca ions. Morphological analysis demonstrated that on the basis of the amount of inorganic component and by using specific process conditions, it is possible to control the spatial distribution of nanoparticles around the gelatin helix. In fact, methodology and formulations were able to discriminate between the different hydroxyapatite concentrations and their respective morphology. The good biological response represented by good cell attachment, proliferation and increased levels of alkaline phosphatase as an indicator of osteoblastic differentiation of human mesenchymal stem cells toward the osteogenic lineage, demonstrating the effect of bioactive solid signals on cellular behavior. Furthermore, the inhibition of reactive oxygen species production by composite materials predicted potential anti-inflammatory properties of scaffolds thus confirming their biocompatibility. Indeed, these interesting biological results suggest good potential application of this scaffold as filler to repair bone defects. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2007-2019, 2018.

show abstract

Section: Methodsmentioning

confidence: 99%

Gelatin/nano‐hydroxyapatite hydrogel scaffold prepared by sol‐gel technology as filler to repair bone defects

Raucci

Demitri

Soriente

et al. 2018

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…To date, a variety of bioinks have proved their merits in stereolithography/DMD bioprinting including PEGDA, GelMA, poly(acrylic acid) (PAA), collagen, HA, and their blends [113–115, 117, 129–131]. For example, Zhang et al directly patterned 3D microscale objects made of PEGDA into a variety of shapes, such as stepwise, spiral, embryo-like, and flower-like microstructures (Fig.…”

Section: Spatial Control Of Hydrogelsmentioning

confidence: 99%

“…For example, Suri and Schmidt patterned an IPN hybrid hydrogel by combining HA, a high-molecular weight glycosaminoglycan ubiquitously found in many cartilaginous tissues, and collagen, a major macromolecular component in the ECM, for use as scaffolds in engineering functional tissues [130]. Similarly, Madaghiele et al used a mixture of PEGDA and acrylic acid for the stereolithographic fabrication of 3D hydrogel scaffolds in the presence of collagen [129]. The grafting of collagen macromolecules through the carbodiimide chemistry to the PEGDA/PAA network further increased both the bioactivity and the mechanical properties of the resulting hydrogel constructs.…”

Section: Spatial Control Of Hydrogelsmentioning

confidence: 99%

Spatially and temporally controlled hydrogels for tissue engineering

Leijten

Seo

Yue

et al. 2017

Materials Science and Engineering: R: Reports

158

129

View full text Add to dashboard Cite

Summary Recent years have seen tremendous advances in the field of hydrogel-based biomaterials. One of the most prominent revolutions in this field has been the integration of elements or techniques that enable spatial and temporal control over hydrogels’ properties and functions. Here, we critically review the emerging progress of spatiotemporal control over biomaterial properties towards the development of functional engineered tissue constructs. Specifically, we will highlight the main advances in the spatial control of biomaterials, such as surface modification, microfabrication, photo-patterning, and three-dimensional (3D) bioprinting, as well as advances in the temporal control of biomaterials, such as controlled release of molecules, photocleaving of proteins, and controlled hydrogel degradation. We believe that the development and integration of these techniques will drive the engineering of next-generation engineered tissues.

show abstract

“…The nature of the biomaterial and the fabrication process are the major aspects that influence the scaffold properties . Over the years, different materials (such as metals, ceramics, glass, synthetic and natural polymers) have been used to produce scaffold . Biodegradable polymers including poly(glycolic acid) (PGA), poly(lactic acid) (PLA), poly[lactic‐co‐(glycolic acid)] (PLGA), polyethylene glicol, chitosan, collagen, hyaluronic acid, and alginate have been widely used in the tissue engineering of cartilage, bone, skin, ligament, and so forth.…”

Section: Introductionmentioning

confidence: 99%

“…8 Over the years, different materials (such as metals, ceramics, glass, synthetic and natural polymers) have been used to produce scaffold. 9,10 Biodegradable polymers including poly(glycolic acid) (PGA), poly(lactic acid) (PLA), poly[lactic-co-(glycolic acid)] (PLGA), polyethylene glicol, chitosan, collagen, hyaluronic acid, and alginate have been widely used in the tissue engineering of cartilage, 11 bone, 12 skin, 13 ligament, and so forth. In order to produce the porous structure, the most common foaming techniques are based on salt leaching, gas foaming, phase separation, freeze-drying, electrospinning techniques.…”

Section: Introductionmentioning

confidence: 99%

Cellulose‐based porous scaffold for bone tissue engineering applications: Assessment of hMSC proliferation and differentiation

Demitri

Raucci

Giuri

et al. 2015

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

Physical foaming combined with microwave-induced curing was used in this study to develop an innovative device for bone tissue regeneration. In the first step of the process, a stable physical foaming was induced using a surfactant (i.e. pluronic) as blowing agent of a homogeneous blend of Sodium salt of carboxymethylcellulose (CMCNa) and polyethylene glycol diacrylate (PEGDA700) solution. In the second step, the porous structure of the scaffold was chemically stabilized by radical polymerization induced by a homogeneous rapid heating of the sample in a microwave reactor. In this step 2,2-Azobis[2-(2-imidazolin-2 yl)propane]Dihydrochloride was used as thermoinitiator (TI). CMCNa and PEGDA were mixed with different blends to correlate the properties of final product with the composition. The chemical properties of each sample were evaluated by spectroscopy analysis ATR-IR (before and after curing) in order to maximize reaction yield, and optimize kinetic parameters (i.e. time curing, microwave power). The stability of the materials was evaluated in vitro by degradation test in Phosphate Buffered Saline. Biological analyses were performed to evaluate the effect of scaffold materials on cellular behavior in terms of proliferation and early osteogenic differentiation of human Mesenchymal Stem Cells. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 726-733, 2016.

show abstract

Development of Semi- and Grafted Interpenetrating Polymer Networks Based on Poly(Ethylene Glycol) Diacrylate and Collagen

Cited by 13 publications

References 31 publications

Gelatin/nano‐hydroxyapatite hydrogel scaffold prepared by sol‐gel technology as filler to repair bone defects

Gelatin/nano‐hydroxyapatite hydrogel scaffold prepared by sol‐gel technology as filler to repair bone defects

Spatially and temporally controlled hydrogels for tissue engineering

Cellulose‐based porous scaffold for bone tissue engineering applications: Assessment of hMSC proliferation and differentiation

Contact Info

Product

Resources

About