Development of Retinal Ganglion Cell Structure and Function

Sernagor, Evelyne; Eglen, Stephen J.; Wong, Rachel

doi:10.1016/s1350-9462(00)00024-0

Cited by 181 publications

(195 citation statements)

References 198 publications

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“…During early development, RGCs first establish synapses with amacrine cells, and later with bipolar cells (Sernagor et al, 2001). Before the retina becomes light sensitive, the starburst amacrine network mediates spontaneous retinal waves through the excitatory neurotransmitter, acetylcholine (Feller et al, 1996;Zheng et al, 2004).…”

Section: How Could Visual-evoked Activity and Bdnf Signaling Regulatementioning

confidence: 99%

“…In retina, the distinctive laminar patterns of retinal ganglion cell (RGC) dendrites govern the responsiveness of RGCs to visual stimulation (Sernagor et al, 2001). ON RGCs, which respond to light increment, have monolaminated dendritic arbors in the inner region (sublamina b) of the inner plexiform layer (IPL), where they receive exclusive excitatory synaptic inputs from ON bipolar cells (Famiglietti and Kolb, 1976;Nelson et al, 1978).…”

Section: Introductionmentioning

confidence: 99%

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Brain-Derived Neurotrophic Factor and TrkB Modulate Visual Experience-Dependent Refinement of Neuronal Pathways in Retina

et al. 2007

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Sensory experience refines neuronal structure and functionality. The visual system has proved to be a productive model system to study this plasticity. In the neonatal retina, the dendritic arbors of a large proportion of ganglion cells are diffuse in the inner plexiform layer. With maturation, many of these arbors become monolaminated. Visual deprivation suppresses this remodeling. Little is known of the molecular mechanisms controlling maturational and experience-dependent refinement. Here, we tested the hypothesis that brainderived neurotrophic factor (BDNF), which is known to regulate dendritic branching and synaptic function in the brain, modulates the developmental and visual experience-dependent refinement of retinal ganglion cells. We used a transgenic mouse line, in which a small number of ganglion cells were labeled with yellow fluorescence protein, to delineate their dendritic structure in vivo. We found that transgenic overexpression of BDNF accelerated the laminar refinement of ganglion cell dendrites, whereas decreased TrkB expression or retina-specific deletion of TrkB, the cognate receptor for BDNF, retarded it. BDNF-TrkB signaling regulated the maturational formation of new branches in ON but not the bilaminated ON-OFF ganglion cells. Furthermore, BDNF overexpression overrides the requirement for visual inputs to stimulate laminar refinement and dendritic branching of ganglion cells. These experiments reveal a previously unrecognized action of BDNF and TrkB in controlling cell-specific, experience-dependent remodeling of neuronal structures in the visual system.

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Section: How Could Visual-evoked Activity and Bdnf Signaling Regulatementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor and TrkB Modulate Visual Experience-Dependent Refinement of Neuronal Pathways in Retina

et al. 2007

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“…Chemical synaptic transmission, gap junctions, and extracellular diffusion of modulators such as adenosine or perhaps potassium work in concert to generate propagating activity in the retina (for review, see Wong, 1999;Sernagor et al, 2001;Zhou, 2001). This activity is initially mediated by cholinergic circuits and then by glutamatergic circuits (Wong, 1999;Zhou and Zhao, 1999;Bansal et al, 2000;Zhou and Zhao, 2000).…”

Section: Nachr-mediated Retinal Wavesmentioning

confidence: 99%

“…There is compelling evidence that spontaneous retinal activity influences RGC dendritic size and complexity (for review, see Sernagor et al, 2001). Blocking retinal activity in turtle retina with intraocular injections of the general nAChR antagonist d-tubocurarine significantly decreased the size of RGC dendritic fields (Sernagor and Grzywacz, 1996).…”

Section: Role Of Nachr-mediated Waves In Retina Developmentmentioning

confidence: 99%

The role of nAChR‐mediated spontaneous retinal activity in visual system development

Feller

2002

J. Neurobiol.

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ABSTRACT:In the developing vertebrate retina, nAChR synapses are among the first to appear. This early cholinergic circuitry plays a key role in generating "retinal waves," spontaneously generated waves of action potentials that sweep across the ganglion cell layer. These retinal waves exist for a short period of time during development when several circuits within the visual system are being established. Here I review the cholinergic circuitry of the developing retina and the role these early circuits play in the development of the retina itself and of retinal projections to the lateral geniculate nucleus of the thalamus.

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“…Other studies of the development of receptive field properties of RGCs in kittens, rabbits, and turtles have indicated that excitatory centers and inhibitory surrounds of some RGCs are still immature and larger at eye opening (Hamasaki and Sutija 1979;Masland 1977;Rusoff and Dubin 1977;Sernagor et al 2001;Sernagor and Grzywacz 1995), although a significant percentage of young RGCs had adult-like responses in both the cat and rabbit (Masland 1977;Tootle 1993).…”

mentioning

confidence: 99%

Receptive field center size decreases and firing properties mature in ON and OFF retinal ganglion cells after eye opening in the mouse

Koehler¹,

Akimov²,

Renterı́a

2011

Journal of Neurophysiology

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Development of Retinal Ganglion Cell Structure and Function

Cited by 181 publications

References 198 publications

Brain-Derived Neurotrophic Factor and TrkB Modulate Visual Experience-Dependent Refinement of Neuronal Pathways in Retina

Brain-Derived Neurotrophic Factor and TrkB Modulate Visual Experience-Dependent Refinement of Neuronal Pathways in Retina

The role of nAChR‐mediated spontaneous retinal activity in visual system development

Receptive field center size decreases and firing properties mature in ON and OFF retinal ganglion cells after eye opening in the mouse

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