Development of Rapid SPECT Acquisition Protocol for Myocardial Perfusion Imaging

Vija, A. Hans; Zeintl, J.; Chapman, James T.; Hawman, Eric G.; Hornegger, Joachim

doi:10.1109/nssmic.2006.354246

Cited by 11 publications

(9 citation statements)

References 10 publications

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“…For conventional SPECT, the detectors were placed close to the patient in a body-contour mode, whereas for IQÁSPECT, rotation of the detectors was circular with a 28-cm radius and centered on the heart (12). SPECT images are routinely reconstructed with 3-dimensional iterative algorithms (22) and with an additional correction for the geometry of the astigmatic collimator for IQÁSPECT (23,24).…”

Section: G-cameras and Collimation Systemsmentioning

confidence: 99%

Compared Performance of High-Sensitivity Cameras Dedicated to Myocardial Perfusion SPECT: A Comprehensive Analysis of Phantom and Human Images

et al. 2012

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Differences in the performance of cadmium-zinc-telluride (CZT) cameras or collimation systems that have recently been commercialized for myocardial SPECT remain unclear. In the present study, the performance of 3 of these systems was compared by a comprehensive analysis of phantom and human SPECT images. Methods: We evaluated the Discovery NM 530c and DSPECT CZT cameras, as well as the Symbia Anger camera equipped with an astigmatic (IQÁSPECT) or parallel-hole (conventional SPECT) collimator. Physical performance was compared on reconstructed SPECT images from a phantom and from comparable groups of healthy subjects. Results: Classifications were as follows, in order of performance. For count sensitivity on cardiac phantom images (countsÁs 21 ÁMBq 21 ), DSPECT had a sensitivity of 850; Discovery NM 530c, 460; IQÁSPECT, 390; and conventional SPECT, 130. This classification was similar to that of myocardial counts normalized to injected activities from human images (respective mean values, in countsÁs 21 ÁMBq 21 : 11.4 6 2.6, 5.6 6 1.4, 2.7 6 0.7, and 0.6 6 0.1). For central spatial resolution: Discovery NM 530c was 6.7 mm; DSPECT, 8.6 mm; IQÁSPECT, 15.0 mm; and conventional SPECT, 15.3 mm, also in accordance with the analysis of the sharpness of myocardial contours on human images (in cm 21 : 1.02 6 0.17, 0.92 6 0.11, 0.64 6 0.12, and 0.65 6 0.06, respectively). For contrast-to-noise ratio on the phantom: Discovery NM 530c had a ratio of 4.6; DSPECT, 4.1; IQÁSPECT, 3.9; and conventional SPECT, 3.5, similar to ratios documented on human images (5.2 6 1.0, 4.5 6 0.5, 3.9 6 0.6, and 3.4 6 0.3, respectively). Conclusion: The performance of CZT cameras is dramatically higher than that of Anger cameras, even for human SPECT images. However, CZT cameras differ in that spatial resolution and contrast-to-noise ratio are better with the Discovery NM 530c, whereas count sensitivity is markedly higher with the DSPECT.Key Words: CZT-cameras; high-speed SPECT; myocardial perfusion imaging; count sensitivity St ress myocardial SPECT has been markedly enhanced by the recent commercialization of cameras with semiconductor (cadmium-zinc-telluride [CZT]) detectors or new collimation systems. These improved systems enhance the sensitivity of count detection and thereby enable recording times or tracer doses to be reduced, a property that has highly favorable consequences on patient comfort and radiation exposure (1-4). This enhancement is based mainly on acquisitions that are heart-centric but obtained with very different technologies: first, for the IQÁSPECT system (Siemens Medical Solutions (5-8)), an Anger camera equipped with collimators convergent on the image center (astigmatic collimators); second, for the DSPECT system (Spectrum Dynamics (9-13)), mobile columns of CZT detectors with wide parallel-hole collimators; and third, for the Discovery NM 530c system (GE Healthcare (14-21)), fixed CZT detectors with multipinhole collimators.The respective performance of these new cameras and collimation systems has been analyzed, but ...

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Section: G-cameras and Collimation Systemsmentioning

confidence: 99%

Compared Performance of High-Sensitivity Cameras Dedicated to Myocardial Perfusion SPECT: A Comprehensive Analysis of Phantom and Human Images

et al. 2012

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“…However, using this data for generating multiple count reduced derivatives by angular extraction and binomial subsampling seems to be an adequate and simple approach for creating a population of data sets. In addition, the processing tool dedicated for real data sets in DICOM-format provides capabilities for use in clinical research applied to patient data in retrospective studies [15].…”

Section: Discussionmentioning

confidence: 99%

Quantifying the Effects of Acquisition Parameters in Cardiac SPECT Imaging and Comparison with Visual Observers

Zeintl¹,

Vija²,

Chapman³

et al. 2006

2006 IEEE Nuclear Science Symposium Conference Record

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Abstract-Significant debate remains whether the established imaging protocols for myocardial perfusion SPECT delivers optimal image quality. This debate has been intensified with the introduction of advanced iterative reconstruction techniques which differ considerably from the FBP reconstruction technology commonly available when the current protocols were established. In order to characterize and classify image quality affecting factors, simulations combined with time consuming observer studies are often used.In this work we seek to simplify these image assessment tasks by performing numerical characterizations based on real data, and try to unite quantitative performance with visual impression derived from human observer studies.For this purpose, we assess the response of cardiac image quality to variations in acquisition and reconstruction protocol. We analyze anthropomorphic phantom data derived from large dimensioned acquisitions via subsampling in terms of counts and spatial and angular resolution. Data is reconstructed using FBP and OSEM-3D ("Flash3D") with parameter variations and the reconstructed volumes are quantitatively analyzed for cardiac relevant features like myocardial uniformity and resolution. Receiver Operating Characteristic (ROC) studies are performed for selected imaging parameters. Results obtained characterize the sensitivity of the cardiac image quality to some changes in the imaging protocol like angular step, orbit radius and collimation and show correlations of key quantitative measures and related ROC behavior.

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“…50 SPECT cardiac acquisition protocols (CardioFlash) have been developed utilizing Flash3D, where the acquisition time can be reduced to between 33% and 50%, as compared to the standard acquisition protocols with FBP reconstruction. An example of the image quality obtained with CardioFlash is shown in phantoms ( Figure 19) and in clinical images (Figure 20).…”

Section: Siemens Flash 3dmentioning

confidence: 99%

Advances in technical aspects of myocardial perfusion SPECT imaging

Slomka

Patton

Berman

et al. 2009

Journal of Nuclear Cardiology

226

137

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Although myocardial perfusion SPECT (MPS) imaging is widely used in current clinical practice, it suffers from some fundamental limitations including long image acquisition, low image resolution, and patient radiation dose. In the last two decades, MPS was performed most commonly by standard dual-head scintillation cameras with parallel-hole collimators, typically configured in a 90°detector geometry and image reconstruction based on standard filtered-back projection algorithms. The required scan times were as along as 15-20 minutes for each stress and rest MPS acquisition to provide adequate imaging statistics, resulting in long overall test times and frequent artifacts caused by patient motion during the scan as well as compromised patient comfort. Recently, it has become very important to address these limitations, since MPS has new competitors in the non-invasive imaging arena most notably coronary CT angiography (CCTA), which allow diagnostic imaging in a very short time. In addition, a practice of combining MPS with other modalities such as CCTA for better diagnostic certainty 1 has intensified concerns regarding total radiation dose delivered to the patient. 2 The radiation dose and acquisition time are intrinsically linked with each other, as longer acquisition times could be used with lower injected doses and higher doses could be used to shorten acquisition times.There have been significant recent efforts by industry and academia to develop new imaging systems with increased sensitivity and new methods of image reconstruction optimizing image quality, which will simultaneously allow higher photon sensitivity and improve both image quality and resolution. These efforts address the main limitations of MPS by combining several approaches such as changing the detector geometry and optimizing tomographic sampling of the field of view for myocardial imaging, improving the detector material and collimator design, and optimizing the image reconstruction algorithms. In this review article we summarize these developments. NEW HARDWARE FOR OPTIMIZED MPS IMAGINGSeveral new dedicated hardware camera systems with optimized acquisition geometry, collimator design, and associated reconstruction software have been recently introduced by various vendors. Innovative designs of the gantry and detectors have been proposed which allow increased sampling of the myocardial region, and thus allow better local sensitivity. These systems combine an improvement in spatial resolution and sensitivity. By faster imaging times due to increased sensitivity and by eliminating the need to position the patient's arms above the head by imaging in an upright or reclining position, patient comfort is dramatically improved. As a consequence of faster imaging times and more comfortable patient positioning, these systems have the additional benefit of reducing patient motion during a scan. Furthermore, claustrophobic effects are reduced and the floor space requirements are more flexible since the new detectors and the associated mechanical are ...

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Development of Rapid SPECT Acquisition Protocol for Myocardial Perfusion Imaging

Cited by 11 publications

References 10 publications

Compared Performance of High-Sensitivity Cameras Dedicated to Myocardial Perfusion SPECT: A Comprehensive Analysis of Phantom and Human Images

Compared Performance of High-Sensitivity Cameras Dedicated to Myocardial Perfusion SPECT: A Comprehensive Analysis of Phantom and Human Images

Quantifying the Effects of Acquisition Parameters in Cardiac SPECT Imaging and Comparison with Visual Observers

Advances in technical aspects of myocardial perfusion SPECT imaging

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