Development of radiation therapy for breast cancer

Salim, Nidal; Shonus, D. Kh.; Stolbovoy, Alexandr

doi:10.17116/onkolog20176459-65

Onkol. Z. im. P.A. Gercena

2017

DOI: 10.17116/onkolog20176459-65

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Development of radiation therapy for breast cancer

Nidal Salim¹,

D. Kh. Shonus²,

Alexandr Stolbovoy³

Abstract: Тему лучевого лечения рака молочной железы (РМЖ) не перестают обсуждать на научных съездах и страницах онкологических журналов. Это понятно, ведь облучение, как и хирургическая операция, высокоэффективная и до сих пор неотъемлемая часть противоракового лечения. Лечение ионизирующим излучением в различных вариантах используется при РМЖ от нулевой (TisN0M0) до IV стадии. Лечение РМЖ имеет более чем вековую историю. С него началось использование ионизирующего излучения в лечебных целях. Первый сеанс лечения РМЖ п… Show more

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Cited by 3 publications

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Features of combined treatment for breast cancer with isolated supraclavicular or parasternal lymph node metastasis

Zikiryakhodzhaev¹,

Рассказова²,

Ермощенкова³

et al. 2019

Onkol. Z. im. P.A. Gercena

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Проведен анализ современных подходов к диагностике и лечению рака молочной железы (РМЖ) с метастазами в надключичных и парастернальных лимфатических узлах (ЛУ). Рассмотрены особенности метастазирования РМЖ, указано, что из надключичных ЛУ выделяют анатомически наиболее важный сигнальный, или сторожевой, узел. Отмечено, что при локализации опухоли в медиальных и центральных квадрантах железы возрастает роль парастернального пути, поскольку внутренний грудной коллектор является одним из основных путей метастазирования РМЖ. Рассмотрена роль лучевой терапии в качестве одного из методов локального воздействия на пoраженный метастазами коллектор. Приведены результаты проведенных к настоящему времени клинических исследований по оценке эффективности и безопасности лечения РМЖ с метастазами в надключичных и парастернальных ЛУ. Отмечено, что для таких больных характерен высокий риск недиагностированных отдаленных метастазов даже в отсутствие явных клинических признаков их наличия. Этим пациенткам рекомендуют назначать комбинированное лечение (химиотерапия, хирургическое лечение и лучевая терапия). В то же время убедительные данные, подтверждающие целесообразность назначения комбинированного лечения рассматриваемой категории больных РМЖ, на сегодняшний день отсутствуют, а роль хирургического лечения при метастазах в надключичных ЛУ на сегодняшний день исследована недостаточно. Тем не менее установлено, что лимфаденэктомия надключичной группы является предиктором общей выживаемости данного контингента пациенток. Ряд авторов полагают, что с учетом этого РМЖ с метастазами в надключичных и парастернальных ЛУ без признаков отдаленного метастазирования можно рассматривать как регионарный и, следовательно, потенциально излечимый. Ключевые слова: рак молочной железы, местно-распространенный рак молочной железы, метастазы в парастернальных лимфатических узлах, лучевая терапия, первично-множественный метахронный рак молочных желез, комплексное лечение.

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Features of combined treatment for breast cancer with isolated supraclavicular or parasternal lymph node metastasis

Zikiryakhodzhaev¹,

Рассказова²,

Ермощенкова³

et al. 2019

Onkol. Z. im. P.A. Gercena

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Combined modality treatment of early breast cancer. Literature review

Akhmetzyanov,

Akhmetzyanova,

Ankhimova

et al. 2024

Sib. onkol. ž.

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The object of the study was to conduct a systematic literature review on combined modality treatment for early-stage breast cancer using postoperative and intraoperative radiation therapy, and consider new treatment approaches for early breast cancer.Material and Methods. The search for sources relevant to the review topic was carried out in the Medline, Cochrane Library, and Elibrary systems. A total of 905 studies on combination treatments for early breast cancer were identified, of which 43 were included in the review.Results. Data analysis showed that the rate of local relapses in early breast cancer was lower in patients who underwent breast-conserving surgery in combination with adjuvant radiation therapy than in patients without adjuvant radiation therapy. Research is ongoing on radiotherapy deintensification using intraoperative radiation therapy for patients at low risk of recurrence. Ongoing clinical trials support the omission of radiotherapy after breast-conserving surgery for elderly women with hormone receptor-positive early-stage breast cancer, who receive adjuvant endocrine therapy. Understanding the characteristics of the tumor process will allow us to personalize the treatment of patients with early breast cancer, reduce the risk of local relapses, and avoid unnecessary treatment-related complications.Conclusion. To improve survival in breast cancer patients is only possible by maximizing the tumor control. The effectiveness of adjuvant radiation therapy, which is an integral component in the combined modality treatment of early breast cancer, has been proven. However, third-generation studies discuss the feasibility of identifying a low-risk group of patients with a favorable clinical prognosis, who receive adequate endocrine therapy, and additional radiation do not provide a significant survival benefit.

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Skin and Subcutaneous Adipose Tissue Damage After Radiation Therapy in Breast Cancer Patients

Bazyka¹,

Litvinenko²,

Bugaytsov³

et al. 2021

Probl Radiac Med Radiobiol

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The analysis of long-term researches of the pathological changes arising in soft tissues at patients with a breast cancer as a result of radical surgical treatment and adjuvant radiotherapy is carried out in work. The article shows that the standard approach to postoperative radiation therapy, which is based only on the prevalence of the primary tumor process is not always justified. Very often it leads to excessive radiation load on the patient's body and the development of local acute and chronic radiation reactions of the skin, subcutaneous tissue and other soft tissues. In this regard, the question of differentiated purpose of radiotherapy acquires special value first of all at patients with small primary prevalence of tumor process. The paper presents the results of studies to study changes in the anterior chest wall in patients with breast cancer. In relation to the conduct of adjuvant radiotherapy more often need to use the concept of personalized radiation therapy. Radical operation, post-radiation early and late pathological changes in soft tissues, disturbance of microcirculation of lymph and blood, disturbance of innervation of vessels of an upper extremity, peripheral nerves in system of a cervical and plexus plexus, leads to intensive degenerative and dystrophic changes in soft tissues of the upper. and causes morphological changes in them and further progression of reflex neurovascular and neurodystrophic disorders. Based on the data of adverse effects of radiotherapy on the skin and surrounding tissues, as well as to reduce excessive radiation exposure to the patient's body, a differentiated approach to the appointment of adjuvant radiation therapy. The Scientific Council meeting of NAMS approved the NRCRM Annual Report. Key words: breast cancer, radiation therapy, adjuvant radiation therapy, complications of radiation therapy, radiation reactions, radiation injuries.

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Development of radiation therapy for breast cancer

Cited by 3 publications

References 59 publications

Features of combined treatment for breast cancer with isolated supraclavicular or parasternal lymph node metastasis

Features of combined treatment for breast cancer with isolated supraclavicular or parasternal lymph node metastasis

Combined modality treatment of early breast cancer. Literature review

Skin and Subcutaneous Adipose Tissue Damage After Radiation Therapy in Breast Cancer Patients

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