Development of quantitative neuropsychological tests for diagnosis of subclinical hepatic encephalopathy in liver cirrhosis patients and establishment of diagnostic criteria?multicenter collaborative study in Japanese

Kato, Akinobu; Kato, Masaaki; Ishii, Hiromasa; Ichimiya, Yosuke; Suzuki, Kazuyuki; Kawasaki, Hironaka; Yamamoto, Shin; Kumashiro, Ryukichi; Yamamoto, Kyosuke; Kawamura, Naohiro; Hayashi, Naoaki; Matsuzaki, Shinya; Terano, Akira; Okita, Kiwamu; Watanabe, Akïharu

doi:10.1016/j.hepres.2004.07.001

Cited by 32 publications

(42 citation statements)

References 16 publications

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“…None of the subjects in the present study had overt hepatic encephalopathy. On the other hand, screening for minimal hepatic encephalopathy (MHE) by psychometric tests or electro‐physical examinations has not been done, 19–24 so it is not known whether some of the subjects in the present study had MHE. A considerable percentage of patients with CH are reported to have MHE 25–28 .…”

Section: Discussionmentioning

confidence: 95%

Amino acid imbalance in patients with chronic liver diseases

Michitaka

Hiraoka

Kume

et al. 2010

Hepatology Research

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Section: Discussionmentioning

confidence: 95%

Amino acid imbalance in patients with chronic liver diseases

Michitaka

Hiraoka

Kume

et al. 2010

Hepatology Research

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“…Multiple versions of the test battery are available to prevent the learning effect of repeated testing. There is no gender effect and the test predicts overt HE and death (Montagnese et al 2011;Kato et al 2004). …”

Section: Methodsmentioning

confidence: 99%

Minimal hepatic encephalopathy characterized by parallel use of the continuous reaction time and portosystemic encephalopathy tests

2015

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Minimal hepatic encephalopathy (MHE) is a frequent complication to liver cirrhosis that causes poor quality of life, a great burden to caregivers, and can be treated. For diagnosis and grading the international guidelines recommend the use of psychometric tests of different modalities (computer based vs. paper and pencil). To compare results of the Continuous Reaction time (CRT) and the Portosystemic Encephalopathy (PSE) tests in a large unselected cohort of cirrhosis patients without clinically detectable brain impairment and to clinically characterize the patients according to their test results. The CRT method is a 10-minute computerized test of a patient's motor reaction time stability (CRTindex) to 150 auditory stimuli. The PSE test is a 20-minute paper-pencil test evaluating psychomotor speed. Both tests were performed at the same occasion in 129 patients. Both tests were normal in only 36% (n = 46) of the patients and this group had the best quality of life, a normal CRP, a low risk of subsequent overt HE, and a low short term mortality. Either the CRT or the PSE test was abnormal in a total of 64% of the patients (n = 83), the CRT in 53% (n = 69) and the PSE in 34% (n = 44). All these patients had a poorer quality of life, low-grade CRP elevation, moderate risk for subsequent overt HE, and a higher than 20% short term mortality. Both tests were abnormal in 23% (n = 30) of the patients and this group had more advanced cirrhosis and a 40 % short-term mortality. One of the tests was abnormal in the majority of the patients but concordant in only 60%. Most cirrhosis patients seem to have impairments of different cognitive domains and more domains with advancing disease. Two abnormal tests identified patients with an increased risk of overt HE and death.

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“…The brain show evidence of metabolic disorder in cirrhotic patients with no overt hepatic encephalopathy . Covert hepatic encephalopathy (CHE) is a neurocognitive complication of chronic liver disease and is considered the mildest form of the clinical spectrum of hepatic encephalopathy . Recently, we reported that CHE is seen in approximately 30% of cirrhotic patients in Japan .…”

Section: Introductionmentioning

confidence: 99%