Amino acid imbalance in patients with chronic liver diseases

Michitaka, Kojiro; Hiraoka, Atsushi; Kume, Misaki; Uehara, Takeki; Hidaka, Shigekazu; Nakamura, Tomoyuki; Hasebe, Aki; Miyamoto, Yoshinori; Ichiryu, Misa; Tanihira, Tetsuya; Nakahara, Hiromasa; Ochi, Hironori; Tanabe, Atsushi; Uesugi, Kentaro; Terada, Yoshio; Mashiba, Toshie; Abe, Masanori; Hiasa, Yoichi; Matsuura, Bunzo; Onji, Morikazu

doi:10.1111/j.1872-034x.2009.00614.x

Cited by 46 publications

(35 citation statements)

References 43 publications

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“…Diff erential transcriptional regulation of phenylalanine hydroxylase has also been recently reported in a cohort of chronic HCV-infected transplant patients ( 31 ). Although elevation of plasma tyrosine has been commonly identifi ed across all stages of CHC-induced fi brosis (F1-F4), lower branched chain amino acid levels are less consistently observed and may be signifi cantly depleted in F4-graded (cirrhotic) patients only ( 32,33 ).…”

Section: Discussionmentioning

confidence: 95%

Metabolic Phenotyping for Enhanced Mechanistic Stratification of Chronic Hepatitis C-Induced Liver Fibrosis

Sands

Guha

Kyriakides

et al. 2015

American Journal of Gastroenterology

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Our findings suggest that modeling against a continuous ELF-derived score of fibrosis provides a more robust assessment of the metabolic changes associated with fibrosis than modeling against the categorical METAVIR score. Plasma metabolic phenotypes reflective of CHC-induced fibrosis primarily define alterations in amino-acid and lipid metabolism, and hence identify mechanistically relevant pathways for further investigation as therapeutic targets.

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Section: Discussionmentioning

confidence: 95%

Metabolic Phenotyping for Enhanced Mechanistic Stratification of Chronic Hepatitis C-Induced Liver Fibrosis

Sands

Guha

Kyriakides

et al. 2015

American Journal of Gastroenterology

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“…One of the main reasons for this was not only a reduction in hepatocytes but also an increase in inflammatory cytokines, such as interleukin-6 and tumor necrosis factor alpha. The proportion of amino acids in liver cirrhosis is changed, such as a lower branched-chain amino acid to tyrosine ratio 17. Leucine stimulated the growth of hepatocytes and induced release of hepatic growth factor from stellate cells, perhaps in advanced liver injury, and reduction of leucine caused insufficient recovery from liver damage following the delayed recovery of serum albumin 18…”

Section: Discussionmentioning

confidence: 99%

Factors influencing distant recurrence of hepatocellular carcinoma following combined radiofrequency ablation and transarterial chemoembolization therapy in patients with hepatitis C

Nojiri

Kusakabe²,

Shinkai³

et al. 2011

CMR

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Background:The purpose of this study was to clarify important risk factors for distant recurrence of hepatocellular carcinoma in patients positive for hepatitis C and without local recurrence.Methods:A total of 212 patients (145 males and 67 females) underwent radiofrequency ablation and transcatheter arterial embolization or transcatheter arterial chemoembolization at initial development of hepatocellular carcinoma. All patients were positive for hepatitis C. Child–Pugh classification was A in 115 and B in 97. The indication for radiofrequency ablation was the presence of up to three tumors ≤ 3 cm. The distant recurrence rate was analyzed using the Kaplan–Meier method and tested by Wilcoxon’s method.Results:Cumulative distant recurrence rates at years 1, 3, and 5 were 19%, 62%, and 79%, respectively. On univariate analysis, a ≥ 3 cm tumor, ≥ 50 ng/mL α-fetoprotein level, and < 3.6 g/dL serum albumin level were significant risk factors for distant recurrence, but only a serum albumin level < 3.6 g/dL (P = 0.004) was identified as significant on multivariate analysis. In the group with a pretreatment albumin level ≥ 3.6 g/dL, the distant recurrence rate was compared between patients in whom the albumin level rose, remained unchanged, or decreased by < 0.3 g/dL, and those in whom the level decreased by ≥ 0.3 g/dL. The rate was significantly higher in the latter, with a one-year recurrence rate of 7% versus 15% (P = 0.04).Conclusion:Distant recurrence was significantly decreased in patients with a high serum albumin level. Distant recurrence was more likely to occur in patients with a decreased albumin level, although the pretreatment level was high. Thus, strict follow-up after treatment for hepatocellular carcinoma is necessary in patients with low serum albumin levels.

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“…A recent study investigated plasma amino acid imbalances in relation to the progression of liver fibrosis [20].…”

Section: Amino Acid Imbalances In Liver Diseasesmentioning

confidence: 99%

Plasma amino acid imbalance: dangerous in chronic diseases?

Roth

Druml²

2011

Current Opinion in Clinical Nutrition and Metabolic Care

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Recent investigations revealed that amino acids are powerful molecules in mediating cell signalling. Therefore, it can be hypothesized that the severe amino acid imbalances as observed in uraemia or liver failure may exert a relevant impact on various physiologic processes and on organ function. The recent results described in Drosophila should stimulate a new research area on the effect of amino acid supply in various disease processes.

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Amino acid imbalance in patients with chronic liver diseases

Abstract: A considerable number of patients not only with LC but also with CH showed lower levels of BTR. It has been clarified that amino acid imbalance of Tyr was found in the early stage of liver disease, whereas decrease of BCAA was found mainly in F4 stage.

Cited by 46 publications

References 43 publications

Metabolic Phenotyping for Enhanced Mechanistic Stratification of Chronic Hepatitis C-Induced Liver Fibrosis

Metabolic Phenotyping for Enhanced Mechanistic Stratification of Chronic Hepatitis C-Induced Liver Fibrosis

Factors influencing distant recurrence of hepatocellular carcinoma following combined radiofrequency ablation and transarterial chemoembolization therapy in patients with hepatitis C

Plasma amino acid imbalance: dangerous in chronic diseases?

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