Development of Polymer-Based Nanoformulations for Glioblastoma Brain Cancer Therapy and Diagnosis: An Update

Rabha, Bijuli; Bharadwaj, Kaushik Kumar; Pati, Siddhartha; Choudhury, Bhabesh Kumar; Sarkar, Tanmay; Kari, Zulhisyam Abdul; Edinur, Hisham Atan; Baishya, Debabrat; Atanase, Leonard Ionuţ

doi:10.3390/polym13234114

Cited by 28 publications

(18 citation statements)

References 134 publications

(122 reference statements)

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“…Non-viral vectors, such as liposomes, polymers, and polypeptides, have been developed [ 6 , 7 , 8 ]. With the development of nanotechnology, nanocarriers including self-assembled nanoparticles, polymers, nanocapsules, and two-dimensional (2D) nanomaterials have been demonstrated to significantly improve siRNA transfection into solid cancer cells, such as human breast cancer cells [ 9 , 10 ], pancreatic cancer cells [ 11 ], prostate cancer cells [ 12 ], and brain cancer cells [ 13 ]. For solid tumors, although there are pathophysiological barriers, including vasculature or non-vasculature barriers, siRNA-based medicine has obvious advantages in terms of stability, drug loading efficiency, pharmacokinetics, targeting ability, safety, and multi-functionality [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel Form of Arginine-Chitosan as Nanoparticles Efficient for siRNA Delivery into Mouse Leukemia Cells

Luo

Chen

Liu

et al. 2023

IJMS

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The modification of chitosan (CS) has greatly expanded its application in the field of medicine. In this study, low-molecular-weight chitosan was modified with arginine (Arg) by a simple method. The identification by the Fourier transform infrared spectra (FTIR) showed that Arg was successfully covalently attached to the CS. Interestingly, Arg-CS was identified as nanoparticles by atomic force microscopy (AFM) and transmission electron microscopy (TEM), whose particle size was 75.76 ± 12.07 nm based on Dynamic Light Scattering (DLS) characterization. Then, whether the prepared Arg-CS nanoparticles could encapsulate and deliver siRNA safely was investigated. Arg-CS was found to be able to encapsulate siRNAs in vitro via electrostatic interaction with siRNA; the Arg-CS/siRNA complex was safe for L1210 leukemia cells. Therefore, modification of chitosan by Arg produces novel nanoparticles to deliver siRNA into leukemia cells. This is the first time to identify Arg-CS as nanoparticles and explore their ability to deliver Rhoa siRNA into T-cell acute lymphoblastic leukemia (T-ALL) cells to advance therapies targeting Rhoa in the future.

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Section: Introductionmentioning

confidence: 99%

A Novel Form of Arginine-Chitosan as Nanoparticles Efficient for siRNA Delivery into Mouse Leukemia Cells

Luo

Chen

Liu

et al. 2023

IJMS

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“…Cancer is a severe issue that threatens the health of all human communities (16), and natural products have played an important role in the history of anticancer medication development (17)(18)(19)(20). A large number of experiments in recent years have shown potent anti-cancer properties of several seaweed-derived compounds by inhibitions of tumor development, adhesion, invasion, and metastasis (10,21,22).…”

Section: Introductionmentioning

confidence: 99%

Potent Bioactive Compounds From Seaweed Waste to Combat Cancer Through Bioinformatics Investigation

Bharadwaj

Ahmad

Pati³

et al. 2022

Front. Nutr.

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The seaweed industries generate considerable amounts of waste that must be appropriately managed. This biomass from marine waste is a rich source of high-value bioactive compounds. Thus, this waste can be adequately utilized by recovering the compounds for therapeutic purposes. Histone deacetylases (HDACs) are key epigenetic regulators established as one of the most promising targets for cancer chemotherapy. In the present study, our objective is to find the HDAC 2 inhibitor. We performed top-down in silico methodologies to identify potential HDAC 2 inhibitors by screening compounds from edible seaweed waste. One hundred ninety-three (n = 193) compounds from edible seaweeds were initially screened and filtered with drug-likeness properties using SwissADME. After that, the filtered compounds were followed to further evaluate their binding potential with HDAC 2 protein by using Glide high throughput virtual screening (HTVS), standard precision (SP), extra precision (XP), and quantum polarized ligand docking (QPLD). One compound with higher negative binding energy was selected, and to validate the binding mode and stability of the complex, molecular dynamics (MD) simulations using Desmond were performed. The complex-binding free energy calculation was performed using molecular mechanics-generalized born surface area (MM-GBSA) calculation. Post-MD simulation analyses such as PCA, DCCM, and free energy landscape were also evaluated. The quantum mechanical and electronic properties of the potential bioactive compounds were assessed using the density functional theory (DFT) study. These findings support the use of marine resources like edible seaweed waste for cancer drug development by using its bioactive compounds. The obtained results encourage further in vitro and in vivo research. Our in silico findings show that the compound has a high binding affinity for the catalytic site of the HDAC 2 protein and has drug-likeness properties, and can be utilized in drug development against cancer.

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“…To investigate the theragnostic behavior of nanomaterials in glioblastoma, a few criteria are considered, which include magnificent optical features (i.e., fluorescence), BBB permeating capacity, adequate biocompatibility, and desirable physicochemical properties. Until now, abundant research has been devoted to theranostics against brain tumors by using a myriad of nanoscale materials [17][18][19][20][21][22][23]. In this regard, nanotechnology-based theranostics can provide a window of opportunities, such as maximum solubility, improved pharmacokinetics, and enhanced targeted therapeutic efficacy.…”

Section: Introductionmentioning

confidence: 99%

Modernistic and Emerging Developments of Nanotechnology in Glioblastoma-Targeted Theranostic Applications

Lakshmi

Kim

2022

IJMS

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Brain tumors such as glioblastoma are typically associated with an unstoppable cell proliferation with aggressive infiltration behavior and a shortened life span. Though treatment options such as chemotherapy and radiotherapy are available in combating glioblastoma, satisfactory therapeutics are still not available due to the high impermeability of the blood–brain barrier. To address these concerns, recently, multifarious theranostics based on nanotechnology have been developed, which can deal with diagnosis and therapy together. The multifunctional nanomaterials find a strategic path against glioblastoma by adjoining novel thermal and magnetic therapy approaches. Their convenient combination of specific features such as real-time tracking, in-depth tissue penetration, drug-loading capacity, and contrasting performance is of great demand in the clinical investigation of glioblastoma. The potential benefits of nanomaterials including specificity, surface tunability, biodegradability, non-toxicity, ligand functionalization, and near-infrared (NIR) and photoacoustic (PA) imaging are sufficient in developing effective theranostics. This review discusses the recent developments in nanotechnology toward the diagnosis, drug delivery, and therapy regarding glioblastoma.

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Development of Polymer-Based Nanoformulations for Glioblastoma Brain Cancer Therapy and Diagnosis: An Update

Cited by 28 publications

References 134 publications

A Novel Form of Arginine-Chitosan as Nanoparticles Efficient for siRNA Delivery into Mouse Leukemia Cells

A Novel Form of Arginine-Chitosan as Nanoparticles Efficient for siRNA Delivery into Mouse Leukemia Cells

Potent Bioactive Compounds From Seaweed Waste to Combat Cancer Through Bioinformatics Investigation

Modernistic and Emerging Developments of Nanotechnology in Glioblastoma-Targeted Theranostic Applications

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