Development of Poly(ethylene glycol) Based Amphiphilic Copolymers for Controlled Release Delivery of Carbofuran

Shakil, Najam A.; Singh, Mukesh; Pandey, Alka; Kumar, Jitendra; Pankaj,; Parmar, Virinder S.; Singh, Manish Kumar; Pandey, Ravi P.; Watterson, Arthur C.

doi:10.1080/10601320903527038

Cited by 59 publications

(25 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 General method of polymerization and O-alkylation (functionalisation) 1500)-oxy-5-hydroxyisophthaloyl] was established from their 1 H and 13 C NMR spectrum. Further, this polymer had been derivatized by attaching decanyl chain to phenolic hydroxyl group as reported by Shakil et al 2010. The resulting amphiphilic polymeric system (4), Poly[Poly(Oxyethylene-1500)-oxy-5-decanylisophthaloyl] were also characterized by 1 H and 13 C NMR spectra.…”

Section: Synthesis and Characterization Of Amphiphilic Copolymersmentioning

confidence: 99%

“…The monomers, dimethyl 5-hydroxyisophthalate (0.21 g) (1) and PEG-1500 (1.5 g) (2) were taken in equimolar quantities in two necked round bottom flask and kept on silicon oil bath at 80-90°C (Shakil et al 2010). The reaction was performed under vacuum with constant stirring.…”

Section: Synthesis Of Amphiphilic Copolymersmentioning

confidence: 99%

“…General method of coupling of bromodecane with poly[poly(oxyethylene-1500)-Oxy-5-hydroxyisophthaloyl] (4) Equimolar quantities of polymers (3) (1.7 g) and bromodecane (0.24 g) were dissolved in dry acetone (10 ml) and to the resultant solution was added equimolar amount of anhydrous potassium carbonate (0.13 g) (Shakil et al 2010). The reaction mixture was refluxed at 60-70°C and progress of the reaction was monitored by TLC using ethyl acetate in petroleum ether (30 %).…”

Section: Synthesis Of Amphiphilic Copolymersmentioning

confidence: 99%

“…The mobile phase was kept at such a rate that the active ingredient and polymer do not appear very close in the HPLC chromatogram, i.e., Methanol:TBME (70:30 v/v). The literature procedure was followed in both experiments (Shakil et al 2010). …”

Section: Encapsulation Efficiencymentioning

confidence: 99%

“…Copolymers derived from PEGs and diester and their use in drug delivery systems to encapsulate both hydrophilic and hydrophobic drugs have been reported in literature (Kumar et al 2002 andKumar et al 2004;Shakil et al 2010;Loha et al 2011;Kaushik et al 2013). This approach is based on the formation of nano-micelles by the self-assembly of amphiphilic copolymers in aqueous media (Shakil et al 2010).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Development of slow release formulations of β-carotene employing amphiphilic polymers and their release kinetics study in water and different pH conditions

et al. 2015

Self Cite

View full text Add to dashboard Cite

β-carotene, a potent antioxidant, has been encapsulated and slow release (SR) formulations were prepared using laboratory synthesized poly(ethylene glycols) (PEGs) based functionalized amphiphilic copolymers. Encapsulation efficiency and loading capacity of the developed formulations were determined which ranged from 22.60 to 28.08 % and 2.2 to 2.8 % respectively. The release kinetics of β-carotene from developed formulations in water revealed increased solubility and prolonged stability of β-carotene. The formulations were further subjected to different pH conditions (viz., 1.8, 6.8 and 7.8) corresponding to human gastrointestinal tract to study the effect of pH on the release of β-carotene. The diffusion exponent (n values) ranged from the 0.1540 to 0.2342 for developed formulation. The results showed that developed slow release formulations were unaffected by the highly acidic conditions referring to the gastric environment of human body. However, the release of β-carotene was high at pH 7.8 and slightly higher at pH 6.8.

show abstract

Section: Synthesis and Characterization Of Amphiphilic Copolymersmentioning

confidence: 99%

Section: Synthesis Of Amphiphilic Copolymersmentioning

confidence: 99%

Section: Synthesis Of Amphiphilic Copolymersmentioning

confidence: 99%

Section: Encapsulation Efficiencymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Development of slow release formulations of β-carotene employing amphiphilic polymers and their release kinetics study in water and different pH conditions

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

Novozym 435‐Catalyzed Syntheses of Polyesters and Polyamides of Medicinal and Industrial Relevance

et al. 2014

Self Cite

View full text Add to dashboard Cite

The adverse impact of chemical and biochemical waste on the environment and human health poses a serious challenge in today's World. The best way to address these challenges is to reduce the waste by developing more efficient processes and technologies, based on the principles of "green chemistry". Some of these synthetic approaches involving the chemoenzymatic synthetic methodologies are discussed herein. These lead to the formation of unique nanomaterials with diverse applications, such as drugs/gene delivery systems, flame retardant materials, conducting polymers, controlled release systems, diagnostic agents, and polymeric electrolytes for nanocrystalline solar cells.

show abstract

Nanopesticide: Future Application of Nanomaterials in Plant Protection

Djiwanti

Kaushik

2019

Plant Nanobionics

View full text Add to dashboard Cite

Development of Poly(ethylene glycol) Based Amphiphilic Copolymers for Controlled Release Delivery of Carbofuran

Cited by 59 publications

References 22 publications

Development of slow release formulations of β-carotene employing amphiphilic polymers and their release kinetics study in water and different pH conditions

Development of slow release formulations of β-carotene employing amphiphilic polymers and their release kinetics study in water and different pH conditions

Novozym 435‐Catalyzed Syntheses of Polyesters and Polyamides of Medicinal and Industrial Relevance

Nanopesticide: Future Application of Nanomaterials in Plant Protection

Contact Info

Product

Resources

About