Development of PMMA-Mon-CNT bone cement with superior mechanical properties and favorable biological properties for use in bone-defect treatment

Pahlevanzadeh, Farnoosh; Bakhsheshi‐Rad, Hamid Reza; Ismail, Ahmad Fauzi; Aziz, Md. Maniruzzaman A.; Chen, Daniel

doi:10.1016/j.matlet.2018.12.049

Cited by 62 publications

(44 citation statements)

References 13 publications

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“…Although the introduction of HEMA in the liquid phase reduced the mechanical properties of bone cement, the compression strength of the saturated absorbent samples was still between the cancellous bone and the cortical bones ranging from 10.44 to 153.59 MPa 34,35. In addition, the decreased elastic modulus of the HMBC was close to the cortical bone in the range of 0.01–3 GPa,36 which would avoid the fractures caused by excessive elasticity, and also provided adequate support to the human bones.…”

Section: Resultsmentioning

confidence: 95%

HEMA‐Modified Expandable P(MMA‐AA) Bone Cement with Dual Water Absorption Networks

Chen

Tang

Zhao

et al. 2020

Macro Materials & Eng

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Although the shrinkage of polymethyl methacrylate (PMMA) bone cement has been tackled by the poly(methyl methacrylate‐co‐acrylic acid) [P(MMA‐AA)] bone cement due to the expandable P(MMA‐AA) copolymer in the solid phase, the hydrophobicity of PMMA and its solidification restrict simulated body fluid (SBF) diffusion and expansion properties. In this research, hydroxyethyl methacrylate (HEMA)‐modified P(MMA‐AA) bone cement (HMBC) is obtained by introducing HEMA into the liquid phase of P(MMA‐AA) bone cement. It is assumed that the dual water absorption networks can promote the SBF absorption capacity, thus resulting in the increased expansion behavior. The results demonstrate that the introduction of HEMA improves the hydrophilicity of the bulk. SBF absorption efficiency and swelling efficiency are promoted in the primary step of expansion. The porous structure of HMBC contributes to the increased SBF absorption and swelling in the second step of expansion behavior. Meanwhile, the remarkable absorption ratio and expansion ratio reach 88.5% and 97.4%, respectively. Furthermore, enhanced biocompatibility and osteogenesis activity provide HMBC as a promising biomaterial in the clinical setting.

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Section: Resultsmentioning

confidence: 95%

HEMA‐Modified Expandable P(MMA‐AA) Bone Cement with Dual Water Absorption Networks

Chen

Tang

Zhao

et al. 2020

Macro Materials & Eng

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“…Besides the mentioned investigations, many works have been done in the field of the influences of CNTs composite on PMMA-based BCs. Besides, Pahlevanzadeh et al [ 89 ] developed PMMA-monticellite (Mon)-CNTs-based BCs with great mechanical characteristics and desirable biological attributes for utilizing in bone-defect treatment. They synthesized and characterized a new PMMA-based BCs comprising CNTs and Mon for the treatment of bone defect and proved that more appropriate mechanical properties were obtained in the PMMA-Mon-CNTs composite compared to the PMMA and PMMA-Mon-based BCs because of the unparalleled resistance of CNTs to crack formation and propagation [ 89 ].…”

Section: Cnts In Pmma-based Bcsmentioning

confidence: 99%

Polymethyl Methacrylate-Based Bone Cements Containing Carbon Nanotubes and Graphene Oxide: An Overview of Physical, Mechanical, and Biological Properties

et al. 2020

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Every year, millions of people in the world get bone diseases and need orthopedic surgery as one of the most important treatments. Owing to their superior properties, such as acceptable biocompatibility and providing great primary bone fixation with the implant, polymethyl methacrylate (PMMA)-based bone cements (BCs) are among the essential materials as fixation implants in different orthopedic and trauma surgeries. On the other hand, these BCs have some disadvantages, including Lack of bone formation and bioactivity, and low mechanical properties, which can lead to bone cement (BC) failure. Hence, plenty of studies have been concentrating on eliminating BC failures by using different kinds of ceramics and polymers for reinforcement and also by producing composite materials. This review article aims to evaluate mechanical properties, self-setting characteristics, biocompatibility, and bioactivity of the PMMA-based BCs composites containing carbon nanotubes (CNTs), graphene oxide (GO), and carbon-based compounds. In the present study, we compared the effects of CNTs and GO as reinforcement agents in the PMMA-based BCs. Upcoming study on the PMMA-based BCs should concentrate on trialing combinations of these carbon-based reinforcing agents as this might improve beneficial characteristics.

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“…Similar to any other TE process, BTE involves a scaffold matrix with/without cells and biological cues for an effective result, i.e., bone reproduction. The biomaterials employed for building a bone scaffold matrix consist of polymers (natural or synthetic), natural-synthetic polymeric blends, and ceramics or polymer-ceramic composites [77][78][79][80]. One of the most broadly utilized polymers for bone reproduction is CS.…”

Section: Bone Regenerationmentioning

confidence: 99%

“…One of the most broadly utilized polymers for bone reproduction is CS. Its cationic character is essential for BTE fields as CS might form polyelectrolyte complexes with anionic biological macromolecules [77][78][79][80]. Particularly, anionic GAGs including heparin and heparan sulfate modulate the action of numerous cytokines and growth factors crucial to bone reproduction.…”

Section: Bone Regenerationmentioning

confidence: 99%

“…Particularly, anionic GAGs including heparin and heparan sulfate modulate the action of numerous cytokines and growth factors crucial to bone reproduction. Therefore, CS treatment with GAGs or CS incorporated with GAGs in vivo might play a vital role in making use of growth factors to assist in bone creation [50,[77][78][79][80]. A crucial characteristic of CS regarding TE is the simplicity with which it is usually functionalized.…”

Section: Bone Regenerationmentioning

confidence: 99%

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Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

et al. 2020

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Chitosan (CS) has gained particular attention in biomedical applications due to its biocompatibility, antibacterial feature, and biodegradability. Hence, many studies have focused on the manufacturing of CS films, scaffolds, particulate, and inks via different production methods. Nowadays, with the possibility of the precise adjustment of porosity size and shape, fiber size, suitable interconnectivity of pores, and creation of patient-specific constructs, 3D printing has overcome the limitations of many traditional manufacturing methods. Therefore, the fabrication of 3D printed CS scaffolds can lead to promising advances in tissue engineering and regenerative medicine. A review of additive manufacturing types, CS-based printed constructs, their usages as biomaterials, advantages, and drawbacks can open doors to optimize CS-based constructions for biomedical applications. The latest technological issues and upcoming capabilities of 3D printing with CS-based biopolymers for different applications are also discussed. This review article will act as a roadmap aiming to investigate chitosan as a new feedstock concerning various 3D printing approaches which may be employed in biomedical fields. In fact, the combination of 3D printing and CS-based biopolymers is extremely appealing particularly with regard to certain clinical purposes. Complications of 3D printing coupled with the challenges associated with materials should be recognized to help make this method feasible for wider clinical requirements. This strategy is currently gaining substantial attention in terms of several industrial biomedical products. In this review, the key 3D printing approaches along with revealing historical background are initially presented, and ultimately, the applications of different 3D printing techniques for fabricating chitosan constructs will be discussed. The recognition of essential complications and technical problems related to numerous 3D printing techniques and CS-based biopolymer choices according to clinical requirements is crucial. A comprehensive investigation will be required to encounter those challenges and to completely understand the possibilities of 3D printing in the foreseeable future.

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Development of PMMA-Mon-CNT bone cement with superior mechanical properties and favorable biological properties for use in bone-defect treatment

Cited by 62 publications

References 13 publications

HEMA‐Modified Expandable P(MMA‐AA) Bone Cement with Dual Water Absorption Networks

HEMA‐Modified Expandable P(MMA‐AA) Bone Cement with Dual Water Absorption Networks

Polymethyl Methacrylate-Based Bone Cements Containing Carbon Nanotubes and Graphene Oxide: An Overview of Physical, Mechanical, and Biological Properties

Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

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