2021
DOI: 10.1016/j.ejmp.2020.12.009
|View full text |Cite
|
Sign up to set email alerts
|

Development of patient-specific 3D models from histopathological samples for applications in radiation therapy

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
4
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
4

Relationship

1
3

Authors

Journals

citations
Cited by 4 publications
(4 citation statements)
references
References 22 publications
0
4
0
Order By: Relevance
“…The aim of this study was to examine the accuracy of approximate methods for the fast calculation of patient-specific microdosimetric distributions. Variation in cell spacing and nucleus 0.246  0.004 0.245  0.005 0.247  0.003 Ir 192 0.50  0.01 0.49  0.01 0.495  0.009 0.502  0.008 Yb 169 0.89  0.01 0.803  0.03 0.839  0.009 0.85  0.02 I 125 1.001  0.004 0.797  0.001 0.901  0.002 0.89  0.01 y d ¯m keV m ⎡ ⎣ ⎤ ⎦ Co 60 0.74  0.02 0.66  0.02 0.71  0.04 0.72  0.02 Ir 192 1.22  0.05 1.10  0.03 1.17  0.03 1.19  0.03 Yb 169 1.68  0.03 1.470  0.008 1.60  0.02 1.60  0.04 I 125 2.173  0.009 1.866  0.004 2.062  0.005 2.06  0.03 radius of only a few mm was observed across multiple lung adenocarcinoma histopathological samples in a previous study (DeCunha et al 2021). This small variation suggests that conclusions drawn from the single sample investigated should be applicable to other lung adenocarcinoma samples.…”
Section: Discussionmentioning
confidence: 71%
See 1 more Smart Citation
“…The aim of this study was to examine the accuracy of approximate methods for the fast calculation of patient-specific microdosimetric distributions. Variation in cell spacing and nucleus 0.246  0.004 0.245  0.005 0.247  0.003 Ir 192 0.50  0.01 0.49  0.01 0.495  0.009 0.502  0.008 Yb 169 0.89  0.01 0.803  0.03 0.839  0.009 0.85  0.02 I 125 1.001  0.004 0.797  0.001 0.901  0.002 0.89  0.01 y d ¯m keV m ⎡ ⎣ ⎤ ⎦ Co 60 0.74  0.02 0.66  0.02 0.71  0.04 0.72  0.02 Ir 192 1.22  0.05 1.10  0.03 1.17  0.03 1.19  0.03 Yb 169 1.68  0.03 1.470  0.008 1.60  0.02 1.60  0.04 I 125 2.173  0.009 1.866  0.004 2.062  0.005 2.06  0.03 radius of only a few mm was observed across multiple lung adenocarcinoma histopathological samples in a previous study (DeCunha et al 2021). This small variation suggests that conclusions drawn from the single sample investigated should be applicable to other lung adenocarcinoma samples.…”
Section: Discussionmentioning
confidence: 71%
“…( ) calculation Patient-specific microdosimetric distributions are microdosimetric functions determined in cell and nucleus volumes whose sizes are obtained from histopathological samples (Poole et al 2015, DeCunha et al 2021. We have found that calculation of such distributions require computational resources on the order of 10 000 core hours using the methods described in this work for Co 60 and thus are not currently viable for use in a clinical environment.…”
Section: Fixed Radius Models For F Ymentioning
confidence: 99%
“…For both voxel sizessimulated, we calculated microdosimetricspectra in 39 different spherical target sizessuch that predictionsof energydeposition probabilitiesin targetswhose sizes correspondto biologicaltargetsof interest can be made. One such implementation has been described in past work by DeCunha et al (2021aDeCunha et al ( , 2021b, which demonstratedthe feasibility of performingpatient-specific or tissue-specific microdosimetry (DeCunha et al 2021b(DeCunha et al , 2021a. By weighting a series of microdosimetric spectra in various target sizes accordingto a patient's known cell and nucleus-sizedistributions, a patient-specific microdosimetric distribution can be calculated.…”
Section: Target Size Weighting Of Microdosimetric Spectramentioning
confidence: 99%
“…Different methods [20][21][22][23][24][25][26] have been proposed to model cell population. Barberet et al [27] implemented a method based on high resolution confocal imaging and ion beam analysis in order to obtain realistic cell nucleus geometry; however this method requires a fully dedicated image reconstruction process that is most of the time not easily accessible to users.…”
Section: Introductionmentioning
confidence: 99%