2021
DOI: 10.1016/j.ejmp.2021.07.016
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CPOP: An open source C++ cell POPulation modeler for radiation biology applications

Abstract: Multicellular tumor spheroids are realistic in-vitro systems used in radiation biology research to study the effect of anticancer drugs or to evaluate the resistance of cancer cells under specific conditions. When combining the modeling of spheroids together with the simulation of radiation using Monte Carlo methods, one could estimate cell and DNA damage to be compared with experimental data. We developed a Cell Population (CPOP) modeler combined to Geant4 simulations in order to tackle how energy depositions… Show more

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Cited by 2 publications
(1 citation statement)
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“…Upcoming developments will favor the integration of relevant features that have been tested so far through Geant4-DNA simulations. As an example, we can mention the integration of various cell population models, specifically 3D cell populations, from the C++ Cell POPulation modeler (CPOP) already compliant with the Geant4 toolkit (Maigne et al 2021). We will propose the same integration for the IDDRRA platform to score radiation-induced DNA damage with a user-friendly simulation of different DNA molecules (Chatzipapas et al 2021a) The GATE framework offers access to information on single particle interactions, thus, enabling the calculation of single particle LET in a voxelized patient geometry.…”
Section: Radionuclide Therapymentioning
confidence: 99%
“…Upcoming developments will favor the integration of relevant features that have been tested so far through Geant4-DNA simulations. As an example, we can mention the integration of various cell population models, specifically 3D cell populations, from the C++ Cell POPulation modeler (CPOP) already compliant with the Geant4 toolkit (Maigne et al 2021). We will propose the same integration for the IDDRRA platform to score radiation-induced DNA damage with a user-friendly simulation of different DNA molecules (Chatzipapas et al 2021a) The GATE framework offers access to information on single particle interactions, thus, enabling the calculation of single particle LET in a voxelized patient geometry.…”
Section: Radionuclide Therapymentioning
confidence: 99%