Development of Oromucosal Dosage Forms by Combining Electrospinning and Inkjet Printing

Palo, Mirja; Kogermann, Karin; Laidmäe, Ivo; Meos, Andres; Preis, Maren; Heinämäki, Jyrki; Sandler, Niklas

doi:10.1021/acs.molpharmaceut.6b01054

Cited by 34 publications

(21 citation statements)

References 68 publications

(191 reference statements)

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“…If the required volume is not ejected because of blockage, the target dose cannot be reached. However, similar is the case when the calculated drug content is not achieved because of a mismatch of theoretical and practical wet film thickness during solvent casting of oromucosal films [103]. Furthermore, the drug has to be stable in the printing fluid during production and storage as well as in the polymer solution using the casting method.…”

Section: Pharmaceutical Inkjet Printingmentioning

confidence: 97%

“…Furthermore, the oromucosal preparations should be sufficiently wetted by the applied printing fluid avoiding irregularities. A new approach is to produce the films by electrospinning gaining a fibrous structure with high surface area [103]. Pre-coatings containing high molecular polyethylene glycol aim at a better spreading of hydrophilic fluid on the films [98].…”

Section: Pharmaceutical Inkjet Printingmentioning

confidence: 99%

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Oromucosal films: from patient centricity to production by printing techniques

Tian

Orlu

Woerdenbag

et al. 2019

Expert Opinion on Drug Delivery

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Introduction: Oromucosal films, comprising mucoadhesive buccal films (MBFs) and orodispersible films (ODFs), are considered patient-centric dosage forms. Target groups are patients with special needs. Various active pharmaceutical ingredients have been shown to be suitable for oromucosal film production. A shift is seen in the production techniques, from conventional solvent casting to printing techniques. Areas covered: In this review, the patient acceptability of oromucosal films is discussed. An overview is given of the small molecule drugs, biopharmaceuticals and herbal extracts that have been incorporated so far. Finally, the current state of 2D and 3D printing techniques for production purposes is discussed. Expert opinion: The patient-centric features are important for the further development and acceptance of this oral solid dosage form. Oromucosal films perfectly fit in the current attention for personalized medicine. Both MBFs and ODFs are intended for either a local or a systemic effect. For buccal absorption, sufficient mucoadhesion is one of the most important criteria an oromucosal film must comply with. For the preparation, the solvent casting technique is still predominately used. Some limitations of this production method can be tackled by printing techniques. However, these novel techniques introduce new requirements, yet to be set, for oromucosal film preparation.

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Section: Pharmaceutical Inkjet Printingmentioning

confidence: 97%

Section: Pharmaceutical Inkjet Printingmentioning

confidence: 99%

Oromucosal films: from patient centricity to production by printing techniques

Tian

Orlu

Woerdenbag

et al. 2019

Expert Opinion on Drug Delivery

Self Cite

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“…For a local drug delivery to the oral mucosa, cross‐linked gelatin was electrospun to form patches containing antifungal agents due to its biocompatibility and mucoadhesive property . The varying cross‐linking degrees of gelatin allow the adjustable and sustained release of antifungal agents in the oral cavity to maintain the therapeutic level . To fabricate an oral formulation for drug releasing via the sublingual route, PVA/sodium alginate blend was chosen as the patch matrix to enable sustained drug release over 10 h .…”

Section: Fabrication Of Electrospun Drug Delivery Systems and The Relmentioning

confidence: 99%

Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy

Ding

Zhang

et al. 2018

Adv Funct Materials

196

138

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The versatile electrospinning technique is recognized as an efficient strategy to deliver active pharmaceutical ingredients and has gained tremendous progress in drug delivery, tissue engineering, cancer therapy, and disease diagnosis. Numerous drug delivery systems fabricated through electrospinning regarding the carrier compositions, drug incorporation techniques, release kinetics, and the subsequent therapeutic efficacy are presented herein. Targeting for distinct applications, the composition of drug carriers vary from natural/synthetic polymers/blends, inorganic materials, and even hybrids. Various drug incorporation approaches through electrospinning are thoroughly discussed with respect to the principles, benefits, and limitations. To meet the various requirements in actual sophisticated in vivo environments and to overcome the limitations of a single carrier system, feasible combinations of multiple drug-inclusion processes via electrospinning could be employed to achieve programmed, multi-staged, or stimuli-triggered release of multiple drugs. The therapeutic efficacy of the designed electrospun drugeluting systems is further verified in multiple biomedical applications and is comprehensively overviewed, demonstrating promising potential to address a variety of clinical challenges.

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“…The use of these polymeric bi-layered carriers could be beneficial for delivering APIs through the dermal or buccal administration ways. In these DDSs, the APIs can be incorporated by inkjet printing [29,75]. The precision of liquid dosing and location of solution deposition provided by inkjet printing could be highly beneficial for increasing the efficacy-dose ratio in antimicrobial preparations [30,76].…”

Section: Surface Properties During Inkjet Printingmentioning

confidence: 99%

Bi-Layered Polymer Carriers with Surface Modification by Electrospinning for Potential Wound Care Applications

et al. 2019

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Polymeric wound dressings with advanced properties are highly preferred formulations to promote the tissue healing process in wound care. In this study, a combinational technique was investigated for the fabrication of bi-layered carriers from a blend of polyvinyl alcohol (PVA) and sodium alginate (SA). The bi-layered carriers were prepared by solvent casting in combination with two surface modification approaches: electrospinning or three-dimensional (3D) printing. The bi-layered carriers were characterized and evaluated in terms of physical, physicochemical, adhesive properties and for the safety and biological cell behavior. In addition, an initial inkjet printing trial for the incorporation of bioactive substances for drug delivery purposes was performed. The solvent cast (SC) film served as a robust base layer. The bi-layered carriers with electrospun nanofibers (NFs) as the surface layer showed improved physical durability and decreased adhesiveness compared to the SC film and bi-layered carriers with patterned 3D printed layer. Thus, these bi-layered carriers presented favorable properties for dermal use with minimal tissue damage. In addition, electrospun NFs on SC films (bi-layered SC/NF carrier) provided the best physical structure for the cell adhesion and proliferation as the highest cell viability was measured compared to the SC film and the carrier with patterned 3D printed layer (bi-layered SC/3D carrier). The surface properties of the bi-layered carriers with electrospun NFs showed great potential to be utilized in advanced technical approach with inkjet printing for the fabrication of bioactive wound dressings.Pharmaceutics 2019, 11, 678 2 of 21 ingredients and/or active pharmaceutical ingredients (APIs), such as antibiotics, anti-inflammatory agents, vitamins and growth factors, are continuously being developed [3,5].Wound dressings are produced by different methods depending on the desired structure and the materials used. In the current study, three commonly applied methods were exploited: solvent casting, extrusion-type three-dimensional (3D) printing and electrospinning. In solvent casting, polymeric films are prepared from drying of viscous solutions of polymer(s) with/without additives and active substances in a uniformly distributed layer [6,7]. Due to the simplicity of this method, solvent casting can be time-consuming, and the properties and stability of the films are dependent on the materials used [6,7]. Nevertheless, solvent cast (SC) polymer films are structurally more robust, and highly suitable to be exploited as base layer in multi-layered formulations.Electrospinning is a versatile technology for the fabrication of polymeric fibers with good diffusion characteristics and high surface area to volume ratio, which are beneficial for wound care applications to hinder bleeding, absorb excessive wound fluid and promote tissue regeneration [4,8,9]. The stability, reproducibility and production yield of the electrospinning process is highly dependent on the compatibility of the material...

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Development of Oromucosal Dosage Forms by Combining Electrospinning and Inkjet Printing

Cited by 34 publications

References 68 publications

Oromucosal films: from patient centricity to production by printing techniques

Oromucosal films: from patient centricity to production by printing techniques

Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy

Bi-Layered Polymer Carriers with Surface Modification by Electrospinning for Potential Wound Care Applications

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