Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy

Abstract

The versatile electrospinning technique is recognized as an efficient strategy to deliver active pharmaceutical ingredients and has gained tremendous progress in drug delivery, tissue engineering, cancer therapy, and disease diagnosis. Numerous drug delivery systems fabricated through electrospinning regarding the carrier compositions, drug incorporation techniques, release kinetics, and the subsequent therapeutic efficacy are presented herein. Targeting for distinct applications, the composition of drug carriers vary from natural/synthetic polymers/blends, inorganic materials, and even hybrids. Various drug incorporation approaches through electrospinning are thoroughly discussed with respect to the principles, benefits, and limitations. To meet the various requirements in actual sophisticated in vivo environments and to overcome the limitations of a single carrier system, feasible combinations of multiple drug-inclusion processes via electrospinning could be employed to achieve programmed, multi-staged, or stimuli-triggered release of multiple drugs. The therapeutic efficacy of the designed electrospun drugeluting systems is further verified in multiple biomedical applications and is comprehensively overviewed, demonstrating promising potential to address a variety of clinical challenges.

Effects of Gradient and Offset Architectures on the Mechanical and Biological Properties of 3-D Melt Electrowritten (MEW) Scaffolds

“…Enhanced solubility, permeability, and porousity of electrospun fibers can further increase the surface area for faster degradation. 22,23 In our study, the melt electrowritten filaments displayed a smaller fiber diameter and greater surface area (Figures S7, S8, and S9, Table S2 in Supporting Information) compared to FDM 3D-printed fibers. Total porosity of the scaffold increased by generating sufficiently large gaps between the filaments to support cells and allowed higher resolution for printing small pore sizes (Figure S10, Supporting Information).…”

Nonadherent Zwitterionic Composite Nanofibrous Membrane with a Halloysite Nanocarrier for Sustained Wound Anti-Infection and Cutaneous Regeneration

“…16,33 Besides, the compact affinity between the hydrophilic polymer matrix and the hydrophilic TCH could further slow the diffusion rate of the drug. 68 Additionally, according to Figure 6C, the initial drug release rate accelerated with the content of the T-HNTs. PCL/PDSM-20% with the sustained drug release property could maintain high incipient drug release, on account of the initial rapid release of the electrostatically adsorbed TCH.…”

“…Meanwhile, the complete drug release time was further extended (PCL/PDSM-20% membrane could maintain release over 16 days) with increasing the content of the T-HNTs. The sustained drug release profile was attributed to the diffusion resistance of the nanotube and end-capping effect of the polymer substrate. , Besides, the compact affinity between the hydrophilic polymer matrix and the hydrophilic TCH could further slow the diffusion rate of the drug . Additionally, according to Figure C, the initial drug release rate accelerated with the content of the T-HNTs.…”

Using Humidity to Control the Morphology and Properties of Electrospun BioPEGylated Polyhydroxybutyrate Scaffolds

“…Consistent with previous reports, OECs cultivated on solvent-cast films of PHB displayed characteristics consistent with healthy growth, including significant filopodiae (Figure ). Electrospun scaffolds are reported to promote cell growth and have potential applications in wound healing and tissue engineering. , In the study, electrospun scaffolds promoted OEC growth, increasing the average cell spread from 110 ± 18 to 187 ± 16 μm; a 70% increase (Figures and ). In contrast, the average spread of OECs on electrospun bioPEGylated PHB scaffolds was 260 ± 20 μm, approximately twice the size of those determined on solvent-cast films of PHB- b -DEG (+108%, Figure ).…”