Development of Oral Delivery Systems with Enhanced Antioxidant and Anticancer Activity: Coix Seed Oil and β-Carotene Coloaded Liposomes

Bai, Chen; Zheng, Jingxia; Li, Zhao; Chen, Lili; Xiong, Hua; McClements, David Julian

doi:10.1021/acs.jafc.8b04879

Cited by 55 publications

(42 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Carotenoids (including beta-carotene, lycopene, lutein, and hundreds of related compounds) act as antioxidants and may reduce the risks of cancer and other diseases. The food sources of carotenoids are highly pigmented fruits and vegetables (apricot, broccoli, cantaloupe, carrots, pumpkin, spinach, sweet potatoes, and tomatoes) [168]. 4.…”

mentioning

confidence: 99%

Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women

2020

View full text Add to dashboard Cite

Menopause is clinically diagnosed as a condition when a woman has not menstruated for one year. During the menopausal transition period, there is an emergence of various lipid metabolic disorders due to hormonal changes, such as decreased levels of estrogens and increased levels of circulating androgens; these may lead to the development of metabolic syndromes including cardiovascular diseases and type 2 diabetes. Dysregulation of lipid metabolism affects the body fat mass, fat-free mass, fatty acid metabolism, and various aspects of energy metabolism, such as basal metabolic ratio, adiposity, and obesity. Moreover, menopause is also associated with alterations in the levels of various lipids circulating in the blood, such as lipoproteins, apolipoproteins, low-density lipoproteins (LDLs), high-density lipoproteins (HDL) and triacylglycerol (TG). Alterations in lipid metabolism and excessive adipose tissue play a key role in the synthesis of excess fatty acids, adipocytokines, proinflammatory cytokines, and reactive oxygen species, which cause lipid peroxidation and result in the development of insulin resistance, abdominal adiposity, and dyslipidemia. This review discusses dietary recommendations and beneficial compounds, such as vitamin D, omega-3 fatty acids, antioxidants, phytochemicals—and their food sources—to aid the management of abnormal lipid metabolism in postmenopausal women.

show abstract

mentioning

confidence: 99%

Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women

2020

View full text Add to dashboard Cite

show abstract

“…As they have both hydrophilic and hydrophobic domains inside, they can be used to encapsulate both polar and nonpolar bioactive compounds (Ajeeshkumar et al., 2021). A variety of methods can be used to fabricate these systems, including homogenization sonication, lipid film hydration, solvent dispersion, membrane extrusion, supercritical fluid, and detergent removal methods (Amoabediny et al., 2018; Bai et al., 2018; Bozzuto & Molinari, 2015; Daeihamed et al., 2017; Z. Huang et al., 2014; J.‐S. Kim, 2016; W. Liu et al., 2015; Mozafari et al., 2008; Nekkanti et al., 2015; Peng et al., 2018; Wakaskar, 2018).…”

Section: Nano‐based Delivery Systemsmentioning

confidence: 99%

Vitamin A fortification: Recent advances in encapsulation technologies

Maurya

Shakya

Bashir

et al. 2022

Comp Rev Food Sci Food Safe

Self Cite

View full text Add to dashboard Cite

Vitamin A is an essential micronutrient whose deficiency is still a major health concern in many regions of the world. It plays an essential role in human growth and development, immunity, and vision, but may also help prevent several other chronic diseases. The total amount of vitamin A in the human diet often falls below the recommended dietary allowance of approximately 900–1000 μ$ \umu $g/day for a healthy adult. Moreover, a significant proportion of vitamin A may be degraded during food processing, storage, and distribution, thereby reducing its bioactivity. Finally, the vitamin A in some foods has a relatively low bioavailability, which further reduces its efficacy. The World Health Organization has recommended fortification of foods and beverages as a safe and cost‐effective means of addressing vitamin A deficiency. However, there are several factors that must be overcome before effective fortified foods can be developed, including the low solubility, chemical stability, and bioavailability of this oil‐soluble vitamin. Consequently, strategies are required to evenly disperse the vitamin throughout food matrices, to inhibit its chemical degradation, to avoid any adverse interactions with any other food components, to ensure the food is palatable, and to increase its bioavailability. In this review article, we discuss the chemical, physical, and nutritional attributes of vitamin A, its main dietary sources, the factors contributing to its current deficiency, and various strategies to address these deficiencies, including diet diversification, biofortification, and food fortification.

show abstract

“…There are also research works focused on improving the oral stability of carotenoids. Studies conducted by Jhan et al [170] presented the method for efficient encapsulation of lycopene in double-loaded liposomes consisting lycopene β-cyclodextrin complex, cholesterol and soy lecithin, whereas simple liposomes were found to be effective nanocarriers for β-carotene [171].…”

Section: Advances In Oral Deliverymentioning

confidence: 99%

Recent Advances in the Structural Design of Photosensitive Agent Formulations Using “Soft” Colloidal Nanocarriers

et al. 2020

View full text Add to dashboard Cite

The growing demand for effective delivery of photosensitive active compounds has resulted in the development of colloid chemistry and nanotechnology. Recently, many kinds of novel formulations with outstanding pharmaceutical potential have been investigated with an expansion in the design of a wide variety of “soft” nanostructures such as simple or multiple (double) nanoemulsions and lipid formulations. The latter can then be distinguished into vesicular, including liposomes and “smart” vesicles such as transferosomes, niosomes and ethosomes, and non-vesicular nanosystems with solid lipid nanoparticles and nanostructured lipid carriers. Encapsulation of photosensitive agents such as drugs, dyes, photosensitizers or antioxidants can be specifically formulated by the self-assembly of phospholipids or other amphiphilic compounds. They are intended to match unique pharmaceutic and cosmetic requirements and to improve their delivery to the target site via the most common, i.e., transdermal, intravenous or oral administration routes. Numerous surface modifications and functionalization of the nanostructures allow increasing their effectiveness and, consequently, may contribute to the treatment of many diseases, primarily cancer. An increasing article number is evidencing significant advances in applications of the different classes of the photosensitive agents incorporated in the ”soft” colloidal nanocarriers that deserved to be highlighted in the present review.

show abstract

Development of Oral Delivery Systems with Enhanced Antioxidant and Anticancer Activity: Coix Seed Oil and β-Carotene Coloaded Liposomes

Cited by 55 publications

References 30 publications

Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women

Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women

Vitamin A fortification: Recent advances in encapsulation technologies

Recent Advances in the Structural Design of Photosensitive Agent Formulations Using “Soft” Colloidal Nanocarriers

Contact Info

Product

Resources

About