Development of novel self-assembled DS-PLGA hybrid nanoparticles for improving oral bioavailability of vincristine sulfate by P-gp inhibition

Ling, Guixia; Zhang, Peng; Zhang, Wenping; Sun, Jin; Meng, Xiaoxue; Qin, Yimeng; Deng, Yihui; Zhang, He

doi:10.1016/j.jconrel.2010.08.010

Cited by 122 publications

(71 citation statements)

References 36 publications

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“…This interesting efflux pump inhibitor effect has also been reported in studies of several polymers, including Pluronic P85, Myrj 52 and chitosan-4-thiobutylamidine, polyethylene glycols, amphiphilic block copolymers, dendrimers, thiolated polymers, and dextran sulphate-PLGA hybrid (Werle, 2008;Ling et al, 2010). Jodoin, Demeule, Béliveau (2002) and Honda et al (2004) also demonstrated that polyphenols of green tea and compounds of grapefruit juice represent natural polymeric efflux pump inhibitors.…”

Section: Resultssupporting

confidence: 69%

“…Several studies have demonstrated that P-gp inhibitors (e.g., verapamil, VER) can improve the bioavailability of a large number of molecules (Werle, 2008;Ling et al, 2010). Takizawa et al (2013) demonstrated the effects of 20 common pharmaceutical excipients (diluents, disintegrants, binders, lubricants and sustained release substrate) on the mucosal membrane and how their effects differ in regions of the small intestine.…”

Section: Introductionmentioning

confidence: 99%

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A novel approach in mucoadhesive drug delivery system to improve zidovudine intestinal permeability

Pedreiro

Cury

Chaud

et al. 2016

Braz. J. Pharm. Sci.

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Zidovudine (AZT) mucoadhesive solid dispersions (SD) were prepared using a sodium starch glycolate (SSG) and hypromellose phthalate (HPMCP) mixtures as carrier to enhance the intestinal permeability and bioavailability of zidovudine. SDs were prepared using the co-precipitation method followed by solvent evaporation and characterized according to their physicochemical properties such as particle size, crystallinity, thermal behavior, and liquid uptake ability. In vitro drug dissolution, mucoadhesiveness and AZT intestinal permeability were also determined. Thermal behavior and X-ray diffraction patterns demonstrated the amorphous state of AZT in SD systems. The HPMCP polymer restricted the liquid uptake ability in the acid medium; however, this property significantly increased with higher pH values. SDs allowed drug dissolution to occur in a controlled manner. HPMCP decreased the dissolution rates in the acid medium. The mucoadhesiveness of SDs was demonstrated and the permeability of AZT carried in solid dispersions was significantly improved. The effect of the SD carrier polymers on blocking efflux pump can be an important approach to improve the bioavailability of AZT.Uniterms: Zidovudine. Solid dispersion. Mucoadhesion. P-glycoprotein. Intestinal permeability.

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Section: Resultssupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

A novel approach in mucoadhesive drug delivery system to improve zidovudine intestinal permeability

Pedreiro

Cury

Chaud

et al. 2016

Braz. J. Pharm. Sci.

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“…It has been reported that an electrostatic interaction between cationic drug and counterionic polymers or small molecules plays a prominent role in the development of nanocarriers. 17,[22][23][24][25][26][27][28][29] MTO was incorporated into a mixed lipid core because of the strong electrostatic interaction between DS and GcNa. Moreover, a comparative analysis of the zeta potential of the blank NLCs 4), and MTO-TMLGNs (−28.7±0.4) further confirmed the role of the electrostatic interaction between the MTO and GcNa/DS.…”

Section: Results and Discussion Characterization Of Tmlgnsmentioning

confidence: 99%

Synergistic and complete reversal of the multidrug resistance of mitoxantrone hydrochloride by three-in-one multifunctional lipid-sodium glycocholate nanocarriers based on simultaneous BCRP and Bcl-2 inhibition

Ling¹,

Zhang²,

Zhang³

et al. 2016

IJN

Self Cite

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Multidrug resistance (MDR) is a severe obstacle to successful chemotherapy due to its complicated nature that involves multiple mechanisms, such as drug efflux by transporters (P-glycoprotein and breast cancer resistance protein, BCRP) and anti-apoptotic defense (B-cell lymphoma, Bcl-2). To synergistically and completely reverse MDR by simultaneous inhibition of pump and non-pump cellular resistance, three-in-one multifunctional lipid-sodium glycocholate (GcNa) nanocarriers (TMLGNs) have been designed for controlled co-delivery of water-soluble cationic mitoxantrone hydrochloride (MTO), cyclosporine A (CsA – BCRP inhibitor), and GcNa (Bcl-2 inhibitor). GcNa and dextran sulfate were incorporated as anionic compounds to enhance the encapsulation efficiency of MTO (up to 97.8%±1.9%) and sustain the release of cationic MTO by electrostatic interaction. The results of a series of in vitro and in vivo investigations indicated that the TMLGNs were taken up by the resistant cancer cells by an endocytosis pathway that escaped the efflux induced by BCRP, and the simultaneous release of CsA with MTO further efficiently inhibited the efflux of the released MTO by BCRP; meanwhile GcNa induced the apoptosis process, and an associated synergistic antitumor activity and reversion of MDR were achieved because the reversal index was almost 1.0.

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“…Ionic excipients induce electrostatic interactions with drugs, thereby improving their incorporation efficiency. [79][80][81] Lipid-PLGA hybrid nanoparticles enable multiple drug combination therapy and temporal release of more than two drugs. An interesting nanoparticulate delivery system was proposed to target tumor cells and neovasculature at the same time.…”

Section: Core-shell Type Hybrid Nanoparticlesmentioning

confidence: 99%

Concepts and practices used to develop functional PLGA-based nanoparticulate systems

Sah¹,

Thoma²,

Desu³

et al. 2013

IJN

191

127

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Abstract:The functionality of bare polylactide-co-glycolide (PLGA) nanoparticles is limited to drug depot or drug solubilization in their hard cores. They have inherent weaknesses as a drug-delivery system. For instance, when administered intravenously, the nanoparticles undergo rapid clearance from systemic circulation before reaching the site of action. Furthermore, plain PLGA nanoparticles cannot distinguish between different cell types. Recent research shows that surface functionalization of nanoparticles and development of new nanoparticulate dosage forms help overcome these delivery challenges and improve in vivo performance. Immense research efforts have propelled the development of diverse functional PLGA-based nanoparticulate delivery systems. Representative examples include PEGylated micelles/nanoparticles (PEG, polyethylene glycol), polyplexes, polymersomes, core-shelltype lipid-PLGA hybrids, cell-PLGA hybrids, receptor-specific ligand-PLGA conjugates, and theranostics. Each PLGA-based nanoparticulate dosage form has specific features that distinguish it from other nanoparticulate systems. This review focuses on fundamental concepts and practices that are used in the development of various functional nanoparticulate dosage forms. We describe how the attributes of these functional nanoparticulate forms might contribute to achievement of desired therapeutic effects that are not attainable using conventional therapies. Functional PLGA-based nanoparticulate systems are expected to deliver chemotherapeutic, diagnostic, and imaging agents in a highly selective and effective manner.

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Development of novel self-assembled DS-PLGA hybrid nanoparticles for improving oral bioavailability of vincristine sulfate by P-gp inhibition

Cited by 122 publications

References 36 publications

A novel approach in mucoadhesive drug delivery system to improve zidovudine intestinal permeability

A novel approach in mucoadhesive drug delivery system to improve zidovudine intestinal permeability

Synergistic and complete reversal of the multidrug resistance of mitoxantrone hydrochloride by three-in-one multifunctional lipid-sodium glycocholate nanocarriers based on simultaneous BCRP and Bcl-2 inhibition

Concepts and practices used to develop functional PLGA-based nanoparticulate systems

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