Development of novel porous nasal scaffold using injection molding

Abstract

Porous scaffolds fabricated from biodegradable polymers have been widely used and play a vital role in tissue engineering and in situ tissue reconstruction. This study presents a novel fabrication technique involving injection molding and conventional particulate leaching (IM/PL) to obtain the L‐shaped nasal scaffold for rhinoplasty. The results indicate that the porous nasal scaffold made by the IM/PL method shows the acceptable biocompatibility and degradation. The nasal scaffold may degrade well after surgery and the cartilage tissue may grow well in it. This IM/PL technique may replace the traditional artificial silicone filler and reduce the surgery cost. POLYM. ENG. SCI. 2013. © 2012 Society of Plastics Engineers

Fabrication of porous synthetic polymer scaffolds for tissue engineering

“…Teng et al fabricated L-shaped nasal scaffolds using injection molding combined with salt leaching. 112 Ghosh et al prepared PLLA/PEO blends using injection molding, where the PEO phase was leached out to a create porous scaffold. 113 Gas foaming.…”

The effect of foaming process with supercritical CO2 on the morphology and properties of 3D porous polylactic acid scaffolds

“…[ 2 ] The polymer matrix of the scaffolds could also be used for the release, in precisely calculated rates, of growth factors and drugs used in biotechnology. [ 3 ] According to Teng et al, [ 4 ] porous scaffolds can be fabricated via solvent casting/particulate leaching with low reproducibility, high porosity but poor pore connectivity, rapid prototyping with high reproducibility, good pore connectivity but low porosity and emulsion freeze drying with low reproducibility, high porosity, and good pore connectivity. However, these fabrication techniques involve the use of organic solvents.…”