Development of novel paper based electrochemical immunosensor with self-made gold nanoparticle ink and quinone derivate for highly sensitive carcinoembryonic antigen

Pavithra, M.; Muruganand, S.; Parthiban, C.

doi:10.1016/j.snb.2017.10.177

Cited by 49 publications

(21 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These potential problems might be costly in resource deprived settings. Wax printing has emerged as a means to fabricate robust hydrophobic patterns for electrochemical devices on paper substrates 23–25 . Although paper substrates are inexpensive they lack tear toughness that might be required under certain environmental conditions.…”

Section: Introductionmentioning

confidence: 99%

Hand-Fabricated CNT/AgNPs Electrodes using Wax-on-Plastic Platforms for Electro-Immunosensing Application

Chen

Qamar

Asefifeyzabadi

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Fabrication of inexpensive and flexible electronic and electrochemical sensors is in high demand for a wide range of biochemical and biomedical applications. We explore hand fabrication of CNT modified AgNPs electrodes using wax-on-plastic platforms and their application in electrochemical immunosensing. Wax patterns were printed on polyethylene terephthalate-based substrates to laydown templates for the electrodes. Hand painting was employed to fabricate a silver conductive layer using AgNPs ink applied in the hydrophilic regions of the substrate surrounded by wax. CNT was drop cast on top of the working electrodes to improve their electrochemical signal. The device layers were characterized by scanning electron microscopy. The electrochemical performance of the hand fabricated AgNPs and CNT/AgNPs electrodes was tested using cyclic voltammetry, differential pulse voltammetry, and amperometry. The electrochemical response of CNT/AgNPs electrodes was relatively faster, higher, and more selective than unmodified AgNPs sensing electrodes. Finally, the hand-painted CNT/AgNPs electrodes were applied to detect carcinoembryonic antigen (CEA) by measuring the end-product of immunoassay performed on magnetic particles. The detection limit for CEA was found to be 0.46 ng/mL.

show abstract

Section: Introductionmentioning

confidence: 99%

Hand-Fabricated CNT/AgNPs Electrodes using Wax-on-Plastic Platforms for Electro-Immunosensing Application

Chen

Qamar

Asefifeyzabadi

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In this context, the special features of paper as support material for the preparation of diagnostic devices, together with those of screen-printed platforms, represents an important advance for easy self-testing and point-of-care (POC) assessment. Table 2 summarizes the analytical characteristics and the main properties of some recent and representative methods applied to analytes of clinical interest in biological samples [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. Some selected examples are discussed below.…”

Section: Screen-printed Paper Electrochemical (Bio)sensorsmentioning

confidence: 99%

“…Oher configurations involving label-free paper-based immunosensors with immobilized capture antibodies have been reported for the detection of hormones [ 40 , 42 ], CRP [ 43 ], interferon (IFN-γ) [ 45 ], cancer biomarkers [ 44 , 46 ], and cardiac biomarkers [ 41 , 47 ]. Among them, it is worth mentioning the platform described by Ruecha et al [ 45 ] involving a paper-based microfluidic device coupled with a label-free electrochemical impedimetric immunosensor for the detection of IFN-γ in serum.…”

Section: Screen-printed Paper Electrochemical (Bio)sensorsmentioning

confidence: 99%

Screen-Printed Electrodes: Promising Paper and Wearable Transducers for (Bio)Sensing

2020

View full text Add to dashboard Cite

Screen-printing technology has revolutionized many fields, including that of electrochemical biosensing. Due to their current relevance, this review, unlike other papers, discusses the relevant aspects of electrochemical biosensors manufactured using this technology in connection to both paper substrates and wearable formats. The main trends, advances, and opportunities provided by these types of devices, with particular attention to the environmental and biomedical fields, are addressed along with illustrative fundamentals and applications of selected representative approaches from the recent literature. The main challenges and future directions to tackle in this research area are also pointed out.

show abstract

“…We have previously developed an electrochemical immunochromatography platform as a µPAD [ 16 , 17 ]. Usually, electrodes are printed on a paper when an electrochemical method is introduced into µPADs [ 9 , 18 , 19 ]. In such a case, the electrodes would be disposed of along with the paper, thus making it costly.…”

Section: Introductionmentioning

confidence: 99%

A Simple, Low Cost, Sensitive, and Portable Electrochemical Immunochromatography Sensing Device to Measure Estrone-3-Sulfate

Iwasaki

Kataoka²,

Sawadaishi³

et al. 2020

Sensors

View full text Add to dashboard Cite

In livestock production, point-of-care testing (POCT) technology that enables easy on-site analysis of sex hormones is desired to improve reproductive efficiency. In this context, low-molecular-weight endogenous steroids are particularly important for perinatal management. Therefore, we attempted to use a simple method that combines electrochemical techniques with immunochromatography to measure estrone-3-sulfate (E1S), one of the low-molecular-weight endogenous steroids that is an estrogen ester. The limit of detection (LOD) for E1S achieved by electrochemical immunochromatography was 570.5 ng/mL, which was one to two orders of magnitude lower than that of small molecule compounds analyzed by other POCT techniques (Primpray et al., Anal. Chim. Acta, 2019). In addition, it was indicated by a colorimetric analysis that the sensitivity of the electrochemical immunochromatographic technique could be enhanced by improving the method of application of the antibodies on the nitrocellulose membrane and the contact between the electrochemical detector and the nitrocellulose membrane.

show abstract

Development of novel paper based electrochemical immunosensor with self-made gold nanoparticle ink and quinone derivate for highly sensitive carcinoembryonic antigen

Cited by 49 publications

References 48 publications

Hand-Fabricated CNT/AgNPs Electrodes using Wax-on-Plastic Platforms for Electro-Immunosensing Application

Hand-Fabricated CNT/AgNPs Electrodes using Wax-on-Plastic Platforms for Electro-Immunosensing Application

Screen-Printed Electrodes: Promising Paper and Wearable Transducers for (Bio)Sensing

A Simple, Low Cost, Sensitive, and Portable Electrochemical Immunochromatography Sensing Device to Measure Estrone-3-Sulfate

Contact Info

Product

Resources

About