Development of Novel Functional Molecules Targeting DNA and RNA

Sasaki, Shigeki

doi:10.1248/cpb.c19-00169

Cited by 6 publications

(1 citation statement)

References 79 publications

(79 reference statements)

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“…RNA and DNA are targets for modulating gene expression. Currently, advancements in molecular biology can allow them to be used as excellent therapeutic targets in multiple pathologies [ 235 ]. For example, the modulation of antioxidant enzymes using gene therapy has been useful in oxidative stress if a specific target receptor is already known [ 236 ].…”

Section: Ischemia-reperfusion Antioxidant Pharmacodynamicsmentioning

confidence: 99%

Therapeutic Targets for Regulating Oxidative Damage Induced by Ischemia-Reperfusion Injury: A Study from a Pharmacological Perspective

Rangel

García-Valdés

Villar

et al. 2022

Oxidative Medicine and Cellular Longevity

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Ischemia-reperfusion (I-R) injury is damage caused by restoring blood flow into ischemic tissues or organs. This complex and characteristic lesion accelerates cell death induced by signaling pathways such as apoptosis, necrosis, and even ferroptosis. In addition to the direct association between I-R and the release of reactive oxygen species and reactive nitrogen species, it is involved in developing mitochondrial oxidative damage. Thus, its mechanism plays a critical role via reactive species scavenging, calcium overload modulation, electron transport chain blocking, mitochondrial permeability transition pore activation, or noncoding RNA transcription. Other receptors and molecules reduce tissue and organ damage caused by this pathology and other related diseases. These molecular targets have been gradually discovered and have essential roles in I-R resolution. Therefore, the current study is aimed at highlighting the importance of these discoveries. In this review, we inquire about the oxidative damage receptors that are relevant to reducing the damage induced by oxidative stress associated with I-R. Several complications on surgical techniques and pathology interventions do not mitigate the damage caused by I-R. Nevertheless, these therapies developed using alternative targets could work as coadjuvants in tissue transplants or I-R-related pathologies

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Section: Ischemia-reperfusion Antioxidant Pharmacodynamicsmentioning

confidence: 99%