Development of novel flexible sugar ester vesicles as carrier systems for the antioxidant enzyme catalase for wound healing applications

Abdel-Mageed, Heidi M.; El-Laithy, Hanan M.; Mahran, Laila; Fahmy, Afaf S.; Mäder, Karsten; Mohamed, Saleh A.

doi:10.1016/j.procbio.2012.04.008

Cited by 34 publications

(22 citation statements)

References 30 publications

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“…As sucrose contains eight hydroxyl groups, compounds ranging from sucrose monoesters to octaesters can be produced. These esters contain different fatty acids (stearic, palmitic, myristic and lauric acid) in different ratios (37). The type of fatty acid and the degree of esterification determines the hydrophilic lipophilic balance (HLB) value and the melting point of these materials.…”

Section: Surfactantsmentioning

confidence: 99%

Recent advances in non-ionic surfactant vesicles (niosomes): Fabrication, characterization, pharmaceutical and cosmetic applications

Chen

Hanning

Falconer

et al. 2019

European Journal of Pharmaceutics and Biopharmaceutics

286

176

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Surfactantsmentioning

confidence: 99%

Recent advances in non-ionic surfactant vesicles (niosomes): Fabrication, characterization, pharmaceutical and cosmetic applications

Chen

Hanning

Falconer

et al. 2019

European Journal of Pharmaceutics and Biopharmaceutics

286

176

View full text Add to dashboard Cite

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“…At predetermined intervals, the samples are exposed to the same proportion of freshly prepared medium. We then analyze the samples using the appropriate methods to assess the volume of the drug released over time [95,102,103]. Another method of studying in vitro drug release is the Franz diffusion cell.…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Niosomes: A Novel Targeted Drug Delivery System

Akbarzadeh¹,

Sedaghatnia²,

Bourbour³

et al. 2021

Preprint

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Nanotechnology is making significant transformation to our world, especially in healthcare and the treatment of diseases. It is widely used in different medical applications, such as in treatment and detection. Targeting diseased cell with nanomedicines is one of the numerous applications of nanotechnology. Targeted drug delivery systems for delivering various types of drugs to specific sites are such a dynamic area in pharmaceutical biotechnology and nanotechnology. Compared to conventional drugs, nanomedicines have a higher absorption and bioavailability rate, improving efficacy and minimizing side effects. There are several drug delivery systems including metallic nanoparticles, polymers, liposomes, and microspheres, but one of the most important is the niosomes, which are produced by nonionic surfactants. Because of the amphiphilic nature and structure, hydrophilic or hydrophobic drugs can be loaded into niosome structures. Other compounds, including cholesterol, can also be applied to the niosomes' backbone to rigidize the structure. Several variables such as the type of surfactant in niosome production, the preparation method, and the hydration temperature can affect the structure of the niosomes. Nevertheless, in-silico design of drug delivery formulations requires molecular dynamic simulation tools, molecular docking, and ADME (absorption; distribution; excretion; metabolism) properties, which evaluate physicochemical features of formulation and ADME attitudes before synthesis, investigating the interaction between nano-carriers and specific targets. Hence, experimenting in-vitro and in-vivo is essential. In this review, the basic aspects of niosomes are described including their structure, characterization, preparation methods, optimization with in-silico tools, factors affecting their formation, and limitations.

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“…Non-ionic sugar ester nanovesicles are used as a biocompatible material for encapsulation of catalase (Abdel-Mageed et al 2012). This approach of encapsulation makes catalase more stable at acidic pH and protects catalase from trypsin digestion.…”

Section: Textile Bleachingmentioning

confidence: 99%

“…This approach of encapsulation makes catalase more stable at acidic pH and protects catalase from trypsin digestion. Such formulation of catalase is important for topical administration aiming at faster wound healing and has been demonstrated by an in vivo study which was carried out on rats (Abdel-Mageed et al 2012).…”

Section: Textile Bleachingmentioning

confidence: 99%

Catalases as biocatalysts in technical applications: current state and perspectives

Lončar

Fraaije

2015

Appl Microbiol Biotechnol

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Catalases represent a class of enzymes which has found its place among industrially relevant biocatalysts due to their exceptional catalytic rate and high stability. Textile bleaching prior to the dyeing process is the main application and has been performed on a large scale for the past few decades. Their limited substrate scope has not prevented the development of various other catalase-based applications. Newly developed approaches continue to exploit their excellent catalytic potential to degrade hydrogen peroxide while (per)oxidase activity of catalases is opening a new range of possibilities as well. This review provides an overview of applications that involve heme-containing catalases that have been demonstrated in recent years.

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Development of novel flexible sugar ester vesicles as carrier systems for the antioxidant enzyme catalase for wound healing applications

Cited by 34 publications

References 30 publications

Recent advances in non-ionic surfactant vesicles (niosomes): Fabrication, characterization, pharmaceutical and cosmetic applications

Recent advances in non-ionic surfactant vesicles (niosomes): Fabrication, characterization, pharmaceutical and cosmetic applications

Niosomes: A Novel Targeted Drug Delivery System

Catalases as biocatalysts in technical applications: current state and perspectives

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