Development of novel bone targeting peptide–drug conjugate of 13-aminomethyl-15-thiomatrine for osteoporosis therapy

Song, Jia; Liu, Chao; Bai, Haohao; Cong, Wei; Tang, Hua; Hu, Honggang; Su, Li; He, Shipeng; Wang, Yong

doi:10.1039/d1ra08136e

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…Collagen gel containing HAP is selected to mimic the natural environment of bone for the progression of breast cancer cells. [ 17,18 ] The results showed that the liposome PTX‐Glu6 5 ‐Lip group could distinctly suppress the cytostatic activity of MDA‐MB‐231 cells, indicating the precedence of Glu6 5 functionalization for the treatment of bone metastasis compared with other groups (Figure 2d).…”

Section: Resultsmentioning

confidence: 98%

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Liposomes modified with a multivalent glutamic hexapeptide: A novel and effective way to promote bone targeting

Zhao,

Yang,

Cui

et al. 2023

Archiv der Pharmazie

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It is well known that bone‐related diseases are difficult to treat due to the relatively low blood flow. Therefore, targeting the delivery of drugs to bone may not only improve the therapeutic effect but also reduce the dose. To prepare liposomes, a series of novel multivalent glutamic hexapeptide derivatives were designed and synthesized as liposome ligands, which can effectively deliver paclitaxel (PTX) to bone. The liposomes were prepared and their encapsulation efficiency, particle size, stability, zeta potential, hemolysis, and release behavior were characterized. The results indicated that the coated liposomes, PTX‐Glu61‐Lip, PTX‐Glu62‐Lip, PTX‐Glu63‐Lip, and PTX‐Glu65‐Lip, showed remarkable bone‐targeting activity. Compared with the other coated liposomes, PTX‐Glu65‐Lip showed prominent targeting ability and anti‐bone metastasis activity on the basis of in vitro and in vivo evaluations. Our study may contribute to the field of design of bone‐targeting drugs.

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Section: Resultsmentioning

confidence: 98%

“…Collagen gel containing HAP is selected to mimic the natural environment of bone for the progression of breast cancer cells. [17,18] The results…”

Section: Hap Binding Assaymentioning

confidence: 99%