Development of New Evaluation Method for Whitening Agents by Using the Effect of .ALPHA.-MSH or Endothelin-1 on Normal Melanocytes.

Ochiai, Yasunobu; Torii, Kousuke; Okano, Yuri; Hashimoto, Masaki

doi:10.5107/sccj.34.47

Cited by 1 publication

(2 citation statements)

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“…UV‐B‐exposed keratinocytes produce cytokines and upregulate secretion of endothelin‐1 (ET‐1) and α‐melanocyte‐stimulating hormone (α‐MSH), both of which promote induction of tyrosinase, the rate‐limiting enzyme catalysing melanin synthesis, in melanocytes. Therefore, inhibition of ET‐1 or α‐MSH secretion by keratinocytes and/or tyrosinase induction in melanocytes could prevent melanin production in the latter following UV‐B exposure …”

Section: Introductionmentioning

confidence: 99%

“…Therefore, inhibition of ET-1 or α-MSH secretion by keratinocytes and/ or tyrosinase induction in melanocytes could prevent melanin production in the latter following UV-B exposure. [4] Angiopoietin-like protein 2 (ANGPTL2) is a secreted protein that induces inflammation in various cell types via autocrine or paracrine signals. [5] ANGPTL2 upregulation exacerbates various diseases, such as cardiovascular disease, diabetes or cancer by enhancing inflammation.…”

Section: Introductionmentioning

confidence: 99%

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UV‐B‐activated B16 melanoma cells or HaCaT keratinocytes accelerate signaling pathways associated with melanogenesis via ANGPTL 2 induction, an activity antagonized by Chrysanthemum extract

Satou¹,

Maji²,

Isamoto³

et al. 2019

Experimental Dermatology

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Sunburn causes inflammation, which increases melanin production in skin and causes hyperpigmentation. Angiopoietin‐like protein (ANGPTL) 2 is an inflammatory mediator induced in sun‐exposed skin areas. However, whether ANGPTL2 functions in melanin production remains unclear. To assess this possibility, we overexpressed Angptl2 in the melanoma line B16 and in the keratinocyte line HaCaT. Relative to controls, Angptl2‐expressing B16 cells produced higher melanin levels via tyrosinase induction. Accordingly, Angptl2‐expressing HaCaT cells secreted relatively high levels of both endothelin‐1 (ET‐1) and α‐melanocyte‐stimulating hormone (α‐MSH). Moreover, treatment with an extract from Chrysanthemum indicum × Erigeron annuus (CE) suppressed ANGPTL2 expression and repressed tyrosinase induction in melanocytes and of α‐MSH and ET‐1 in keratinocytes. Our data suggest that ANGPTL2 expression in keratinocytes and melanin‐producing cells accelerates pigment production and that treatment of skin with a CE extract could prevent melanin accumulation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%