Development of new drug delivery system based on ordered mesoporous carbons: characterisation and cytocompatibility studies

Karavasili, Christina; Amanatiadou, Elsa P.; Sygellou, L.; Giasafaki, Dimitra; Steriotis, Theodore; Charalambopoulou, Georgia; Vizirianakis, Ioannis S.; Fatouros, Dimitrios G.

doi:10.1039/c3tb20304b

Cited by 39 publications

(38 citation statements)

References 34 publications

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“…However, mesoporous silicas have some drawbacks as their weak stability under extreme pH conditions or the fact that long-term exposure to silica compounds can exert a cytotoxic effect and weaken the immune system [19,20]. Ordered mesoporous carbons (OMCs) overcome the drawbacks of these materials and emerge as highly valuable drug delivery systems because of their well-ordered and tunable pore structure, high pore volumes and specific surface areas, high stability in aqueous media and excellent biocompatibility [21,22]. The surface chemistry of materials used as drug carriers is a key factor in adsorption and release of drugs.…”

Section: Introductionmentioning

confidence: 99%

pH-responsive ordered mesoporous carbons for controlled ibuprofen release

Sánchez-Sánchez

Suárez-Garcı́a

Martı́nez-Alonso

et al. 2015

Carbon

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Section: Introductionmentioning

confidence: 99%

pH-responsive ordered mesoporous carbons for controlled ibuprofen release

Sánchez-Sánchez

Suárez-Garcı́a

Martı́nez-Alonso

et al. 2015

Carbon

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“…Morphology and Structure of the Pristine and Silver-Doped Mesoporous Carbons SEM analysis of the silver-doped C3 samples (Figure 1) revealed on one hand that they exhibit the typical elongated morphology of CMK-3 carbons 24 with mean diameter of 200-300 nm and length around 0.5-1 μm and on the other that Ag nanoparticles (with an average size of 25 nm) are highly dispersed on the carbonaceous surface with only very few aggregates.…”

Section: Resultsmentioning

confidence: 99%

<p>Silver Decorated Mesoporous Carbons for the Treatment of Acute and Chronic Wounds, in a Tissue Regeneration Context</p>

Torre¹,

Giasafaki²,

Steriotis³

et al. 2019

IJN

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Introduction: Silver decorated mesoporous carbons are interesting systems that may offer effective solutions for advanced wound care products by combining the well-known antimicrobial activity of silver nanoparticles with the versatile properties of ordered mesoporous carbons. Silver is being used as a topical antimicrobial agent, especially in wound repair. However, while silver shows bactericidal properties, it is also cytotoxic at high concentrations. Therefore, the incorporation of silver into ordered mesoporous carbons allows to exploit both silver's biological effects and mesoporous carbons' biocompatibility and versatility with the purpose of conceiving silver-doped materials in light of the growing health concern in wound care. Methods: The wound healing potential of an ordered mesoporous carbon also doped with two different loadings of silver nanoparticles (2 wt% and 10 wt%), was investigated through a biological assessment study based on different assays (cell viability, inflammation, antibacterial tests, macrophage-conditioned fibroblast and human keratinocyte cell cultures). Results: The results show silver-doped ordered mesoporous carbons to positively condition cell viability, with a cell viability percentage >70% even for 10 wt% Ag, to modulate the expression of inflammatory cytokines and of genes involved in tissue repair (KRT6a, VEGFA, IVN) and remodeling (MMP9, TIMP3) in different cell systems. Furthermore, along with the biocompatibility and the bioactivity, the silver-doped ordered mesoporous carbons still retain an antibacterial effect, as shown by a maximum of 13.1% of inhibited area in the Halo test. The obtained results clearly showed that the silver-doped ordered mesoporous carbons exhibit both good biocompatibility and antibacterial effect with enhanced re-epithelialization, angiogenesis promotion and tissue regeneration. Discussion: These findings suggest that the exceptional properties of silver-doped ordered mesoporous carbons could be exploited in the treatment of acute and chronic wounds and that such carbon materials could be potential candidates for use in medical devices for wound healing purposes, in particular, the 10 wt% loading, as the results showed to be the most effective.

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“…Whilst the majority of studies into safety and biocompatibility of novel materials for drug delivery focus on parenteral administration, the importance of also verifying oral safety is increasingly being recognized. For mesoporous carbon, several studies have also investigated in vitro and/or in vivo biocompatibility alongside important proof-of-concept oral pharmacokinetic studies (50,55,74,(103)(104)(105). For example, Niu et al examined the potential irritant effects of mesoporous carbon on the GIT, by undertaking a gastric mucosa irritation test (50).…”

Section: Safety Assessment and Toxicity Concernsmentioning

confidence: 99%

Novel Nanostructured Solid Materials for Modulating Oral Drug Delivery from Solid-State Lipid-Based Drug Delivery Systems

Dening

Rao

Thomas

et al. 2015

AAPS J

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Lipid-based drug delivery systems (LBDDS) have gained significant attention in recent times, owing to their ability to overcome the challenges limiting the oral delivery of poorly water-soluble drugs. Despite the successful commercialization of several LBDDS products over the years, a large discrepancy exists between the number of poorly water-soluble drugs displaying suboptimal in vivo performances and the application of LBDDS to mitigate their various delivery challenges. Conventional LBDDS, including lipid solutions and suspensions, emulsions, and self-emulsifying formulations, suffer from various drawbacks limiting their widespread use and commercialization. Accordingly, solid-state LBDDS, fabricated by adsorbing LBDDS onto a chemically inert solid carrier material, have attracted substantial interest as a viable means of stabilizing LBDDS whilst eliminating some of the various limitations. This review describes the impact of solid carrier choice on LBDDS performance and highlights the importance of appropriate solid carrier material selection when designing hybrid solid-state LBDDS. Specifically, emphasis is placed on discussing the ability of the specific solid carrier to modulate drug release, control lipase action and lipid digestion, and enhance biopharmaceutical performance above the original liquid-state LBDDS. To encourage the interested reader to consider their solid carrier choice on a higher level, various novel materials with the potential for future use as solid carriers for LBDDS are described. This review is highly significant in guiding future research directions in the solid-state LBDDS field and fostering the translation of these delivery systems to the pharmaceutical marketplace.

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Development of new drug delivery system based on ordered mesoporous carbons: characterisation and cytocompatibility studies

Cited by 39 publications

References 34 publications

pH-responsive ordered mesoporous carbons for controlled ibuprofen release

pH-responsive ordered mesoporous carbons for controlled ibuprofen release

<p>Silver Decorated Mesoporous Carbons for the Treatment of Acute and Chronic Wounds, in a Tissue Regeneration Context</p>

Novel Nanostructured Solid Materials for Modulating Oral Drug Delivery from Solid-State Lipid-Based Drug Delivery Systems

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