Development of New Babassu Oil Lipidic Nanostructured Systems; Potential Alternative for Benign Prostatic Hyperplasia Therapy

Amaral, Lilian; Barros, Rita de Cassia Ascencao; Barbosa, Samantha Soares; Abreu, Letícia Coli Louvisse de; Carmo, Flávia Almada do; Castro, Helena Carla; Nasciutti, Luiz Eurico; Rodrigues, Carlos Rangel; Sousa, Valéria Pereira de; Cabral, Lúcio Mendes

doi:10.2174/1573413710666140806005930

Cited by 5 publications

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“…Copaiba exuded oleoresin is used as an anti-inflammatory, to healing wounds, as an urinary antiseptic, and to treat ulcer, bronchitis and cancer [8]. Pharmacological studies confirmed the antiinflammatory [8,10,13,18,26], antitumoral [12,27,28] and analgesic [12].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it has already been demonstrated that babassu nanosystems show activity on cell cultures derived from benign prostatic hyperplasia [17]. Babassu, in nanostructured systems, also reduce the viability of macrophage-like cell line and was not toxic to human colon epithelial cancer cell line indicating its potential use for the treatment of highly inflammatory processes and for oral administration [18]. Our group demonstrated that a nanocomposite containing copaiba oilresin induced morphological and behavioral changes in human endometriotic stromal cell cultures, with decrease of cell viability and proliferation and cell death induction [19].…”

Section: Introductionmentioning

confidence: 99%

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Copaiba Oilresin Exerts an Additive Effect to the Babassu Oil on Behavioral Changes in Human Endometriotic Cell Cultures

Silva¹,

Abreu²,

Ferrari³

et al. 2022

Preprint

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Background: Current drug for the treatment of endometriosis is not able of completely cure and significant side effects hinder the continuation of treatment. So, the search for new drug candidates is necessary, and the use of plants extracts is highlighted. Babassu oil and copaiba oilresin have several therapeutic properties. We investigated the in vitro effects of two nanoemulsions containing babassu oil (Orbignya speciosa) (SNEDDS-18) and/or copaiba oilresin (Copaifera langsdorffii) (SNEDDS-18/COPA) on cultured human eutopic endometrium stromal cells from endometrial biopsies of patients without (CESC) and with (EuESC) endometriosis, and human stromal cells from biopsies of endometriotic lesions (EctESC). Methods: CESC, EuESC and EctESC were established and treated with SNEDDS-18 and SNEDDS-18/COPA to evaluate its effects on cytotoxicity, cell morphology, proliferation, and signaling pathways. Results: After 48 hours incubation with SNEDDS-18 and SNEDDS-18/COPA, cell viability and proliferation were inhibited, especially in EctESC. The lowest concentration of both nanoemulsions reduced cell viability and proliferation and breakdown the cytoskeleton in EctESCs. After 24h treatment it was observed a decrease in IL-1, TNF-α, and MCP-1, and an increase in IL-10 production. Conclusions: Both nanoemulsions can affect the endometriotic stromal cell behaviors, thus revealing two potential candidates for new phytotherapeutic agents on the management of endometriosis.

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