Nanotechnology in phytotherapy

Falcão, Deborah Quintanilha; Oliveira, Adriana Passos; Lima, Bruno R.; Cardoso, Anne C.A.; Almeida, Kessiane B.; Santos, T.C.C.R.S.; Nascimento, Leonor M.; Desmarais, Glauce C.; Sanches, Paola S.; Araújo, Emeli Moura de; Mourão, Samanta Cardozo

doi:10.1016/b978-0-12-813687-4.00003-7

Cited by 4 publications

(1 citation statement)

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“…The use of colloidal carriers (in the micro- or nano-scale size range) is reported to enable the delivery of drugs to their specific sites of action with high efficiency, while also displaying significantly less cytotoxicity than cantharidin, causing cell deaths of about 15% and 38% at 24 and 48 h of treatment, respectively, because lower initial concentrations are needed [ 29 ]. The encapsulation of herbal extracts or isolated compounds in colloidal formulations has been reported to enhance their diffusion through different biological membranes [ 30 ], leading to improvements in their pharmacokinetics, release, and delivery to target sites [ 31 ]; providing protection from metabolic degradation; increasing their bioavailability; and hence diminishing the frequency of their administration [ 26 ].…”

Section: Limitations In Using Plant-derived Bioactive Molecules: the ...mentioning

confidence: 99%

Biopolymer- and Lipid-Based Carriers for the Delivery of Plant-Based Ingredients

2023

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Natural ingredients are gaining increasing attention from manufacturers following consumers’ concerns about the excessive use of synthetic ingredients. However, the use of natural extracts or molecules to achieve desirable qualities throughout the shelf life of foodstuff and, upon consumption, in the relevant biological environment is severely limited by their poor performance, especially with respect to solubility, stability against environmental conditions during product manufacturing, storage, and bioavailability upon consumption. Nanoencapsulation can be seen as an attractive approach with which to overcome these challenges. Among the different nanoencapsulation systems, lipids and biopolymer-based nanocarriers have emerged as the most effective ones because of their intrinsic low toxicity following their formulation with biocompatible and biodegradable materials. The present review aims to provide a survey of the recent advances in nanoscale carriers, formulated with biopolymers or lipids, for the encapsulation of natural compounds and plant extracts.

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