Development of New Antiherpetic Drugs Based on Plant Compounds

Allahverdiyev, Adil M.; Bağırova, Melahat; Yaman, Serkan; Çakır-Koç, Rabia; Abamor, Emrah Şefik; Ates, Sezen Canim; Baydar, Serap Yeşilkır; Elcicek, Serhat; Oztel, Olga Nehir

doi:10.1016/b978-0-12-398539-2.00017-3

Cited by 27 publications

(15 citation statements)

References 45 publications

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“…We found ALDH1A1 to be expressed very heterogeneously and non-uniformly within the tumor tissue of the HCC specimens. It is unknown whether these ALDH1A1-overexpressing cells are the equivalent of “ALDH-bright cells” [ 34 ]. ALDH bright cells can be detected with ALDEFLUOR reagent by using flow cytometry or fluorescent microscopy.…”

Section: Discussionmentioning

confidence: 99%

ALDH1A1-overexpressing cells are differentiated cells but not cancer stem or progenitor cells in human hepatocellular carcinoma

et al. 2015

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Aldehyde dehydrogenase 1A1 (ALDH1A1) is considered to be a cancer stem cell marker in several human malignancies. However, the role of ALDH1A1 in hepatocellular carcinoma (HCC) has not been well elucidated. In this study, we investigated the relationship between ALDH1A1 and clinicopathological findings and examined whether ALDH1A1 deserves to be a cancer stem cell marker in HCC. Sixty HCC samples obtained from surgical resection were collected for immunohistochemical (IHC) staining. Of these 60 samples, 47 samples of HCC tumorous and non-tumorous tissues were evaluated with qRT-PCR. There was no significant difference in the ALDH1A1-mRNA level between tumorous and non-tumorous tissues. Tumorous ALDH1A1-mRNA level had no relationship with the clinicopathological features. Immunoreactivity of ALDH1A1 was classified into two groups based on the percentage of ALDH1A1-overexpressing cells. The ALDH1A1-high group was significantly associated with low serum levels of α-fetoprotein, small tumor diameter, very little lymphovascular invasion, more differentiated pathology and good stage. The ALDH1A1-high group showed more favorable prognosis for recurrence-free survival. In double-staining IHC, ALDH1A1 was not co-expressed with BMI1, EpCAM, CD13, CD24, CD90 and CD133, which reported as cancer stem cell markers in HCC. In conclusion, ALDH1A1-overexpressing cells could appear to be differentiated cells rather than cancer stem cells in HCC.

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Section: Discussionmentioning

confidence: 99%

ALDH1A1-overexpressing cells are differentiated cells but not cancer stem or progenitor cells in human hepatocellular carcinoma

et al. 2015

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“…ALDH1A1 catalyzes the oxidation of retinal (retinaldehyde) to the corresponding retinoic acid (RA) [ 38 ], which – upon binding to retinoic acid receptors (RAR) and/or retinoid X receptors (RXR) – initiates downstream RA signaling. ALDH1A1-dependent generation of RA is important for growth and differentiation of normal and malignant cells [ 38 , 39 ], including normal hematopoietic stem cells [ 38 ]. In embryonic cancer/stem cells and induced pluripotent stem (iPS) cells, RA signaling has been linked to CIN, based on increased occurrence of micronuclei and decreased expression of survivin [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

NEK2 mediates ALDH1A1-dependent drug resistance in multiple myeloma

et al. 2014

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We reported previously that increased expression of aldehyde dehydrogenase 1 (ALDH1) in multiple myeloma (MM) is a marker of tumor-initiating cells (TICs) that is further associated with chromosomal instability (CIN). Here we demonstrate that member A1 of the ALDH1 family of proteins, ALDH1A1, is most abundantly expressed in myeloma. Enforced expression of ALDH1A1 in myeloma cells led to increased clonogenicity, tumor formation in mice, and resistance to myeloma drugs in vitro and in vivo. The mechanism underlying these phenotypes included the ALDH1A1-dependent activation of drug-efflux pump, ABCB1, and survival proteins, AKT and BCL2. Over expression of ALDH1A1 in myeloma cells led to increased mRNA and protein levels of NIMA-related kinase 2 (NEK2), whereas shRNA-mediated knock down of NEK2 decreased drug efflux pump activity and drug resistance. The activation of NEK2 in myeloma cells relied on the ALDH1A1-dependent generation of the retinoid X receptor α (RXRα) ligand, 9-cis retinoic acid (9CRA) – not the retinoic acid receptor α (RARα) ligand, all-trans retinoic acid (ATRA). These findings implicate the ALDH1A1-RXRα-NEK2 pathway in drug resistance and disease relapse in myeloma and suggest that specific inhibitors of ALDH1A1 are worthy of consideration for clinical development of new approaches to overcome drug resistance in myeloma.

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“…Besides, there are reports that the essential oil from the SA and its isolated compounds exhibited promising antiviral activity against the HSV-1 in the viral suspension tests (Astani et al, 2011). There are more studies which have been devoted to the development of drugs against herpes (7401H HSV1; Allahverdiyev et al, 2013), along with products such as vaginal gels to fight Candida species, although more significant studies need to be achieved in order to step into the clinical trial phases (Gafiţ{t\hskip-0.7ex\char "B8}anu et al, 2016) for these pharmaceutical formulations. Apart from these, a number of compounds have been isolated from different species of the genus Illicium and have been tested against different types of viruses which is summarized in Table 2.…”

Section: Pre-clinical and Clinical Studies On Bioactive Compounds Fmentioning

confidence: 99%

Star anise (Illicium verum): Chemical compounds, antiviral properties, and clinical relevance

Patra

Das

Bose³

et al. 2020

Phytotherapy Research

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Medicinal herbs are one of the imperative sources of drugs all over the world. Star anise (Illicium verum), an evergreen, medium-sized tree with star-shaped fruit, is an important herb with wide distribution throughout southwestern parts of the Asian continent. Besides its use as spice in culinary, star anise is one of the vital ingredients of the Chinese medicinal herbs and is widely known for its antiviral effects. It is also the source of the precursor molecule, shikimic acid, which is used in the manufacture of oseltamivir (Tamiflu ® ), an antiviral medication for influenza A and influenza B. Besides, several other molecules with numerous biological benefits including the antiviral effects have been reported from the same plant. Except the antiviral potential, star anise possesses a number of other potentials such as antioxidant, antimicrobial, antifungal, anthelmintic, insecticidal, secretolytic, antinociceptive, antiinflammatory, gastroprotective, sedative properties, expectorant and spasmolytic, and estrogenic effects. This review aimed to integrate the information on the customary attributes of the plant star anise with a specific prominence on its antiviral properties and the phytochemical constituents along with its clinical aptness. K E Y W O R D S antiviral, Illicium verum, oseltamivir, shikimic acid, star anise, Tamiflu

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Development of New Antiherpetic Drugs Based on Plant Compounds

Cited by 27 publications

References 45 publications

ALDH1A1-overexpressing cells are differentiated cells but not cancer stem or progenitor cells in human hepatocellular carcinoma

ALDH1A1-overexpressing cells are differentiated cells but not cancer stem or progenitor cells in human hepatocellular carcinoma

NEK2 mediates ALDH1A1-dependent drug resistance in multiple myeloma

Star anise (Illicium verum): Chemical compounds, antiviral properties, and clinical relevance

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