Development of Nephrolithiasis in Asymptomatic Hyperuricemia: A Cohort Study

Kim, Seolhye; Chang, Yoosoo; Yun, Kyung Eun; Jung, Hyun Suk; Lee, Soo-Jin; Shin, Hocheol; Ryu, Seungho

doi:10.1053/j.ajkd.2017.01.053

Cited by 63 publications

(50 citation statements)

References 38 publications

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“…Prolonged disease duration in PsA patients with chronic inflammatory diseases may promote the release of proinflammatory cytokines and tumor necrosis factor, which are positively associated with high uric acid level 23,24 . A recent large Korean cohort study showed that an increased serum uric acid was modestly and independently associated with increased risk of development of nephrolithiasis, after adjustment for hemostasis model assessment of insulin resistance and high-sensitivity CRP 25 . Additionally, a previous study confirmed the association between obesity (1 of the metabolic syndrome components) and HUC in psoriatic patients, which is in agreement with our results 8 .…”

Section: Discussionmentioning

confidence: 99%

Characteristic and Outcome of Psoriatic Arthritis Patients with Hyperuricemia

Aljohani

Polachek²,

Ye³

et al. 2017

J Rheumatol

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Section: Discussionmentioning

confidence: 99%

Characteristic and Outcome of Psoriatic Arthritis Patients with Hyperuricemia

Aljohani

Polachek²,

Ye³

et al. 2017

J Rheumatol

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“…Baseline and follow-up examinations were conducted at the clinics of Kangbuk Samsung Hospital Health Screening Center. Data on demographic characteristics, smoking status, alcohol consumption, physical activity, educational level, medical history, and medication use were collected by standardized, selfadministered questionnaires, as described previously (28,30). Medical conditions diagnosed by a physician, including H. pylori infection, were assessed via the same questionnaire.…”

Section: Data Collectionmentioning

confidence: 99%

“…Serum levels of fasting glucose, uric acid, total cholesterol, lowdensity lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and high-sensitivity C-reactive protein (hsCRP) were measured as described previously (28,30). Insulin resistance was assessed with the HOMA-IR equation: fasting blood insulin (uU/mL) Â fasting blood glucose (mmol/L) / 22.5.…”

Section: Data Collectionmentioning

confidence: 99%

Body Mass Index and Risk of Intestinal Metaplasia: A Cohort Study

Kim

Chang

Ahn

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: We examined the association between body mass index (BMI) and development of endoscopic intestinal metaplasia.Methods: This retrospective cohort study included 142,832 Korean adults free of endoscopic intestinal metaplasia and atrophic gastritis who underwent upper endoscopy at baseline and subsequent visits and were followed for up to 5 years. A parametric proportional hazards model was used to estimate the adjusted HR with 95% confidence interval (CI) for incident intestinal metaplasia.Results: In more than 444,719.1 person-years of follow-up, 2,281 participants developed endoscopic intestinal metaplasia (incidence rate, 5.1 per 1,000 person-years). Increased BMI categories were associated with increased risk of new-onset intestinal metaplasia in a dose-response manner. After adjustment for age, sex, center, year of screening exam, smoking status, alcohol intake, exercise, total calorie intake, history of diabetes and hypertension, and history of Helicobacter pylori infection, the multivariable adjusted HRs (95% CIs) for incident intestinal metaplasia comparing BMIs of <18.5, 23-24.9, 25.0-29.9, and >30 kg/m 2 with a BMI of 18.5-22.9 kg/m 2 were 0.84 (0.64-1.09), 1.03 (0.93-1.16), 1.07 (0.96-1.20), and 1.48 (1.20-1.83), respectively. These associations did not differ by clinically relevant subgroups. Risk of endoscopic atrophic gastritis also increased as the baseline BMI category increased.Conclusions: In a large cohort of Korean men and women, obesity was independently associated with increased incidence of endoscopic atrophic gastritis and intestinal metaplasia.Impact: Excessive adiposity appears to play a role in development of stomach precursor lesions of stomach cancer, requiring further studies to determine whether strategies to reduce obesity will also help reduce precancerous lesions and, in turn, gastric cancer. d Median (interquartile range). e Among 123,194 participants without missing value on hsCRP. f Among 112,418 participants with plausible estimated energy intake levels (within three standard deviations from the log-transformed mean energy intake).Kim et al.

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“…Higher serum uric acid levels in patients with renal stones and renal impairment in our study suggest the need of uric acid control and monitoring especially in those with long standing gout disease. Recently, Kim et al 22 also found increased risk of developing a new stone with increasing level of serum uric acid concentration among men with asymptomatic hyperuricemia. Although urinary uric acid concentration does not seem to be a risk factor for stone 23 , allopurinol reduces calcium oxalate stone recurrence among patients with isolated hyperuricosuria 24 .…”

Section: Discussionmentioning

confidence: 96%

Urinary Stones, Renal Cysts and Renal Impairment in Patients with Gout

Dhakad¹,

Singh²

2018

IJCMR

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Introduction: Urinary stones, renal cysts and renal failure are reported complications of gout. This study aimed to elucidate prevalence and relationship among them in gout patients. Material and Methods:In this prospective study, 107 patients with gout were included. Clinical assessment, BMI, comorbidities, dietary habits, urine microscopy, serum uric acid and renal functions were noted in all patients. Ultrasonography was used to detect urinary stones, renal cysts or any other abnormality in urinary system. Data was analysed using unpaired t test and Chi-square test. P value of <0.05 was considered statistically significant. Results:In gout patients urinary stones, renal cysts and impaired renal function were seen in 24.2% (26/107), 19.6% (21/107) and 28% (30/7) cases respectively. Serum uric acid level was significantly higher in those with impaired renal function. Occurrence of urinary stones was related to serum uric acid levels and duration of gout (p=0.038 and p < 0.0001). There was no association between renal stones and renal cysts (p=0.153). Presence of renal stones and duration of gout were associated with impaired renal function in gout patients (p=0.0011 and p=0.0006). Conclusions:Urinary stones and renal impairment are significant health problems in gout patients. Urinary stones and long standing disease are associated with renal impairment in gout.How to cite this article: Urmila Dhakad, Bhupendra Pal Singh. Urinary stones, renal cysts and renal impairment in patients with gout.

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Development of Nephrolithiasis in Asymptomatic Hyperuricemia: A Cohort Study

Cited by 63 publications

References 38 publications

Characteristic and Outcome of Psoriatic Arthritis Patients with Hyperuricemia

Characteristic and Outcome of Psoriatic Arthritis Patients with Hyperuricemia

Body Mass Index and Risk of Intestinal Metaplasia: A Cohort Study

Urinary Stones, Renal Cysts and Renal Impairment in Patients with Gout

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