Development of natural-based wound dressings impregnated with bioactive compounds and using supercritical carbon dioxide

Dias, Ana M.A.; Braga, Mara E.M.; Seabra, Inês J.; Ferreira, Paula; Gil, M.H.; Sousa, Hermínio C. de

doi:10.1016/j.ijpharm.2011.01.063

Cited by 162 publications

(95 citation statements)

References 72 publications

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“…It was also concluded that the low compatibility between QU and the release medium (water) reduced the extent of release considerably (López-de-Dicastillo, Alonso, Catalá, Gavara, & Hernández-Muñoz, 2010; López-de-Dicastillo, Gómez-Estaca, Catalá, Gavara, & Hernández-Muñoz, 2012). On the other hand, the release of QU has been observed into water and physiological saline (Dias et al, 2011;Li et al, 2014). According to another study the release of QU (into 95% ethanol) depends on the hydrophobicity of polymers.…”

Section: In Vitro Release Studymentioning

confidence: 99%

Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: Slow release and high solubility

et al. 2016

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a b s t r a c tElectrospinning of polyacrylic acid (PAA) nanofibres (NF) incorporating b-cyclodextrin inclusion complex (b-CD-IC) of quercetin (QU) was performed. Here, b-CD was used as not only the crosslinking agent for PAA nanofibres but also as a host molecule for inclusion of QU. The phase solubility test showed enhanced solubility of QU due to the inclusion complexation; in addition, the stoichiometry of QU/b-CD-IC was determined to be 1:1. Computational modelling studies confirmed that 1:1 and 1:2 complex formation are desirable; 1:1 complex formation was chosen to have higher weight loading of QU. SEM images showed that PAA/QU/b-CD-IC-NF were bead-free and uniform. XRD indicated that PAA/QU/b-CD-IC-NF were amorphous in nature without the crystalline peaks of QU. Comparative results revealed that the release profile of QU from PAA/QU/b-CD-IC-NF was much slower but greater in total than from PAA/QU/b-CD-IC-film. Moreover, high antioxidant activity and photostability of QU was achieved in PAA/QU/b-CD-IC-NF.

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Section: In Vitro Release Studymentioning

confidence: 99%

Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: Slow release and high solubility

et al. 2016

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“…Reportedly, supercritical carbon dioxide (scCO 2 ) can be used to load polymeric carriers with antimicrobial substances [2][3][4][5][6][7][8][9][10][11][12], vitamins [13], drugs [14,15], dyes [16,17], and so on. There are two distinctive mechanisms of SSI.…”

Section: Introductionmentioning

confidence: 99%

Cellulose Acetate Based Material with Antibacterial Properties Created by Supercritical Solvent Impregnation

Milovanović

Adamović

Aksentijević

et al. 2017

International Journal of Polymer Science

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Supercritical CO 2 was used as a green solvent and impregnation medium for loading cellulose acetate beads with carvacrol in order to obtain a biomaterial with antibacterial properties. Supercritical solvent impregnation was performed in a high-pressure view cell at temperature of 50 ∘ C and pressures of 10, 21, and 30 MPa with the processing time ranging from 2 to 18 h. The rate of impregnation increased with the pressure increase. However, maximum impregnation yield (round 60%) was not affected by the pressure applied. Selected samples of the impregnated cellulose acetate containing 6-60% of carvacrol were proven to have considerable antibacterial effect against Gram-positive and Gram-negative bacterial strains including methicillin-resistant Staphylococcus aureus which causes severe infections in humans and animals. In addition, cellulose acetate beads containing 6.0-33.6% of carvacrol were shown to have a porous structure with submicron pores which is of interest for the controlled delivery applications.

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“…Carboxybutylchitosan and agarose based films and foam type wound dressings loaded with quercetin and thymol as anti-inflammatory and anaesthetic respectively have been prepared using supercritical solvent impregnation by means of supercritical carbon dioxide [251]. The formulations were characterised for sustained release and fluid handling characteristics.…”

Section: Polysaccharide-based Wound Delivery Systemsmentioning

confidence: 99%

“…These include thiolated chitosan [35,36,37], carboxybutylchitosan [251], thiolated pectin, [258,259] and caboxymethyl xanthan [260,261,262]. The reader is referred to the references provided for more in depth evaluation of the unique characteristics of these chemically modified natural polysaccharides and their use as drug delivery systems for drug delivery across the various mucosal routes as discussed above.…”

Section: Chemically Modified Polysaccharide Polymersmentioning

confidence: 99%

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

Boateng

Okeke²,

Khan³

2015

CPD

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There has been increased interest in novel drug delivery systems to be administered via mucosal routes as an alternative to the currently used traditional routes such as parenteral (injections) and oral routes of administration. This is due to the several advantages they offer including avoiding first pass metabolism in the liver for oral administration and local activity which avoids the need for high systemic doses. To achieve the foregoing objectives, bioadhesive vehicles are required that ensure prolonged residence time to achieve systemic bioavailability via substantial drug absorption or significant drug concentration for local action.The drug delivery system is also required to be non-deleterious to the site of application and be well tolerated by vulnerable groups such as paediatric and geriatric patients. These essential characteristics are mainly satisfied by naturally occurring polymers, including polysaccharide based polymers which have the advantage of biocompatibility, biodegradability and therefore safety. This review discusses various bioadhesive polymers of polysaccharide origin formulated into a variety of dosage forms for drug delivery via the body's mucosal (moist) surfaces including ocular, oral (buccal and sublingual), nasal, gastrointestinal and vaginal mucosa, as well as moist wound sites. The anatomy and / or physiology of each site, coupled with the unique challenges each poses, the strategies employed for ensuring therapeutic efficacy, as well as the current state of the art will also be covered.

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Development of natural-based wound dressings impregnated with bioactive compounds and using supercritical carbon dioxide

Cited by 162 publications

References 72 publications

Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: Slow release and high solubility

Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: Slow release and high solubility

Cellulose Acetate Based Material with Antibacterial Properties Created by Supercritical Solvent Impregnation

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

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