Development of nanostructured lipid carrier (NLC) assisted with polysorbate nonionic surfactants as a carrier for l-ascorbic acid and Gold Tri.E 30

Suk, Vicit Rizal Eh; Latif, Farhanim Mohd; Teo, Yin Yin; Misran, Misni

doi:10.1007/s13197-020-04357-x

Cited by 21 publications

(9 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lipids arrangements on the surface of the nanoparticle, surfactant surface charge, and the charge of the encapsulated drug interfere with ZP. 24 From the measurement of zeta potential, unluckily, tween 80 gave a less negative charge value, which might explain the tendency of the prepared NLC to agglomeration after a small period of production, an interesting story claimed that NLC system using a steric stabilizer does not need a high value of ZP to maintain their stability during the storage period, this result is similar to that obtained by Eh Suk et al 25 Likewise, lecithin showed to impart a more negative charge of the formulated RNB-NLC resulting in an increment in the ZP with statistical significance (p < 0.05), this might also be linked to the existence of hydroxyl and hence boosts the stability of the nanodispersion system, a similar outcome was obtained by Czajkowska. 26…”

Section: Effect Of Zeta Potential (Zp)supporting

confidence: 74%

Preparation and Evaluation of Rizatriptan Benzoate Loaded Nanostructured Lipid Carrier Using Diff erent Surfactant/Co-Surfactant Systems

Rajab¹,

Jawad²

2023

IJDDT

View full text Add to dashboard Cite

Migraine is the second most common neurological illness, aff ecting around one billion people each year; triptans are commonly used in the treatment; rizatriptan benzoate is a member of the triptan class, it’s available as a tablet dosage form. Unfortunately, it undergoes fi rst-pass eff ect after oral intake. The intranasal route of administration represents a solve to such a problem. Because it has a limited permeability, an eff ort has been made to circumvent this hurdle. Nanotechnology’s innovation has off ered a useful answer to several issues in the pharmaceutical fi eld in which it could improve drug permeability. The aim of the present work involved loading rizatriptan benzoate on a nanostructured lipid carrier as an attempt to resolve adversity affi liated with the intended drug. The high-speed homogenization technique prepares six formulas. The formulations’ particle size, polydispersity index, zeta potential, entrapment effi ciency, loading capacity, and in-vitro drug release were studied. Diff erential scanning calorimetry (DSC), Fourier transforms infrared spectroscopy (FTIR), and powder X-ray diff raction (PXRD) was investigated to exclude drug excipient incompatibility and to evaluate the crystallinity state of rizatriptan benzoate before and after formulation. Successful formulations were obtained with an acceptable nanostructured parameter In-vitro drug release profi le illustrates a biphasic pattern in which an immediate followed by a persistent phase over a 6 hours. release period, with an estimated percent of the medication being released with an anomalous release mechanism. The compatibility and crystallinity investigation revealed that rizatriptan benzoate was compatible with the other excipients used in the research, and the drug molecule was found to be in an amorphous state within the lipid matrix. In conclusion, nanostructured lipid carriers might be a potential delivery approach for improving intranasal administration of rizatriptan benzoate.

show abstract

Section: Effect Of Zeta Potential (Zp)supporting

confidence: 74%

Preparation and Evaluation of Rizatriptan Benzoate Loaded Nanostructured Lipid Carrier Using Diff erent Surfactant/Co-Surfactant Systems

Rajab¹,

Jawad²

2023

IJDDT

View full text Add to dashboard Cite

show abstract

“…Above those concentrations, the assemblies formed O/W emulsion or micelle depending on the CaTG concentration. In the LNP studies, the role of the T80 is originally for surface-active agents; , consequently, to stabilize the particle, the concentration should be adequate to cover the particle surface. Regarding this property, the samples with high CP (saturated lipid), CP/CaTG/T80 = 62.5/10/27.5 (no.…”

Section: Resultsmentioning

confidence: 99%

“…Interestingly, NLCs have a converse behavior; the liquid state-assembly such as O/W emulsion (disordered phase) tended to form a smaller particle size, and those with solid state-assembly (ordered phase) tended to form a bigger particle size. This anomaly might correspond to the presence of the surfactant in the NLC constituent as it played a vital role in controlling the particle size. , …”

Section: Resultsmentioning

confidence: 99%

“…Cetyl palmitate (CP) (solid lipid) and caprylic triglyceride (CaTG) (liquid lipid) were herein employed as core lipid components. The combination of the two lipids has been reported to produce an excellent physical property of NLCs. , Polysorbate 80 (Tween 80 (T80)) was selected as a particle stabilizer (surfactant) to reduce the particle size and increase the stability. ,,, The lipid mixtures used in this study are presented in Table . Based on the fluorescent probe technique, the membrane fluidity and polarity of ternary mixture systems of CP/CaTG/T80 were analyzed.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Systematic Characterization of Nanostructured Lipid Carriers from Cetyl Palmitate/Caprylic Triglyceride/Tween 80 Mixtures in an Aqueous Environment

et al. 2021

View full text Add to dashboard Cite

Nanostructured lipid carriers (NLCs) are gaining attention as the new generation of lipid vehicles. These carriers consist of saturated lipids with small drops of liquid oil dispersed into the inner lipid matrix and are stabilized by a surfactant. Conventionally, NLC-based drug delivery systems have been widely studied, and many researchers are looking into the composition of NLC properties to improve the performance of NLCs. The membrane fluidity and polarity of self-assembling lipids are also essential properties that must be affected by membrane compositions; however, such fundamental characteristics have not been studied yet. In this study, NLCs were prepared from cetyl palmitate (CP), caprylic triglyceride (CaTG), and Tween 80 (T80). Structural properties, such as particle size and ζ-potential of the CP/CaTG/T80 ternary mixtures, were investigated. Then, the systematic characterization of self-assembly properties using fluorescence-based analysis was applied for the first time to the NLC system. As a final step, the ternary diagram was developed based on the self-assembly properties to summarize the possible structures formed at different compositions. The results showed four states: micelle-like, oil-in-water (O/W) emulsion-like, solid lipid nanoparticle-like, and intermediate (solid−liquid coexistence). For the purpose of making the lipid matrix more liquified, the heterogeneous state and the disordered state of the O/W emulsionlike structure might fulfill the criteria of NLCs. Finally, the ternary diagram provides new information about the assembly state of NLC constituents that could become an important reference for developing high-performance NLCs.

show abstract

“…Alam et al described a NLC that released 84% simvastatin in 24 h, and the best fit model was Korsmeyer-Peppas (R 2 = 0.985 and n = 0.49) [73]. In a recent study, Eh Suk et al evaluated several NLC formulations, concluding that even though Korsmeyer-Peppars is a model for polymeric matrices, it well represents release from NLC [74]. Table 3.…”

Section: Release Studiesmentioning

confidence: 99%

Development of a Nanostructured Lipid Carrier (NLC) by a Low-Energy Method, Comparison of Release Kinetics and Molecular Dynamics Simulation

et al. 2021

View full text Add to dashboard Cite

Lipid nanocarriers have a great potential for improving the physicochemical characteristics and behavior of poorly water-soluble drugs, such as aqueous dispersibility and oral bioavailability. This investigation presents a novel nanostructured lipid carrier (NLC) based on a mixture of solid lipid glycerides, fatty acid esters of PEG 1500 (Gelucire® 44/14), and an oil mix composed of capric and caprylic triglycerides (Miglyol® 812). These NLCs were developed by a simple low-energy method based on melt emulsification to yield highly encapsulating and narrowly distributed nanoparticles (~100 nm, PdI = 0.1, and zeta potential = ~−10 mV). Rhodamine 123 was selected as a poorly water-soluble drug model and owing to its spectroscopic properties. The novel NLCs were characterized by dynamic light scattering (DLS), zeta potential, nanoparticle tracking analysis (NTA), transmission electron microscopy (TEM), differential scanning calorimetry (DSC), and colloidal stability. The drug release was determined through a dialysis bag and vertical Franzs’ cells to provide insights about the methods’ suitability, revealing similar performance regardless of their different fluid dynamics. Rhodamine 123 followed a characteristic biphasic release profile owing to the swelling of the hydrophilic polymer coating and diffusion process from the lipid core as revealed by the Korsmeyers–Peppas kinetic modeling. Moreover, to elucidate the formation and incorporation of Rhodamine 123 into the NLC core, several molecular dynamics simulations were conducted. The temperature was shown to be an important condition to improve the formation of the nanoparticles. In addition, the liquid lipid incorporation to the formulation forms nanoparticles with imperfect centers, in contrast to nanoparticles without it. Moreover, Miglyol® 812 improves hydrophobic molecule solubility. These results suggest the potential of novel NLC as a drug delivery system for poorly water-soluble drugs.

show abstract

Development of nanostructured lipid carrier (NLC) assisted with polysorbate nonionic surfactants as a carrier for l-ascorbic acid and Gold Tri.E 30

Cited by 21 publications

References 31 publications

Preparation and Evaluation of Rizatriptan Benzoate Loaded Nanostructured Lipid Carrier Using Diff erent Surfactant/Co-Surfactant Systems

Preparation and Evaluation of Rizatriptan Benzoate Loaded Nanostructured Lipid Carrier Using Diff erent Surfactant/Co-Surfactant Systems

Systematic Characterization of Nanostructured Lipid Carriers from Cetyl Palmitate/Caprylic Triglyceride/Tween 80 Mixtures in an Aqueous Environment

Development of a Nanostructured Lipid Carrier (NLC) by a Low-Energy Method, Comparison of Release Kinetics and Molecular Dynamics Simulation

Contact Info

Product

Resources

About