Development of nanoparticles from natural lipids for topical delivery of thymol: Investigation of its anti-inflammatory properties

Pivetta, Thais P.; Simões, Sandra; Araujo, Margarete Moreno de; Carvalho, Tânia; Arruda, Caroline; Marcato, Priscyla D.

doi:10.1016/j.colsurfb.2018.01.053

Cited by 143 publications

(105 citation statements)

References 44 publications

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“…These isomers also present high antimicrobial potential. Thymol may inhibit the growth of Staphylococcus aureus, Escherichia coli , S. aureus, E. coli and Pseudomonas aeruginosa , S. aureus, Enterococcus faecalis, E. coli and Candida albicans . Supporting this idea, Altiok et al .…”

Section: Discussionmentioning

confidence: 91%

“…The preclinical study recently published by Pivetta et al . developed a gel of carbopol containing nanoencapsulated thymol (50% w/w).…”

Section: Resultsmentioning

confidence: 99%

“…Only one study was funded by a company with a statement of potential benefit from the results of this research. In addition, 03 articles did not receive financial support and 04 studies did not present this information …”

Section: Resultsmentioning

confidence: 99%

“…The preclinical study recently published by Pivetta et al [24] developed a gel of carbopol containing nanoencapsulated thymol (50% w/w). They tested cytotoxicity in human keratinocytes, noting that nanoencapsulated thymol maintained cell viability above 80% and could then be considered as non-cytotoxic.…”

Section: Thymolmentioning

confidence: 99%

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Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

Costa

Durço

Rabelo

et al. 2018

Journal of Pharmacy and Pharmacology

104

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Objectives The treatment of wounds accounts for a considerable fraction of health expenses as well as serious socioeconomic problems. The use of natural substances stands out as a source of new therapeutic discoveries for the wound healing. Thus, this review compiled scientific findings on the applicability of carvacrol and thymol, or essential oils containing at least one of these compounds, for the treatment of wounds. Methods This review was performed at PubMed, SCOPUS, Web of Science databases using keywords as wound healing, thymol/carvacrol and essential oils. Thirteen studies were selected for discussion. Key findings Thymol/carvacrol was able to act in the three phases of wound healing. In the first phase, they showed modulatory effect of the inflammatory cytokines, oxidative stress and antimicrobial power. In the second phase, they promoted re‐epithelialization, angiogenesis and development of granulation tissue. Finally, in the third phase, they improve the collagen deposition and modulated the growth of fibroblasts and keratinocytes. Conclusions These compounds present a high potential for the development of new therapeutic for wound repair. However, dose, efficacy and safety of these compounds for the treatment of wounds, as well as the mechanisms by which those effects can be observed, are challenges for future studies.

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Section: Discussionmentioning

confidence: 91%

“…The preclinical study recently published by Pivetta et al . developed a gel of carbopol containing nanoencapsulated thymol (50% w/w).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Thymolmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

Costa

Durço

Rabelo

et al. 2018

Journal of Pharmacy and Pharmacology

104

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“…24 Due to the superiority of super-specific targeting of tumor cells and immune cells, cellular imaging capability and low cytotoxicity, the nanocarrier-based therapeutic delivery system is widely used for various diseases. 27,28 Liposome is one of the most reported nanocarriers, which is a naturally occurring phospholipid-based amphipathic nanocarrier. 27,28 Liposome is one of the most reported nanocarriers, which is a naturally occurring phospholipid-based amphipathic nanocarrier.…”

Section: Discussionmentioning

confidence: 99%

Topical administration of nanocarrier miRNA‐210 antisense ameliorates imiquimod‐induced psoriasis‐like dermatitis in mice

Feng

Zhang

et al. 2019

The Journal of Dermatology

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Psoriasis is a chronic, recurrent inflammatory autoimmune skin disease. Although its etiology and pathogenesis are complex and multifarious, it has been proved to be closely related to dysregulation of immune cell function as well as keratinocyte proliferation/differentiation. Our previous study demonstrated that miRNA-210 (miR-210) plays an important role in the formation of skin lesions and immune imbalance in psoriasis. Here, we developed a biomimetic reconstituted high-density lipoprotein (rHDL) nanocarrier gel containing miR-210 antisense (NG-anti-miR-210) to investigate its effect on imiquimod (IMQ)-induced psoriasis-like dermatitis in mice. We found that topical treatment with NG-anti-miR-210 significantly decreased the expression of miR-210 in both the skin lesions and splenic CD4 + T cells from IMQ-induced psoriasis-like mouse models and ameliorated the dermatitis in terms of the erythema, scales, acanthosis and dermal inflammatory cell infiltration in IMQ-induced mice. In addition, the proportion of T-helper (Th)1 and Th17 cells in dermal and splenic cells of IMQ-treated mice were decreased by application of NG-anti-miR-210, accompanied by decreased interleukin-17A and c-interferon mRNA levels. Therefore, our data demonstrate that topical inhibition of miR-210 delivered by rHDL nanocarrier effectively alleviates the psoriasis-like inflammation in mice and provides a potentially effective topical drug for psoriasis.

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Thymol and Carvacrol: Phenolic Monoterpenes Extracted from the Essential Oil of Thymus vulgaris as Natural Antimicrobial Guests of Nanoporous Crystalline Syndiotactic Polystyrene Fibers

Cozzolino

Botta

Daniel

et al. 2023

Macromolecular Symposia

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Thymol and carvacrol, relevant natural antimicrobial molecules, induce co‐crystallization and, in absence of any mechanical stretching, also high degrees of axial orientation on s‐PS amorphous fibers. The release of thymol and carvacrol from s‐PS co‐crystalline fibers has been analyzed to realize long‐term antimicrobial fabrics. Partition between isolated guest molecules, present in co‐crystalline phase or simply dissolved in the amorphous phase, has been investigated by FTIR and thermogravimetric measurements. These analyses have been confirmed by polarized FTIR spectra of axially oriented s‐PS films.

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Development of nanoparticles from natural lipids for topical delivery of thymol: Investigation of its anti-inflammatory properties

Cited by 143 publications

References 44 publications

Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

Topical administration of nanocarrier miRNA‐210 antisense ameliorates imiquimod‐induced psoriasis‐like dermatitis in mice

Thymol and Carvacrol: Phenolic Monoterpenes Extracted from the Essential Oil of Thymus vulgaris as Natural Antimicrobial Guests of Nanoporous Crystalline Syndiotactic Polystyrene Fibers

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