Development of Nanoparticles for Antimicrobial Drug Delivery

Abstract

This review focuses on the development of nanoparticle systems for antimicrobial drug delivery. Numerous antimicrobial drugs have been prescribed to kill or inhibit the growth of microbes such as bacteria, fungi and viruses. Even though the therapeutic efficacy of these drugs has been well established, inefficient delivery could result in inadequate therapeutic index and local and systemic side effects including cutaneous irritation, peeling, scaling and gut flora reduction. Nanostructured biomaterials, nanoparticles in particular, have unique physicochemical properties such as ultra small and controllable size, large surface area to mass ratio, high reactivity, and functionalizable structure. These properties can be applied to facilitate the administration of antimicrobial drugs, thereby overcoming some of the limitations in traditional antimicrobial therapeutics. In recent years, encapsulation of antimicrobial drugs in nanoparticle systems has emerged as an innovative and promising alternative that enhances therapeutic effectiveness and minimizes undesirable side effects of the drugs. Here the current progress and challenges in synthesizing nanoparticle platforms for delivering various antimicrobial drugs are reviewed. We also call attention to the need to unite the shared interest between nanoengineers and microbiologists in developing nanotechnology for the treatment of microbial diseases.

An investigation of the interactions between an E. coli bacterial quorum sensing biosensor and chitosan-based nanocapsules

“…Other nanomaterials bearing a positively-charged surface, such as diamond nanoparticles, bind closely to the surface of bacteria [7]. On the other hand, conjugation of targeting ligands such as aptamers [8], peptides [9], or DNA [10], also confers nanomaterials with targeting capacity toward microorganisms [11][12][13]. Different types of microscopy (e.g., TEM, AFM, SEM) and molecular biology techniques offer powerful approaches to probe bacteria-nanomaterials interactions [14][15][16][17][18][19].…”

Recent advances in materials for extended-release antibiotic delivery system

“…One of the areas that have benefited from the advance is microbiology. A valuable review regarding the development of nanoparticles for antimicrobial drug delivery is by Zhang et al 67 Herein, we focus on the sustained-release role of nanoparticles for antibiotic delivery and materials used for the delivery. Owing to their ultrasmall size, nanoparticle formulations have many advantages over traditional dosage forms.…”

“…68,69 Moreover, antibiotic-loaded nanoparticles can enter host cells through endocytosis and then release drug payloads to treat microbe-induced intracellular infections. 67 As the review of Zhang et al 67 has covered a wide field of liposomes, solid lipid nanoparticles and dendrimers for antimicrobial drug delivery, here we only summarize polymers and inorganic materials used in nanoparticles.…”

Uso de antimicrobiano nanoparticulado para o tratamento da mastite subclínica de ovelhas de corte no período seco

“…As propriedades da partícula tais como o tamanho, potencial zeta e o perfil de liberação do fármaco podem ser ajustadas precisamente escolhendo diferentes comprimentos de polímeros, surfactantes e solventes orgâ-nicos durante a síntese. A superfície de nanopartículas poliméricas geralmente contém grupos funcionais que podem ser modificados quimicamente (Zhang et al 2010).…”