Development of Nanoparticle-Enabled Protein Biomarker Discovery: Implementation for Saliva-Based Traumatic Brain Injury Detection

Caswell, Shane V.; Cortés, Nelson; Mitchell, Kelsey; Liotta, Lance A.; Petricoin, Emanuel F.

doi:10.1007/978-3-662-45399-5_6

Cited by 4 publications

(2 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Saliva osmolality can provide hydration status in exercise research [196], whilst S100 calcium binding protein B (S100B) has shown promise as a non-invasive biomarker of brain injury in various sportsmen during competition [197]. More recently, nanoparticle-enabled protein biomarkers (proteomics) have been proposed as sensitive indicators of brain injury/concussion, with further developments required [198].…”

Section: Other Biomarkersmentioning

confidence: 99%

Realising the Potential of Urine and Saliva as Diagnostic Tools in Sport and Exercise Medicine

Lindsay

Costello

2016

Sports Med

View full text Add to dashboard Cite

Accurate monitoring of homeostatic perturbations following various psychophysiological stressors is essential in sports and exercise medicine. Various biomarkers are routinely used as monitoring tools in both clinical and elite sport settings. Blood collection and muscle biopsies, both invasive in nature, are considered the gold standard for the analysis of these biomarkers in exercise science. Exploring non-invasive methods of collecting and analysing biomarkers that are capable of providing accurate information regarding exercise-induced physiological and psychological stress is of obvious practical importance. This review describes the potential benefits, and the limitations, of using saliva and urine to ascertain biomarkers capable of identifying important stressors that are routinely encountered before, during, or after intense or unaccustomed exercise, competition, over-training, and inappropriate recovery. In particular, we focus on urinary and saliva biomarkers that have previously been used to monitor muscle damage, inflammation, cardiovascular stress, oxidative stress, hydration status, and brain distress. Evidence is provided from a range of empirical studies suggesting that urine and saliva are both capable of identifying various stressors. Although additional research regarding the efficacy of using urine and/or saliva to indicate the severity of exercise-induced psychophysiological stress is required, it is likely that these non-invasive biomarkers will represent "the future" in sports and exercise medicine.

show abstract

Section: Other Biomarkersmentioning

confidence: 99%

Realising the Potential of Urine and Saliva as Diagnostic Tools in Sport and Exercise Medicine

Lindsay

Costello

2016

Sports Med

View full text Add to dashboard Cite

show abstract

“…The aim of this review is to highlight the growing importance of human saliva as a diagnostic medium, the availability of new and standardized tools for saliva specimen, and general protocols for saliva sampling, storage, and processing, which have changed significantly since the last reviews on this subject. For a more detailed overview of salivary diagnostics, potential applications, and tools, the reader is referred to several excellent reviews on this subject [ 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Human Saliva Collection Devices for Proteomics: An Update

Khurshid

Zohaib

Najeeb

et al. 2016

IJMS

128

106

View full text Add to dashboard Cite

There has been a rapid growth in the interest and adaptation of saliva as a diagnostic specimen over the last decade, and in the last few years in particular, there have been major developments involving the application of saliva as a clinically relevant specimen. Saliva provides a “window” into the oral and systemic health of an individual, and like other bodily fluids, saliva can be analyzed and studied to diagnose diseases. With the advent of new, more sensitive technologies to detect smaller concentrations of analytes in saliva relative to blood levels, there have been a number of critical developments in the field that we will describe. In particular, recent advances in standardized saliva collection devices that were not available three to four years ago, have made it easy for safe, simple, and non-invasive collection of samples to be carried out from patients. With the availability of these new technologies, we believe that in the next decade salivary proteomics will make it possible to predict and diagnose oral as well as systemic diseases, cancer, and infectious diseases, among others. The aim of this article is to review recent developments and advances in the area of saliva specimen collection devices and applications that will advance the field of proteomics.

show abstract