Development of nanoemulsions containing Lavandula dentata or Myristica fragrans essential oils: Influence of temperature and storage period on physical-chemical properties and chemical stability

Cossetin, Luciana F.; Garlet, Quelen Iane; Velho, Maiara Callegaro; Gündel, Samanta da Silva; Ourique, Aline Ferreira; Heinzmann, Berta Maria; Monteiro, Sílvia González

doi:10.1016/j.indcrop.2020.113115

Cited by 21 publications

(8 citation statements)

References 48 publications

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“…CSO can be investigated as a possible candidate for skin diseases based on its profile of high-value chemicals and nutrients. Recently, the NE formulations of various essential oils, such as clove oil, niaouli essential oil, cinnamon oil, lavender oil, and nutmeg oil have been investigated in literature [11,12,[14][15][16][17]. However, the NE formulations of CSO or its biomarker molecules have not been explored in the literature, to the best of the author's knowledge.…”

Section: Introductionmentioning

confidence: 99%

Product Development Studies of Cranberry Seed Oil Nanoemulsion

et al. 2022

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Cranberry seed oil (CSO) can be used in various skin diseases, perhaps due to the presence of ω-3, ω-6, and ω-9 fatty acids. In addition, tocotrienols (vitamin E) has demonstrated powerful antioxidant activity. The combined application of CSO nanoemulsions open a promising avenue for skin conditions. The goal of this work was to create a nanoemulsion (NE) containing CSO and test its stability and in vitro release. To make NE formulations (CNE1-CNE6), the aqueous titration method was used. Following the creation of NE formulations, we selected the CNE4 formulation, which had a mean droplet size of around 110 nm, a narrow size distribution (PDI < 0.2), a steady zeta potential (−34.21 mV), and a high percentage transmittance (>99%). Furthermore, electron microscopy imaging revealed nanosized spherical droplets without any aggregation in the CNE4 formulation, which showed high entrapment efficiency (>80%). Densitometry analysis confirmed linoleic acid (RF 0.62) as a major component of CSO using toluene–acetone–glacial acetic acid (90:9:1 v/v/v) as a mobile phase. Nanogel had a three-fold greater cumulative drug permeation through the skin than neat CSO. This study shows that a unique CSO delivery technique can be used to treat skin diseases.

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Section: Introductionmentioning

confidence: 99%

Product Development Studies of Cranberry Seed Oil Nanoemulsion

et al. 2022

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“…Particularly, high-energy (pressure) homogenization is the technique more effective and more used in practice, which employs mechanical tools to induce disruptive forces to break up and blend the oily phase and oil droplets. In fact, recent studies continue to demonstrate the effectiveness of this technique for (nano)emulsion fabrication [13][14][15][16][17][18][19][20][21][22], even when using essential oils [23][24][25][26]. On the other hand, the aqueous phase, which typically consists of water, can contain other polar components (e.g., co-solvents, minerals, acids, and bases) where the type and concentration of these components determines the polarity, interfacial tension, rheology, pH, and ionic strength, to name just a few prominent examples that influence the formation, stability, and physicochemical properties of the nanoemulsion [10].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Physicochemical Properties of Nanoemulsions Fabricated with Natural and Synthetic Surfactants

et al. 2021

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This work aims to evaluate the effect of two natural (whey protein isolate, WPI, and soy lecithin) and a synthetic (Tween 20) emulsifier on physicochemical properties and physical stability of food grade nanoemulsions. Emulsions stabilized by these three surfactants and different sunflower oil contents (30% and 50% w/w), as the dispersed phase, were fabricated at two levels of homogenization pressure (500 and 1000 bar). Nanoemulsions were characterized for droplet size distribution, Zeta-potential, rheological properties, and physical stability. Dynamic light scattering showed that droplet size distributions and D50 values were strongly affected by the surfactant used and the oil content. WPI gave similar droplet diameters to Tween 20 and soy lecithin gave the larger diameters. The rheology of emulsions presented a Newtonian behavior, except for WPI-stabilized emulsions at 50% of oil, presenting a shear-thinning behavior. The physical stability of the emulsions depended on the surfactant used, with increasing order of stability as follows: soy lecithin < Tween 20 < WPI. From our results, we conclude that WPI is an effective natural replacement of synthetic surfactant (Tween 20) for the fabrication of food-grade nanoemulsions.

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“…Kaur et al [ 6 ] also observed a zeta potential value lower than 30 mV, but the nanoemulsion produced had a higher stability percentage compared to the individual oil tested. Cossetin et al [ 28 ] also encountered the same situation when their nanoemulsion zeta potential value was only 11 mV, but the formulation was remarkably stable for more than three months.…”

Section: Resultsmentioning

confidence: 90%

Preparation, Characterization and Biological Activities of an Oil-in-Water Nanoemulsion from Fish By-Products and Lemon Oil by Ultrasonication Method

et al. 2022

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Fish by-product oil and lemon oil have potential applications as active ingredients in many industries, including cosmetics, pharmaceuticals and food. However, the physicochemical properties, especially the poor stability, compromised the usage. Generally, nanoemulsions were used as an approach to stabilize the oils. This study employed an ultrasonication method to form oil-in-water nanoemulsion of lemon and fish by-product oils (NE-FLO). The formulation is produced at a fixed amount of 2 wt% fish by-product oil, 8 wt% lemon oil, 10 wt% surfactant, 27.7 wt% co-surfactants and 42 min of ultrasonication time. The size, polydispersity index (PDI) and zeta potential obtained were 44.40 nm, 0.077, and −5.02 mV, respectively. The biological properties, including antioxidant, antibacterial, cell cytotoxicity, and anti-inflammatory, showed outstanding performance. The antioxidant activity is comparable without any significant difference with ascorbic acid as standard and is superior to pure lemon oil. NE-FLO successfully inhibits seven Gram-positive and seven Gram-negative bacterial strains. NE-FLO’s anti-inflammatory activity is 99.72%, comparable to nordihydroguaiaretic acid (NDGA) as the standard. At a high concentration of 10,000 µg. mL−1, NE-FLO is non-toxic to normal skin cells. These findings demonstrate that the NE-FLO produced in this study has significant potential for usage in various industries.

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Development of nanoemulsions containing Lavandula dentata or Myristica fragrans essential oils: Influence of temperature and storage period on physical-chemical properties and chemical stability

Cited by 21 publications

References 48 publications

Product Development Studies of Cranberry Seed Oil Nanoemulsion

Product Development Studies of Cranberry Seed Oil Nanoemulsion

Comparative Study of Physicochemical Properties of Nanoemulsions Fabricated with Natural and Synthetic Surfactants

Preparation, Characterization and Biological Activities of an Oil-in-Water Nanoemulsion from Fish By-Products and Lemon Oil by Ultrasonication Method

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