Development of myelination in the human fetal and infant cerebrum: A myelin basic protein immunohistochemical study

Hasegawa, Mitsugu; Houdou, Sadataka; Mito, Takashi; Takashima, Sachio; Asanuma, Katsumi; Ohno, Tsutomu

doi:10.1016/s0387-7604(12)80271-3

Cited by 123 publications

(86 citation statements)

References 8 publications

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“…Relationships described in adults have not specifically been shown with language, but with verbal recall (Catani et al, 2007), and asymmetry of tractographyderived streamlines in the arcuate showed a marked ceiling effect with a significant proportion of children showing 100% leftward asymmetry (i.e., no right arcuate fasciculus; Lebel and Beaulieu, 2009). Using fractional anisotropy, a measure of white matter fiber architecture, asymmetries in the arcuate fasciculus have been also shown in infants (Dubois et al, 2009). Though not discussed in detail, leftward asymmetries in areas relevant here such as the anterior thalamus, mesial frontal cortex and rightward asymmetries in the anterior insula were also detected.…”

Section: Discussionmentioning

confidence: 89%

“…It is possible that leftward asymmetry of mesial frontal cortex is anatomically related to the thalamic and caudate myelin asymmetry as it overlaps spatially with thalamofrontal projections (Fair et al, 2010;O'Muircheartaigh et al, 2011). However, this is unlikely given their differing relationship and direction with language abilities (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Although investigating older children and gray matter, these results imply differential recruitment of anatomical pathways to support cognitive ability during development. Investigations of younger groups have demonstrated extensive postnatal changes in cortical gray matter (Dubois et al, 2010) with early indications of subcortical structure in infancy positively predicting later language skills (Deniz Can et al, 2013). The data presented here are cross sectional, longitudinal analysis will allow us to confirm these findings; however, the changing interaction between ability and myelin may be mediated by progressive functional specialization in these connected cortical regions, which itself is partly mediated by environmental influences (Johnson, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…Deviations from typical patterns of cortical and functional asymmetry have been related to autism (Eyler et al, 2012), developmental language disorders (Herbert et al, 2005), and schizophrenia (Kawasaki et al, 2008). These neurodevelopmental disorders have been characterized within the framework of white matter disconnectivity (Catani and ffytche, 2005;Fields, 2008).…”

Section: Discussionmentioning

confidence: 99%

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Interactions between White Matter Asymmetry and Language during Neurodevelopment

et al. 2013

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The human brain is asymmetric in gross structure as well as functional organization. However, the developmental basis and trajectory of this asymmetry is unclear, and its relationship(s) to functional and cognitive development, especially language, remain to be fully elucidated. During infancy and early childhood, in concert with cortical gray matter growth, underlying axonal bundles become progressively myelinated. This myelination is critical for efficient and coherent interneuronal communication and, as revealed in animal studies, the degree of myelination changes in response to environment and neuronal activity. Using a novel quantitative magnetic resonance imaging method to investigate myelin content in vivo in human infants and young children, we investigated gross asymmetry of myelin in a large cohort of 108 typically developing children between 1 and 6 years of age, hypothesizing that asymmetry would predict language abilities in this cohort. While asymmetry of myelin content was evident in multiple cortical and subcortical regions, language ability was predicted only by leftward asymmetry of caudate and frontal cortex myelin content and rightward asymmetry in the extreme capsule. Importantly, the influence of this asymmetry was found to change with age, suggesting an age-specific influence of structure and myelin on language function. The relationship between language ability and asymmetry of myelin stabilized at ϳ4 years, indicating anatomical evidence for a critical time during development before which environmental influence on cognition may be greatest.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Interactions between White Matter Asymmetry and Language during Neurodevelopment

et al. 2013

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“…120 It is well known that regions of the brain undergoing myelination show greater metabolic activities than those not yet myelinated. [118][119][120] MRI studies of newborns who suffer significant hypoperfusion injuries consistently show a close correlation between the normal patterns of agerelated myelination and the sites of brain injury. 101,[120][121][122] A second theory suggests that the pattern of brain injury in hypoxic-ischaemic encephalopathy is related to the distribution of N-methyl-D-asparate (NMDA) receptors.…”

mentioning

confidence: 80%

Visual function in the brain-damaged child

Hoyt

2003

Eye

150

164

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Human fetal hippocampal development: I. Cytoarchitecture, myeloarchitecture, and neuronal morphologic features

Arnold¹,

Trojanowski²

1996

J. Comp. Neurol.

190

101

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To characterize better the process of anatomic development of the human hippocampus, we studied the cytoarchitecture, myeloarchitecture, and neuronal morphology in human fetal and postnatal hippocampi. Twenty cases were studied in which the ages ranged from 9 weeks gestation through 62 years. Fixed, paraffin-embedded, hippocampal sections were stained with cresyl violet for Nissl substance and immunolabeled for myelin basic protein. The hippocampal region at 9 weeks contains 4 layers: a ventricular zone, an intermediate zone, a homogeneous-appearing hippocampal plate comprised of bipolar-shaped neurons, and a wide marginal zone. At 15-19 weeks, individual subfields can be distinguished. A distal-to-proximal gradient of cytoarchitectural and neuronal morphologic maturity is seen, with the subiculum appearing more developed than the ammonic subfields and the dentate gyrus appearing least mature. Within each subfield, an "inside-out" gradient of maturity is also evident. By 32-34 weeks gestational age, neurons in CA2 and CA3 have undergone rapid enlargement and morphologic maturation, surpassing CA1, which still contains some immature neurons. The dentate gyrus is the latest area to develop, only assuming a mature cytoarchitecture after 34 weeks. The essential cytoarchitectural appearance of the hippocampal subfields is stable after birth, although there is progressive neuronal enlargement and a decrease in neuronal density throughout childhood into adulthood. Myelination is first evident near term, with strong myelin basic protein immunoreactivity present in the angular bundle, alveus, and fimbria and relatively scant immunoreactivity in the nascent perforant pathway. Myelination in the hippocampus increases in childhood until adolescence, after which the pattern remains unchanged. These studies delineate normal neuroanatomic development and can be used to understand better the mechanisms underlying human neurodevelopmental and neurodegenerative disorders of the hippocampal formation.

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Development of myelination in the human fetal and infant cerebrum: A myelin basic protein immunohistochemical study

Cited by 123 publications

References 8 publications

Interactions between White Matter Asymmetry and Language during Neurodevelopment

Interactions between White Matter Asymmetry and Language during Neurodevelopment

Visual function in the brain-damaged child

Human fetal hippocampal development: I. Cytoarchitecture, myeloarchitecture, and neuronal morphologic features

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